Doktorgradsavhandlinger (Helsefak): Recent submissions
Now showing items 501-520 of 723
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Fractional exhaled nitric oxide and its relation to exercise, asthma and allergic rhinoconjunctivitis in a subarctic childhood population. A study of asthma and allergy among schoolchildren in Nordland County.
(Doctoral thesis; Doktorgradsavhandling, 2014-11-07)Astma og allergisk øye- og nesekatarr (rhinokonjunktivitt, AR) er de vanligste kroniske sykdommene blant barn i den vestlige verden. I de siste tiårene har prevalensen (forekomsten) av sykdommene økt betydelig, men i enkelte Europeiske land rapporteres det om en utflating i prevalensen av astma. I klinisk praksis brukes laboratorietester til å understøtte diagnosene astma og AR. Analyser av biologiske ... -
Serum gamma-glutamyltransferase: Determinants and diagnostic Characteristicsin relation to interventionon risk drinkers
(Doctoral thesis; Doktorgradsavhandling, 1992) -
Cardiovascular risk factors, atherosclerosis and venous thromboembolism - The Tromsø study
(Doctoral thesis; Doktorgradsavhandling, 2014-12-22)Venous thromboembolism (VTE) is a common and potentially fatal disease, often occuring in the absence of obvious predisposing factors. Recent observational studies in selected populations have suggested a closer association between arterial thrombosis (myocardial infarction (MI) and stroke) and VTE, two disease entities considered separate in terms of pathophysiology, epidemiology and treatments. ... -
Mitogen-activated protein kinase-activated protein kinase 5 - Structure, function and inhibition
(Doctoral thesis; Doktorgradsavhandling, 2014-09-26)Protein kinases have become central in the efforts to understand the nature of various diseases, and a lot is invested into creating effective therapeutic strategies and finding effective and selective protein kinase inhibitors. In order to succeed it is also important to focus on the structure of the kinases, their exact biological role, and how they interact and cooperate in the signaling. The ... -
The Clinician in Leadership. Perceptions of Style. Perspectives from Rural Primary Medicine in Norway.
(Doctoral thesis; Doktorgradsavhandling, 2014-08-22) -
Designing national electronic services in the public healthcare sector.
(Doctoral thesis; Doktorgradsavhandling, 2014-12-12)This thesis deals with a socio-technical approach towards the development of inter-organisational ICT tools in healthcare. My overall case is Norwegian healthcare, and I investigated how national inter-organisational ICT tools were developed and why good results were difficult to achieve. Three public projects make up the basis of my data collection in which the main categories of data are interviews, ... -
Safe Blood Transfusion: Screening for Hepatitis B and Hepatitis C Virus Infections in Potential Blood Donors in Rural Southeast Asia
(Doctoral thesis; Doktorgradsavhandling, 2014-11-06)2,400 blood samples from potential voluntary rural blood donors in a multicentre cross-sectional study in Cambodia and Vietnam were analysed with rapid and EIA tests for detection of HBsAg, anti-HBc and anti-HCV at local laboratories. 640 randomly selected blood samples were blindly validated in a Norwegian accredited micro-laboratory by a chemiluminescent micro particle immunoassay technique (CMIA). ... -
Charcot-Marie-Tooth disease (CMT): statistical analysis and revision of molecular genetic diagnostics in a patient population and identification of the disease locus in a large Norwegian family with CMT.
(Doctoral thesis; Doktorgradsavhandling, 2014-09-19)CMT is a common inherited disease of the peripheral nerves that may be caused by mutations in multiple genes, most are rare. Our aim was to describe the spectrum of mutations and genes in Norwegian CMT patients, identify factors associated with diagnostic findings, revise the testprotocol, and evaluate the assessments of genetic variants of uncertain clinical significance. Furthermore, we searched ... -
Managing childhood obesity, The Finnmark Activity School
(Doctoral thesis; Doktorgradsavhandling, 2014-12-11)Childhood obesity has reached epidemic proportions globally and represents a major threat to children’s health. Data on effectiveness of treatment programs for childhood obesity beyond one year is limited and there is little high-quality evidence to recommend one treatment over another. The objective of the clinical trial The Finnmark Activity School was to compare a new multidisciplinary approach ... -
Cancer-related venous thromboembolism: epidemiology and risk factors
(Doctoral thesis; Doktorgradsavhandling, 2014-11-28)The association between cancer and venous thromboembolism (VTE) was described already in the 19th century and cancer has later been acknowledged as one of the most important risk factors for VTE. Population-based studies on the subject with information about confounders and validated endpoints are lacking. The first aim of this thesis was to estimate the frequency of VTE among cancer patients in a ... -
A study of some biological factors of importance to geriatric psychiatry.
