It is estimated that 5-10% of breast cancers (BC) and 25% of ovarian cancers (OC) are caused by inherited sequence variants in genes. In the mid 90’s, the two genes BRCA1 and BRCA2 were discovered to be directly associated with increased risk of BC and OC. Molecular screening of these two genes has revealed several disease causing variants as well as variants of unknown clinical significance (VUS). ...

Venous thromboembolism (VTE) is a common disease with an incidence of 1–2 per 1000 individuals. VTE is a collective term for deep vein thrombosis and pulmonary embolism. Extracellular vesicles (EVs) are lipid-membrane-bound spherical vesicles that bud off from the cells upon activation and apoptosis. Their size varies between 30 nm and 1 μm. Recent advances in experimental and observational studies ...

This thesis provides empirical insights about socio-technical interdependencies affecting the making and scaling of an Information Infrastructure (II) for healthcare based on the development of large-scale Electronic Patient Records. The Ph.D. study is an interpretive case study, where the empirical data has been collected from 2012 to 2017. In most developed countries, the pressures from politicians ...

Despite advances in therapies, assessment of fracture risk, and diagnosis of bone fragility, few women and men with high fracture risk receive treatment, even after they develop fracture. To be able to recognize and identify subjects who are at risk for fragility fracture, and to target treatment well, it is important to search for risk factors that are associated with, or ideally, predict fracture. ...

Mange gjennomgår et hjerteinfarkt uten å vite at det har skjedd, dette kalles stumme hjerteinfarkt. Det er ikke kjent hvorfor noen rammes av stumme hjerteinfarkt, mens andre opplever brystsmerter og tar kontakt med lege. I Tromsøundersøkelsens 6.runde ble 6,199 personer undersøkt med EKG, der man kan se om en person har gjennomgått et hjerteinfarkt. I tillegg ble det samlet inn data på smertefølsomhet ...

Pain is common in otherwise healthy youth and is often associated with psychosocial problems. However, there is limited knowledge of how pain-troubled adolescents fare from adolescence into young adulthood. To examine this, the Norwegian Arctic Adolescent Health Study, a 10th grade school-based survey (15–16-year-olds) conducted in North Norway, in 2003–2005, was linked to the Norwegian Patient ...

Wild rats employ a rather extensive area for their daily activities and share elaborate burrows with tunnel and chambers. When a female enters estrus, she will copulate with multiple males during the entire period of estrus. In a typical laboratory setting, rat sexual behavior is studied in pairs of opposite sex individuals. Apparently the experimental studies have been performed in this highly ...

Epidemiological data have disclosed a considerable reduction in caries prevalence among children and adolescents in Western countries including Norway for over 40 years. Concomitantly, enamel caries has received increased focus in order to give a better picture of the complete need for dental treatment, non-operative as well as operative. More recently, dental erosive wear seems to be a growing ...

This thesis aims to: i) explore the importance of preference-weighting in health state utility (HSU) instruments and ii) examine the contribution of policy-relevant factors to subjective well-being (SWB). The analyses herein are based on an international sample of individuals aged 18 and above, and this thesis comprises three papers. Paper 1 examined the relative importance of preference-weighting ...