Acute intermittent porphyria (AIP) is a rare autosomal dominant inherited metabolic disease with lowered function of the enzyme hydroxymethylbilan synthase due to mutation in this gene of the heme synthesis. The resulting excess of aminolevulinic acid and porphobilinogen can result in acute abdominal pain, paresis, fatigue, increased risk for kidney failure and hepatocellular carcinoma. Some drugs, ...

<p><i>Background:</i> In suicidological research, it is well known that suicide rates differ, sometimes to a great extent, between countries, sexes, religious and ethnic populations. It has been suggested that in-depth exploration of social, cultural, contextual and historical perspectives on suicide is needed to explain this, and increase efficacy of prevention efforts. Sámi are the Indigenous ...

<p>The aim of the ethnographic study described was to listen sensitively and give voice to elderly Arctic women’s personal food biographies and everyday experiences of living in small coastal towns and inland areas of Norway’s Circumpolar North, North West Russia and Greenland. These specified geographical contexts were selected because they have been the focus of the Arctic and Global Health research ...

Venøs tromboembolisme (VTE) er en fellesbetegnelse på dyp venetrombose (DVT) og lungeemboli (LE). VTE er en vanlig og alvorlig karsykdom hvor forekomsten har vært svakt økende de siste årene. Marine omega-3 fettsyrer (n-3 PUFAs) har flere gunstige effekter på hemostasemekanismen. Målet med denne doktorgradsavhandlingen var å undersøke sammenhengen mellom inntak av marine n-3 PUFAs i kosten og risikoen ...

The two major forms of Inflammatory bowel disease (IBD), Ulcerative Colitis (UC) and Crohn’s Disease (CD), are characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host-microbe interaction. This overwhelming complexity makes IBD ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient ...

Decentralised services using outreach clinics or modern technology are methods to reduce the patient burden by reducing transport time and costs to the health care system. The aim of this study was to evaluate the quality of planned remote orthopaedic consultations with the help of videoconferences. From 2007 to 2012, we performed a randomised controlled trial (RCT) with two parallel groups: ...

Until the late 1990s, the Burch colposuspension was considered the gold standard for the surgical treatment of stress urinary incontinence (SUI) and stress-dominated mixed urinary incontinence (MUI) in women. In 1996, Ulmsten introduced the minimally invasive retropubic tension-free vaginal tape (TVT) procedure, and the first case series reported high safety and effectiveness of this procedure at ...

Persistent bodily symptoms without medical clarity creates many layers of uncertainty both for health professionals and for patients. In primary care, research has shown that clinical encounters of medically unexplained symptoms (MUS) are highly contentious, sometimes causing adverse effects. However, little is known about communicative challenges for adolescents in specialist health care settings; ...

Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. More than 80% of MCC have Merkel cell polyomavirus (MCPyV) clonally integrated into the human genome (VP-MCC) while the remaining 20% are virus negative (VN-MCC) but linked with chronic exposure to UV sunlight. MCC is particularly associated with immune suppression with 8-48 folds increase in incidence in immunosuppressive ...

<p><i>Background: </i>This thesis focuses on diagnostic imaging in potentially severely injured patients admitted to the University Hospital of North Norway. Imaging is important for timely initiation of treatment and survival after trauma. The use of standardized whole body computer tomography (SWBCT) is increasing. However, the ionizing radiation used may cause a small risk for induction of cancer ...