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norskDet helsevitenskapelige fakultet: Nye registreringer
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Kan fastleger bidra til å begrense fedmeepidemien? En kvalitativ intervjustudie om fastlegers erfaringer knyttet til utredning og oppfølging av pasienter med overvekt og fedme
(Master thesis; Mastergradsoppgave, 2023-05-20)Størstedelen av den voksne befolkningen i Norge har i dag enten overvekt eller fedme. Dette er multifaktorielle tilstander, som øker risikoen for både fysisk og psykisk uhelse. I Norge søker vi i stor grad å behandle overvekt og fedme i primærhelsetjenesten, hvor fastlegen er pasientens viktigste og oftest første kontakt inn mot helsetjenestene. Formålet med denne studien var å undersøke fastlegers ... -
Body fatness at a young age, weight change and risk of adult pancreatic cancer: The Norwegian Women and Cancer Study
(Master thesis; Mastergradsoppgave, 2021-05-17)Aim: To assess associations between body fatness at a young age, weight change and adult pancreatic cancer risk Material and methods: Self-reported data on body type at age 7, weight at age 18 and weight and height at enrolment were included from 164,488 participants in the Norwegian Women and Cancer (NOWAC) cohort. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% ... -
A national outbreak of Serratia marcescens complex: investigation reveals genomic population structure but no source, Norway, June 2021 to February 2023
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-02-06)We report a national outbreak of Serratia marcescens complex type 755 (ct755) in Norway, with 74 cases identified between June 2021 and February 2023. Careful reviews of patient journals and interviews were performed, involving 33 hospitals throughout Norway. All available clinical isolates of S. marcescens collected between January 2021 and February 2023 (n=455, including cases) ... -
Interaction in Clinical Consultations with Chronically Ill Patients: Cultural Perspectives
(Doctoral thesis; Doktorgradsavhandling, 2025-06-05)Chronic musculoskeletal pain presents significant challenges for patients, clinicians, and healthcare systems, particularly due to the lack of clear prognosis, diagnosis, and etiological explanations, which increases uncertainty in consultations. This dissertation explores interactions in consultations with this patient group at a specialized rehabilitation clinic in Norway. The goal is to gain ... -
Eat, Deliver, Destroy: How Liposomes and Phagocytes Team Up. Harnessing liposome - phagocyte interactions for enhanced drug delivery, imaging, and cancer immunotherapy
(Doctoral thesis; Doktorgradsavhandling, 2025-06-04)Cancer remains a major health challenge, with over 19.3 million new cases diagnosed in 2020. Conventional treatments like chemotherapy and radiation face limitations such as toxicity, resistance, and poor targeting. This thesis explores nanomedicine-based immunomodulation strategies, focusing on liposomes to enhance drug delivery to immune cells. Liposomes are nano-sized vesicles that encapsulate ... -
Design and optimization of liposomal formulation intended for phagocyte targeting in cancer treatment
(Master thesis; Mastergradsoppgave, 2023-05-15)For the first time, we have developed a liposomal formulation for Nω-hydroxy-nor-L-arginine (nor-NOHA). nor-NOHA is an arginase inhibitor that has potential in cancer treatment. The work aimed to develop a formulation that would have high encapsulation efficiency (EE%) for nor-NOHA in liposomes. Optimization of liposomes was conducted stepwise, namely liposomal characteristics were investigated ... -
The association between the energy-adjusted Dietary Inflammatory Index (E-DII) and risk of Type 2 Diabetes Mellitus in the Norwegian Women and Cancer Study (NOWAC)
(Master thesis; Mastergradsoppgave, 2023-05-15)Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing worldwide. There are several reasons for the growing prevalence, including sedentary lifestyles and increased consumption of unhealthy diets. Inflammation is the immune system’s natural reaction to injury or infection and is suggested to play a key role in the pathogenesis of T2DM. The energy-adjusted dietary ... -
Lipid Nanoparticle Enabled Co-Delivery of Tetrahedral DNA Framework and Antimicrobial Peptides
(Mastergradsoppgave; Master thesis, 2023-05-15)In the context of persistent wound infections, the delivery of antimicrobial agents is challenging. The bacterium in skin presents several strategies to avoid antimicrobial exposure by hiding inside cells and via the formation of biofilms. Additionally, several virulence strategies facilitate the progression of persistent bacterial infections. Although antibiotics are considered very advanced, they ... -
A study on CLTA and its interaction with ATG8 proteins
(Mastergradsoppgave; Master thesis, 2023-05-15)Autophagy is an essential cell mechanism for cell survival, where damaged organelles, misfolded proteins and invading pathogens can be broken down and the materials recycled. This process is dependent on double-membrane structures called autophagosomes engulfing and trafficking the contents to lysosomes for degradation. Proper formation of autophagosomes is therefore important in order to keep the ... -
Effect of PEGylation in liposomal protein corona formation. Characterization of in vitro protein corona formation and the effect of protein corona on cellular uptake of pH-sensitive liposomes in glioblastoma cells
(Master thesis; Mastergradsoppgave, 2023-05-15)Glioblastoma is the most lethal brain cancer, characterized by rapid growth and high mortality. Despite advances in diagnosis, surgery, and radiation therapy, glioblastoma remains resistant to treatment. One of the keys to successful anticancer drugs is their ability to reach the target site while minimizing accumulation in other tissues. Most drugs lack the physical and chemical properties and ... -
