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Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors

dc.contributor.authorWitowska-Jarosz, Janina
dc.contributor.authorJaronczyk, Malgorzata
dc.contributor.authorMazurek, Aleksander P
dc.contributor.authorSylte, Ingebrigt
dc.contributor.authorBojarski, Andrezej J
dc.contributor.authorChilmonczyk, Zdzislaw
dc.contributor.authorJarosz, Maciej
dc.date.accessioned2013-03-13T10:36:27Z
dc.date.available2013-03-13T10:36:27Z
dc.date.issued2012
dc.description.abstractSix synthesized 6-nitroquipazine derivatives were examined by electron ionization (EI) and electrospray ionization (ESI) mass spectrometry in positive and negative ion mode. The compounds exhibit high affinity for the serotonin transporter (SERT) and belong to a new class of SERT inhibitors. The EI mass spectra registered in negative ion mode showed prominent molecular ions for all the compounds studied. All EI mass spectra and all ESI mass spectra showed similar fragmentation pathways of molecular ions, but the pathways differed between EI and ESI. The differences were explained with the aid of theoretical evaluation of the stability of the respective radical ions (EI MS) and protonated ions (ESI MS).en
dc.identifier.citationAnalytical and Bioanalytical Chemistry 402(2012) nr. 1 s. 537-541en
dc.identifier.cristinIDFRIDAID 926956
dc.identifier.doihttp://dx.doi.org/10.1007/s00216-011-5410-8
dc.identifier.issn1618-2642
dc.identifier.urihttps://hdl.handle.net/10037/4983
dc.identifier.urnURN:NBN:no-uit_munin_4724
dc.language.isoengen
dc.publisherSpringer Verlagen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical biochemistry: 726en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en
dc.titleMass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitorsen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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