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Effects of transcranial direct current stimulation for treating depression: A modeling study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-28)
<p><i>Background</i>:
Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data.</p>
<p><i>Methods</i>:
We used 38 head ...
Blinding is compromised for transcranial direct current stimulation at 1 mA for 20 min in young healthy adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-19)
Transcranial direct current stimulation (tDCS) is a non‐invasive brain stimulation method that is frequently used to study cortical excitability changes and their impact on cognitive functions in humans. While most stimulators are capable of operating in double‐blind mode, the amount of discomfort experienced during tDCS may break blinding. Therefore, specifically designed sham stimulation protocols ...
Linking brain networks and behavioral variability to different types of mind-wandering
(Others; Andre, 2017-07-13)
Intermittent Absence of Control during Reinforcement Learning Interferes with Pavlovian Bias in Action Selection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-02)
The ability to control the occurrence of rewarding and punishing events is crucial for our well-being. Two ways to optimize performance are to follow heuristics like Pavlovian biases to approach reward and avoid loss or to rely more on slowly accumulated stimulus–action associations. Although reduced control over outcomes has been linked to suboptimal decision-making in clinical conditions associated ...
The interplay between executive control, behavioral variability and mind wandering: Insights from a high-definition transcranial direct-current stimulation study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-21)
While the involvement of executive processes in mind wandering is largely undebated, their exact relationship is subject to an ongoing debate and rarely studied dynamically within‐subject. Several brain‐stimulation studies using transcranial direct current stimulation (tDCS) have attempted to modulate mind‐wandering propensity by stimulating the left dorsolateral prefrontal cortex (DLPFC) which is ...
Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation [version 2; referees: 2 approved]
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-06)
During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized ...
Transcranial Direct Current Stimulation above the Medial Prefrontal Cortex Facilitates Decision-Making following Periods of Low Outcome Controllability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-25)
Recent studies suggest that choice behavior in reinforcement learning tasks is shaped by the level of outcome controllability. In particular, Pavlovian bias (PB) seems to be enhanced under low levels of control, manifesting in approach tendencies toward rewards and response inhibition when facing potential losses. The medial prefrontal cortex (mPFC) has been implicated both in evaluating outcome ...
The effect of transcranial direct current stimulation on the interplay between executive control, behavioral variability and mind wandering: A registered report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-11)
Mind wandering (MW) is a mental phenomenon humans experience daily. Yet, we lack a complete understanding of the neural basis of this pervasive mental state. Over the past decade there has been an increase in publications using transcranial direct current stimulation (tDCS) to modulate the propensity to mind wander, but findings are diverse, and a satisfactory conclusion is missing. Recently, Boayue ...
Increasing propensity to mind‐wander by transcranial direct current stimulation? A registered report
(Journal article; Tidsskriftartikkel, 2019-01-24)
Transcranial direct current stimulation (tDCS) has been proposed to be able to modulate different cognitive functions. However, recent meta‐analyses conclude that its efficacy is still in question. Recently, an increase in subjects’ propensity to mind‐wander has been reported as a consequence of anodal stimulation of the left dorsolateral prefrontal cortex (Axelrod et al., Proceedings of the National ...
Probing the neural signature of mind wandering with simultaneous fMRI-EEG and pupillometry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)
Mind wandering reflects the shift in attentional focus from task-related cognition driven by external stimuli toward self-generated and internally-oriented thought processes. Although such task-unrelated thoughts (TUTs) are pervasive and detrimental to task performance, their underlying neural mechanisms are only modestly understood. To investigate TUTs with high spatial and temporal precision, we ...