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Prediagnostic calcium intake and lung cancer survival: A pooled analysis of 12 cohort studies
(Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-03-06)
<p><i>Background</i>: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival.</p>
<p><i>Methods</i>: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort ...
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
(Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-04-10)
Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust ...
Testing alternative regression models to predict utilities: mapping the QLQ-C30 onto the EQ-5D-5L and the SF-6D
(Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2018-09-01)
<p><i>Purpose</i>: The purpose of the study was to compare alternative statistical techniques to find the best approach for converting QLQ-C30 scores onto EQ-5D-5L and SF-6D utilities, and to estimate the mapping algorithms that best predict these health state utilities.</p>
<p><i>Methods</i>: 772 cancer patients described their health along the cancer-specific instrument (QLQ-C30) and two generic ...
Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better
(Journal article; Preprint; Tidsskriftartikkel; Peer reviewed; Manuskript, 2015-06-25)
To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ...
Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study
(Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-07-21)
<p><i>Purpose</i>: There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years.</p>
<p><i>Methods</i>: This study includes 373,293 men and women, 25–70 years old, recruited between 1992 and 2000 from 10 European countries in the European ...
Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed; Preprint; Manuskript, 2017-07-01)
Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective ...
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies
(Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-05-26)
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 ...
Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species
(Journal article; Tidsskriftartikkel; Manuskript; Peer reviewed; Preprint, 2017-09-18)
Mold particles from <i>Aspergillus fumigatus, Penicillium chrysogenum, Aspergillus versicolor</i>, and <i>Stachybotrys chartarum</i> have been linked to respiratory‐related diseases. We characterized X‐ray‐inactivated spores and hyphae fragments from these species by number of particles, morphology, and mycotoxin, β‐glucan and protease content/activity. The pro‐inflammatory properties of mold particles ...