Introduction - Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in serum of asymptomatic subjects that later develop LC. Here we searched for novel microRNA biomarkers in blood from non-cancer, ever-smokers populations up to eight years before diagnosis.<p> <p>Methods - Serum samples from 98,737 subjects from two prospective ...

Purpose - The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?<p> <p>Methods - A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals ...

A few months ago, a letter to the editor was submitted by Dr. Axel Wiebrecht, a highly respected expert in Chinese Herbal Therapy, particularly known for his emphasis on safety. Dr. Wiebrecht is also actively involved as a reviewer for Complementary Medicine Research (CMR). According to CMR's guidelines for authors “Letters may explore subjects related to matters discussed in the journal, providing ...

Background - The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes.<p> <p>Methods - Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover ...

Background. The lifetime prevalence of suicide is around 5% in patients with schizophrenia. Non-adherence to antipsychotic medication is an important risk factor, but prospective studies investigating joint effects of antipsychotic drugs, antidepressants, and benzodiazepines on suicidality are scarce. We aimed to investigate how use and non-use of psychotropic medications are associated with suicidality ...

Background - Fontan circulatory failure with impaired systolic function is well documented; however, its mechanisms are not fully understood. The aim of this study was to explore myocardial functional reserve in adolescent patients with Fontan circulation in response to exercise or acute preload increase.<p> <p>Methods - The study included 32 patients (median age, 16.7 years; range, 15.4–17.9 years; ...

Background During the recent years, emergency services in several countries have integrated video streaming into medical emergency calls, and research on the topic has gained increased focus. Video streaming during medical emergency calls may change dispatcher’s perspective of the call and can be a helpful tool for supervising bystanders’ first aid. Little research exists, however, about the ...

Objective To evaluate population-based data on very preterm infants (<32 weeks gestation) operated for intestinal injuries, focusing on necrotising enterocolitis (NEC) and focal intestinal perforation (FIP).<p> <p>Design Nationwide, population-based registry cohort study. <p>Setting All 21 neonatal units in Norway. <p>Participants All very preterm infants born from 2014 through 2021 and ...

Music therapy has demonstrated significant efficacy in enhancing mental health and well-being. However, labelling music as inherently “therapeutic” may shift its perception from an intrinsic art form to an instrumental tool focused primarily on therapeutic outcomes. This thesis critically examines how this framing influences the perceived intrinsic value of music and shapes musical experiences in ...

Introduction: Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits of their subpopulations.<p> <p>Methods: Using machine learning models, we assessed the clinical association of the CD8+, PD1+, TCF1+ cel l subset by multiplex immunohistochemistry using tissue microarrays in 553 non-small cell ...