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Responsibilities with conflicting priorities: A qualitative study of ACT providers’ experiences with community treatment orders
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-18)
<p><i>Background - </i>Patients with severe mental illness may be subjected to Community Treatment Orders (CTOs) in order to secure that the patients adhere to treatment. Few studies have investigated the use of CTOs within an Assertive Community Treatment (ACT) setting, and little is known about how the tension between the patients’ autonomy and the clinicians’ responsibility to act in the patients’ ...
Regular physical activity and risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-05)
Venous thromboembolism (VTE) is a complex multifactorial disease that represents a growing public health concern. Identification of modifiable risk factors at the population level may provide a measure to reduce the burden of VTE. In this review, we summarize current knowledge of the role of physical activity on the risk of VTE and VTE-related complications. We also discuss methodological challenges ...
The Influence of Military Identity on Work Engagement and Burnout in the Norwegian Army Rapid Reaction Force
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
The present study examined the influence of military identity on work engagement and burnout among members in the Norwegian Army Rapid Reaction Forces (RRF). Hierarchical regression analyses found work engagement to be predicted by military identity (positively so by professionalism, and negatively by individualism), with individualism also predicting burnout. This is the first study to examine the ...
Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-23)
Abstract
Oncolytic peptides and peptidomimetics are being optimized for the treatment of cancer by selecting agents with
high cytotoxic potential to kill a maximum of tumor cells as well as the capacity to trigger anticancer immune
responses and hence to achieve long-term effects beyond therapeutic discontinuation. Here, we report on the
characterization of two novel oncolytic peptides, DTT-205 ...
Sex-Differences in Children Referred for Assessment: An Exploratory Analysis of the Autism Mental Status Exam (AMSE)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)
The autism mental status exam is an eight-item observational assessment that structures the way we observe and document signs and symptoms of ASD. Investigations of test performance indicate strong sensitivity and specificity using gold-standard assessment as reference standard. This study aims to explore potential sex differences in AMSE test performance and observations of 123 children referred ...
Drug permeability profiling using cell-free permeation tools: Overview and applications
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)
Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
<p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p>
<p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive ...
Fractional integral-like processing in retinal cones reduces noise and improves adaptation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-04)
In the human retina, rod and cone cells detect incoming light with a molecule called rhodopsin. After rhodopsin molecules are activated (by photon impact), these molecules activate the rest of the signalling process for a brief period of time until they are deactivated by a multistage process. First, active rhodopsin is phosphorylated multiple times. Following this, they are further inhibited by the ...
Effects of transcranial direct current stimulation for treating depression: A modeling study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
<p><i>Background</i>:
Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data.</p>
<p><i>Methods</i>:
We used 38 head ...
Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Purpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be
involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective
studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting
results.<br>
Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the
Ovarian Cancer ...