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Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)
<i>Background</i>: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated.<p>
<p><i>Objective</i>: To characterize breast cancer risk in relation to recent childbirth.<p>
<p>Design</i> : Pooled ...
Association of menopausal characteristics and risk of coronary heart disease: A pan-European case-cohort analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
<i>Background</i>
- Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these ...
Development and validation of circulating CA125 prediction models in postmenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)
<i>Background</i>
- Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p>
<i>Methods</i>
- We developed and validated ...
Prospective analysis of circulating metabolites and breast cancer in EPIC
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
<i>Background</i> - Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk.<p>
<p><i>Methods</i> - A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which ...
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-02)
<i>Background</i>
- Even though in situ breast cancer (BCIS) accounts for a large proportion of the breast cancers diagnosed, few studies have investigated potential risk factors for BCIS. Their results suggest that some established risk factors for invasive breast cancer have a similar impact on BCIS risk, but large population-based studies on lifestyle factors and BCIS risk are lacking. Thus, ...
One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case–control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre‐diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell ...
Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the ...
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-25)
Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the
risk of colorectal cancer (CRC) development. We examined the association between CRC risk and
genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway
genes. <i>Illumina Goldengate</i> assays were designed and resulted in the genotyping of 1040 variants
in 154 genes ...
Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-20)
Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, ...
Association of circulating Vitamin D with colorectal cancer depends on Vitamin D-binding protein isoforms: A pooled, nested, case-control study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-15)
<i>Background</i> - Higher circulating 25-hydroxyvitamin-D [25(OH)D] concentrations are consistently inversely associated with colorectal cancer (CRC) risk in observational studies. However, it is unknown whether this association depends on the functional GC-rs4588*A (Thr436Lys) variant encoding the vitamin D–binding protein-2 (DBP2) isoform, which may affect vitamin D status and bioavailability.< ...