Modulation of cAMP levels by β-stimulation and PDE3 inhibition during hypothermia. An in vitro study on embryonic cardiac cells from rat
(Master thesis; Mastergradsoppgave, 2022-05-15)Introduction: Accidental hypothermia is defined as an involuntary drop in core body temperature below 35 °C and is associated with acute cardiac dysfunction. The PDE3 inhibitor milrinone and β-agonist isoprenaline provide positive inotropic effects during normothermia by elevating intracellular levels of cAMP in cardiac cells. Rat models have demonstrated that milrinone has more favorable hemodynamic ... -
Liposomal Nω-hydroxy-l-norarginine, a proof-of-concept: Arginase inhibitors can be incorporated in liposomes while retaining their therapeutic activity ex vivo
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-08)Cancer immunotherapy has evolved significantly over the last decade, with therapeutics targeting the adaptive immune system showing exciting effects in clinics. Yet, the modulation of the innate immune system, particularly the tumor-associated innate immune cells which are an integral part of immune responses in cancer, remains less understood. The arginase 1 (Arg1) pathway is a pivotal metabolic ... -
Exploring the potential effects of PFAS exposure on biomarkers: Insights from legacy PFAS and oxidizable precursors on blood lipids, DNA methylation, and gene expression
(Doctoral thesis; Doktorgradsavhandling, 2025-05-28)Humans are exposed to numerous chemicals daily, including per- and polyfluoroalkyl substances (PFAS), a class of synthetic compounds that have dominated human exposure for decades. These highly persistent chemicals are widely used in industrial and consumer products and are among the most prevalent contaminants detected in human blood. While some legacy PFAS have been phased out due to increasing ... -
Application of outer membrane vesicles from ESKAPE pathogens as native models of bacterial membranes
(Mastergradsoppgave; Master thesis, 2023-05-14)The antimicrobial resistance crisis has led to the emergence of multidrug-resistant pathogens, posing a significant threat to public health. To address this crisis there is an ongoing search for new antimicrobial substances. To facilitate this search and to understand the nature of antimicrobial resistance better it is crucial to develop representative models of bacterial membranes and efficient ... -
Education and adherence to the Norwegian Dietary Recommendations. Insights from The Tromsø Study 2015-2016
(Master thesis; Mastergradsoppgave, 2023-05-14)Background: Socioeconomic differences are observed in health and diet, and higher education is associated with a healthier diet. The Norwegian dietary recommendations contain 13 recommendations for food, drinks, supplements, and physical activity. Aim: The aim was to investigate if the intake of food groups from – and adherence to - the dietary recommendations was different across educational ... -
Hypothetical target trial emulation assessing of combination pembrolizumab with chemotherapy in NSCLC with frail patients
(Mastergradsoppgave; Master thesis, 2024-05-14)Real-world data (RWE) may enable the investigation of patients who are ineligible for Randomized Controlled Trials (RCT) due to poor performance status, old age, or comorbidities. In addition, it permits research that may be impossible through prospective design due to ethics or feasibility. Hypothetical target trial emulation(hTTE) has emerged as a new method that uses RWD to evaluate new drugs' ... -
Physical activity, endurance sport practice, atrial fibrillation, and prevention of adverse events: The Norwegian Exercise in Atrial Fibrillation Study (NEXAF)
(Doctoral thesis; Doktorgradsavhandling, 2025-05-27)Atrial fibrillation (AF), the most common arrhythmia worldwide, is associated with an increased risk of stroke and mortality. Low to moderate physical activity (PA) levels are associated with a reduced AF risk. Conversely, high PA is associated with an increased risk. Thus, it is unclear whether the beneficial effect of high PA is offset by an increased AF risk. Furthermore, the impact of PA on ... -
Synthesis of linear and cyclic proline-rich analogues of the marine, antimicrobial peptides Hyasin 1 and Arasin 1. Impact of antimicrobial peptide modifications on bioactivity and toxicity
(Master thesis; Mastergradsoppgave, 2022-05-13)Since the introduction of antimicrobial agents in the 1940s, antimicrobial resistance has increasingly become a major concern. New resistance mechanisms have emerged and threatened our ability to treat common infections. Currently, antimicrobial resistance is rising to higher levels in all parts of the world and the need of novel therapeutics is increasing. As a contribution to antimicrobial drug ... -
The potential of ChatGPT as a learning tool. A randomized controlled trial of pharmacy students in Tromsø
(Master thesis; Mastergradsoppgave, 2024-05-12)Background: Pharmacy education is evolving with technological advances and changing student needs, incorporating digital tools alongside traditional methods. Artificial intelligence (AI), particularly large language models like ChatGPT, offers interactive learning and real-time feedback, shifting from passive to active learning. However, there is a notable lack of research-based evidence on ChatGPT’s ... -
Understanding how community pharmacist play a role in self-medication with antibiotics in Kumasi, Ghana.
(Mastergradsoppgave; Master thesis, 2024-05-15)Background: Non-prescription antibiotic dispensing is a widespread phenomenon observed predominantly in low- and middle-income countries (LMICs) and low-income countries (LICs). This practice is associated with inappropriate sale and usage of antibiotics, contributing significantly to the global challenge of antibiotic resistance. Aim: The aim of the study is to investigate how the pharmacist ...
