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Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
<p><i>Background</i>: Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated.</p>
<p><i>Methods and Results</i>: Data from the fourth survey (1994–1995) of the Tromsø Study (Norway) were used to investigate the association of single‐measurement BMI on future AF ...
Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction (MI), type 2 diabetes (T2DM), cancer and all-cause mortality. Recently several single nucleotide polymorphisms (SNPs) associated with serum 25-hydroxyvitamin D (25(OH)D) level have been identified. If these relations are causal one would expect a similar association between these ...
Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-31)
Aims:
To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a
general population.
<br>Methods and results:
We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. End-
points were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We strati
fi
ed the analyses ...
Association of occasional smoking with total mortality in the population-based Tromsø study, 2001-2015
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
Objectives: <br> There is a shift in the smoking population
from daily smokers to light or occasional smokers. The
knowledge about possible adverse health effects of this
new smoking pattern is limited. We investigated smoking
habits with focus on occasional smoking in relation to
total mortality in a follow-up study of a Norwegian general
population. <br>
Setting: <br> A population study ...
Pain tolerance in persons with recognized and unrecognized myocardial infarction: a population-based, cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-21)
<b>Background</b> Unrecognized myocardial infarction (MI) is a prevalent condition associated with a similar risk of death as recognized MI. It is unknown why some persons experience MI with few or no symptoms; however, one possible explanation is attenuated pain sensitivity. To our knowledge, no previous study has examined the association between pain sensitivity and recognition of MI.
<b>Methods ...
Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)
Objective - The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.<p>
<p>Methods and results - We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that ...
Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
Background
Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and
health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and
mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This
may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism
(SNP) of the vitamin D receptor ...
The DBP Phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-18)
Background and Objective
In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect
lipid metabolism, inflammation and carcinogenesis. There are three common variants
of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/
1f, 1s/2, 1f/1f, 1f/2, and 2/2). These phenotypes can be identified by genotyping for the two
single ...
The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single
nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the
rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is
causal, one could also expect rs4704397 genotypes to predict CVD and possibly ...