Doktorgradsavhandlinger (Helsefak): Nye registreringer
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A short-form personality measure for military personnel selection: Psychometric investigation and perspectives on usage
(Doctoral thesis; Doktorgradsavhandling, 2022-05-20)This doctoral thesis aimed to evaluate the psychometric properties and the practical use of a newly developed self-report personality measure for the Armed Forces, the Norwegian Military Personality Inventory (NMPI). Three published studies contributed to this end. Study 1 explored associations between candidate personality traits and leadership competency ratings at an officer selection program. ... -
A novel dual-task paradigm for evaluating the interplay between gait, cognition, and hearing loss in normal aging and MCI: Effects of Dichotic Listening during overground walking
(Doctoral thesis; Doktorgradsavhandling, 2022-05-12)The association between gait and cognition in aging has been widely studied with the help of dual-task paradigms consisting of walking while simultaneously performing a cognitive task. However, previous dual-task research has lacked consistency in methods. In this doctoral work, we introduced a novel dual-task paradigm including Dichotic Listening (DL) performed concomitantly with walking overground. ... -
Discovery and detection of phase-II metabolites of exogenous steroids in anti-doping analysis
(Doctoral thesis; Doktorgradsavhandling, 2022-04-29)Anti-doping measures are an essential part of professional sports around the world. Anabolic androgenic steroids have been among the most widely used illicit substance classes since the early days of the fight against doping. The conventional method for analysing these substances is gas chromatography combined with mass spectrometry (GC-MS). This approach is sensitive and selective but also very ... -
Multiple sclerosis in Northern Norway, epidemiology and comorbidity
(Doctoral thesis; Doktorgradsavhandling, 2022-04-25)<p><i>Background:</i> Multiple sclerosis (MS) is a severe chronic inflammatory disease in the central nervous system, mainly affecting young adults. The prevalence varies between different parts of the world, but the general rule is that it increases with increasing latitude. Studies on comorbid conditions in MS are limited, but this topic have gained increasing interest. <p><i>Aims:</i> To describe ... -
Molar-Incisor Hypomineralization (MIH). Prevalence among 16-year-old adolescents: A case-control study of children with a low Apgar score at birth and a study on tooth formation and antibiotics in mice
(Doctoral thesis; Doktorgradsavhandling, 2022-04-22)<p><i>Background/Aims:</i> Molar-Incisor Hypomineralization (MIH) is one of the most common dental developmental disorders with a global prevalence of 13%. The etiology of MIH is still elusive. The aims of this thesis were to report the prevalence of MIH in northern Norway, to investigate a possible association between birth asphyxia and MIH, and to document the effect of antibiotics on the developing ... -
Epigenetics in Inflammatory Bowel Disease. Contribution of DNA methylation to Ulcerative Colitis pathogenesis
(Doctoral thesis; Doktorgradsavhandling, 2022-04-08)Ulcerative colitis (UC) is a chronic, inflammatory disease of the gastrointestinal tract, primarily affecting the colon. Along with Crohn’s disease (CD) they constitute the most common subtypes of inflammatory bowel disease (IBD). Genetic variants can only explain approximately 20 % of all IBD cases, indicating a more complex pathogenesis which is not fully understood. It has been implied that an ... -
Cesarean sections in Georgia and Norway - What contributes to too much, too little, or just right? The role of maternal risk factors and efforts to reduce high cesarean section rates
(Doctoral thesis; Doktorgradsavhandling, 2022-04-06)High rates of cesarean section are associated with increased mortality and morbidity. To decrease cesarean sections without medical indication is complex and requires in-depth knowledge of local context and which groups to target for possible interventions. Our aim was to assess the role of maternal risk factors in relation to cesarean section in Georgia and Norway, two countries with diverging rates ... -
Sex-steroids and social network in relation to Staphylococcus aureus nasal carriage
(Doctoral thesis; Doktorgradsavhandling, 2022-04-01)<i>Staphylococcus aureus</i> (<i>S. aureus</i>) is a human pathogen that can colonize skin and mucosa. Nasal carriage is associated with increased risk of autoinfection and transmission and it is therefore important to identify possible targets for prevention of carriage. Sex and age are the most important risk factors for <i>S. aureus</i> carriage, and hypotheses about sex-steroids as major host ... -
Inflammation, hypertension, and microRNA and Prostate Cancer. The Prostate Cancer throughout life (PROCA-life) study
(Doctoral thesis; Doktorgradsavhandling, 2022-03-31)<p><i>Background/Aims:</i> Prostate cancer (PCa) is the most common cancer among men in Norway as well as world-wide, and a major cause of health loss and death with 1.4 million new cases and 375 000 deaths world-wide in 2020. Biological mechanisms involved in PCa development are mainly unknown, but chronic inflammation, one hallmark of cancer development, has been questioned to play a key role in ... -
Antibiotic Resistance in Oral Streptococci: The prevalence, diversity, stability, and fitness cost of Tn916 -Tn1545 family in oral streptococcal isolates
(Doctoral thesis; Doktorgradsavhandling, 2022-03-25)Oral streptococci are important members of the oral microbiome that are gathering more attention due to the presence of antimicrobial resistance determinants and their association with mobile genetic elements. Mobile genetic elements such as the ICE, Tn916 are abundant in bacterial populations and have been implicated in the spread of antibiotic resistance. Despite their abundance, little is known ... -
