Now showing items 697-697 of 697

    • Zinc binding and chelating compounds as inhibitors of bacterial metalloproteases and human matrix metalloproteases 

      Rahman, Fatema Amatur (Doctoral thesis; Doktorgradsavhandling, 2023-10-13)
      Bacterial multi-drug resistance is a major health problem worldwide. Inhibition of bacterial virulence is suggested to be a promising strategy in the development of new antibacterial drugs. The present work has focused on identifying new inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN, LasB) and aureolysin (ALN), which are all zinc metalloproteases (MPs) using enzyme ...