Search
Now showing items 1-10 of 94
Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
<p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p>
...
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-12)
<b>Background:</b> <br>
Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic
control in patients with diabetes. Previous genome-wide association studies (GWAS)
have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable
by their likely biological action as erythrocytic (also associated with erythrocyte traits)
or ...
Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
<p><i>Background</i>: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated.</p>
<p><i>Methods and Results</i>: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF ...
Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979–2012
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-08)
The data presented in this article relate to the research article entitled “Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979–2012” (Albrektsen et al., 2017) [1]. Data quantify the gender differences in the risk of myocardial infarction (MI) in terms of incidence rate ratios (IRR), in subgroups defined by serum lipids, ...
Health in overweight children: 2-year follow-up of Finnmark Activity School-a randomised trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-20)
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21–6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we ...
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ...
Cohort profile: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
The Tromsø Study was initiated in 1974 in an attempt to help combat the high mortality of cardiovascular diseases in Norway, that was particularly pronounced among middle-aged men. In the mid-1970s, Norwegian men had a 20% risk of dying of myocardial infarction (MI) before the age of 75 years. The situation in Northern Norway was even worse.1 The primary aim of the Tromsø Study was to determine ...
A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and ...