Cardiopulmonary Resuscitation and Rewarming from Accidental Hypothermia
(Doctoral thesis; Doktorgradsavhandling, 2022-03-11)This thesis springs from 3 different papers: Paper 1 A randomised controlled study in rats to investigate whether an infusion of crystalloids or colloids during rewarming from hypothermia could alleviate the alterations in cardiovascular function seen in untreated control animals. Paper 2 A randomised controlled study in pigs, examining normothermic vs hypothermic cardiopulmonary resuscitation (CPR). ... -
Treatment success with continuous positive airway pressure or mandibular advancement splints in non-severe obstructive sleep apnea: A randomized controlled clinical trial on sleep quality, health-related quality of life and clinical predictors of treatment success
(Doctoral thesis; Doktorgradsavhandling, 2022-04-04)Obstructive sleep apnea (OSA) is a respiratory sleep-disorder characterized by repeated breathing cessations due to pharyngeal soft tissue collapse, leading to several medical disorders and possibly premature death. Two commonly used treatment alternatives for OSA are continuous positive airway pressure (CPAP) and mandibular advancement splints (MAS). The overall aim of this randomized clinical trial ... -
Come Together: Promoting Work and Well-Being. A study in the framework of the JD-R model
(Doctoral thesis; Doktorgradsavhandling, 2022-03-18)The levels of sickness absenteeism in Norway are extraordinarily high. One of three employees reports that work is partly or fully the reason why they are absent. Regardless of a clear and explicit political goal to reduce sickness absence, previous reforms in Norway have not had much success. In this dissertation, we collected self-report data from thousands of jobholders and performed cross-sectional ... -
Evidence basis for injury prevention in Northwestern Russia: a study from the Population-based Shenkursk Injury Registry
(Doctoral thesis; Doktorgradsavhandling, 2022-02-25)Injuries are the important public health problem worldwide. Good-quality injury data are necessary for the development of effective prevention. The Shenkursk Injury Registry (SHIR) was established in the Shenkursk District, Northwestern Russia in 2015. The SHIR covers all injuries for which medical aid is given at the Shenkursk central district hospital (CDH). Overall aim was to provide an evidence ... -
Aspects on Recanalisation Therapies for Acute Ischaemic Stroke. Long-term survival after thrombolytic treatment with alteplase, endovascular thrombectomy for acute ischaemic stroke and recanalisation therapies for wake-up stroke
(Doctoral thesis; Doktorgradsavhandling, 2022-01-21)Stroke is a leading cause of death and disability worldwide. Approximately 85% of strokes are ischaemic strokes caused by blockage of a brain artery. Recanalisation therapies with thrombolysis (injection of drugs that dissolve the blood clot) and thrombectomy (mechanical removal of the blood clot) have revolutionised acute ischaemic stroke treatment during the last 25 years. Thrombolysis within ... -
Nanocarriers for tailored skin delivery: More than just the carriers?
(Doctoral thesis; Doktorgradsavhandling, 2018-11-23)Skin diseases are among the top 5 most leading diseases causing non-fatal health burden worldwide and strategies to assure more effective treatments are urgently needed. Dermal therapy is very attractive due to the direct administration of the drug at the diseased skin site thus minimizing systemic side effects associated with the oral and parenteral routes. However, the great variety within the ... -
Our climatic environment and pain. Exposure to cold environment at work and the weather in daily life
(Doctoral thesis; Doktorgradsavhandling, 2021-12-20)Chronic pain is a major health challenge, and musculoskeletal pain is among the main contributors to years lived with disability worldwide. Earlier research found an association between cold exposure at work and musculoskeletal pain. However, the literature is scarce, especially regarding chronic pain. It is a common belief that weather affects pain experience, but the literature on this topic is ... -
Accelerometer-measured physical activity in Norwegian adolescents. Results from The Fit Futures Study
(Doctoral thesis; Doktorgradsavhandling, 2021-12-16)This thesis examined the prevalence and patterns of accelerometer-measured physical activity in a cohort of urban-rural older adolescents in Northern Norway, participating in the Fit Futures Study. The thesis also assessed the validity of self-reported physical activity against accelerometer measurements, and explored the association between accelerometer-measured physical activity and subsequent ... -
Shaping the Perception of Risk: Investigating a Paradigmatic Case of Applied Decision Making under Uncertainty
(Doctoral thesis; Doktorgradsavhandling, 2021-12-15)Risk and uncertainty characterise most human endeavours. Whether judging risk when buying a house, making a career change, considering marriage, or simply ordering food at an unfamiliar restaurant, each decision involves evaluating the available evidence to infer the likelihood of negative outcomes. Such decisions are often marked by uncertainty, the condition of incomplete knowledge about the ... -
Medication therapy and treatment goal achievement among persons with coronary heart disease in a general population - Guideline adherence, medication adherence and validation of medication use
(Doctoral thesis; Doktorgradsavhandling, 2021-12-13)<p><i>Aim -</i> To assess the adherence to medication therapy for secondary prevention and achievement of treatment goals in persons with coronary heart disease (CHD) in a general population. <p><i>Methods -</i> This project used data from the seventh wave of the Tromsø Study, alone and linked with data from the Norwegian Prescription database (NorPD). Participants self-reporting CHD were included ...