(Doctoral thesis; Doktorgradsavhandling, 2014-09-12)Det er lite kunnskap om vitamin D og sink mangel hos eldre med psykiske lidelser. I en case-control studie fant vi signifikant lavere serum nivå av 25(OH)D i en eldre (>64 år) pasient gruppe sammenlignet med en eldre kontroll gruppe (40.5 nmol/L vs. 65.9 nmol/L). Prevalens av vitamin D mangel (def: 25(OH) D<50 nmol/L) var 71.6% i pasient gruppen mot 20.0% i kontroll gruppen. Det var ikke forskjell ... -
Molecular determinants involved during Staphylococcus aureus colonization and/or infection
(Doctoral thesis; Doktorgradsavhandling, 2014-09-26)Given the link between the compelling impact of Staphylococcus aureus colonization on the risk and outcome of infection, strategies to prevent nasal colonization could be an appealing method of fighting infection. The ability of S. aureus to colonize and infect a host is a balance between its multitudes of virulence factors and the host immune defence mechanisms. Despite the multiple bacterial factors ... -
Investigation of the antiviral effects of artesunate on BK and JC polyomavirus replication
(Doctoral thesis; Doktorgradsavhandling, 2014-09-19)The ubiquitous human BK and JC polyomaviruses cause the diseases polyomavirus-associated nephropathy, hemoragic cystitis and progressive multifocal leukoencephalopathy in immunosuppressed patients. There are no antiviral drugs for these diseases which often lead to kidney graft loss, severe disability and premature death. As a first step in the evaluation of the malaria drug artesunate as a future ... -
Å få og å ta i bruk eit teknisk hjelpemiddel - ei gåtefull reise. Ei kvalitativ undersøking av heimebuande eldre sine erfaringar.
(Doctoral thesis; Doktorgradsavhandling, 2014-09-26)Formidling av tekniske hjelpemiddel er eit hyppig brukt verkty for å gjere eldre i stand til å bu heime så lenge som mogleg. Likevel veit ein lite om korleis eldre erfarer det å få og å ta i bruk tekniske hjelpemiddel. Kunnskap om erfaringane til brukarar av hjelpemiddel kan bidra til ei vidareutvikling av klientsentrerte og effektive helsetenester. Formålet med prosjektet var difor å undersøkje ... -
Aspects of Active Smoking and Breast Cancer
(Doctoral thesis; Doktorgradsavhandling, 2014-10-24)Summary: According to the WHO, breast cancer is by far the most frequently diagnosed cancer, and the most frequent cause of cancer death among women in the world. Tobacco smoking is the single largest cause of cancer worldwide and has been linked to cancer in most organ systems. The aim of this thesis was to illuminate the association between smoking and breast cancer incidence, mortality, and to ... -
Associations of widespread pain sensitivity, comorbid chronic pain and psychological distress with Irritable Bowel Syndrome and abdominal pain
(Doctoral thesis; Doktorgradsavhandling, 2014-09-25)This is the first report documenting widespread hyperalgesia among adolescent and adult individuals with symptoms of IBS in the general population. Results were found to be independent of sex, comorbid pain and psychological distress. Increased pain sensitivity may contribute in triggering and maintaining chronic pain, but prospective studies are needed to examine these possible causal relationships. The ... -
Tumor hypoxia and hypoxic markers in non-small cell lung cancer
(Doctoral thesis; Doktorgradsavhandling, 2014-03-14) -
Cardiovascular adaptation in pregnancy - Effects of angiotensin II, transverse aorta constriction and high-intensity interval training on pregnant rats
(Doctoral thesis; Doktorgradsavhandling, 2014-09-18)Objectives: To investigate how cardiac function, remodeling and gene expression are affected in pregnancy in response to cardiovascular stress, to detect possible adverse effects on the fetus, and to evaluate if coronary endothelial function is influenced by pregnancy and increased cardiac afterload. Methods: Pregnant and non-pregnant rats were subjected to chronic AngII-infusion, transverse aortic ... -
Genetic Susceptibility, Lifestyle, Ovarian Hormones, and Mammographic Density – key factors in breast cancer development. The Norwegian Energy Balance and Breast Cancer Aspects-I Study.
(Doctoral thesis; Doktorgradsavhandling, 2013-02-28)Breast cancer is the most frequent cancer among women worldwide. Over the last century, the prevalence of overnutrition, overweight and obesity has increased, age at menarche has dropped and age at birth of first child has risen among women in Western countries. These trends may be linked to exposure to ovarian hormones that, in turn, may affect a woman’s lifetime risk of getting breast cancer. The ... -
Implementing interventions in adult mental health services to identify and support children of mentally ill parents.
(Doctoral thesis; Doktorgradsavhandling, 2014-03-28)This dissertation is a result of a large-scale longitudinal project (the BAP-study) where the overall aim was to monitor and evaluate the implementation of clinical change to identify and support children of mentally ill parents within the participating clinic. The design includes a pre-test, post-test and one-year follow-up. The first stage of the study involved assessment of the status quo in the ...