Persistent bodily symptoms without medical clarity creates many layers of uncertainty both for health professionals and for patients. In primary care, research has shown that clinical encounters of medically unexplained symptoms (MUS) are highly contentious, sometimes causing adverse effects. However, little is known about communicative challenges for adolescents in specialist health care settings; ...

Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. More than 80% of MCC have Merkel cell polyomavirus (MCPyV) clonally integrated into the human genome (VP-MCC) while the remaining 20% are virus negative (VN-MCC) but linked with chronic exposure to UV sunlight. MCC is particularly associated with immune suppression with 8-48 folds increase in incidence in immunosuppressive ...

<p><i>Background: </i>This thesis focuses on diagnostic imaging in potentially severely injured patients admitted to the University Hospital of North Norway. Imaging is important for timely initiation of treatment and survival after trauma. The use of standardized whole body computer tomography (SWBCT) is increasing. However, the ionizing radiation used may cause a small risk for induction of cancer ...

The onset of experiencing symptoms of mental distress, such as depression and anxiety, is most common during the adolescent years, and is concurrent with a measured decrease in physical activity levels. Research on the association between physical activity and mental distress among adolescents find contradictory results, and the field is in need of more longitudinal research with validated measurements. ...

På verdensbasis er hjerte-og karsykdommer en av hovedårsakene til for tidlig død, og fokus på forebyggende tiltak er viktig. Selv om de positive helseeffektene av fysisk aktivitet er godt dokumentert, er det mangelfull kunnskap om sammenhengen mellom fysisk aktivitet, risikofaktorer for hjerte-og karsykdom og død hos urfolk, som eksempelvis samer, som lever under krevende klimatiske forhold i den ...

Lung cancer is the most common cancer in men and the third most frequent in women across the globe, and the leading cause of cancer death worldwide. The rising worldwide incidence of lung cancer among women has raised the possibility of a sex difference in the association between smoking and lung cancer. It has been estimated that approximately 90% of all lung cancer is related to smoking. The ...

<p>Akutt psykose er en alvorlig tilstand. Mennesker med akutt psykose blir vanligvis innlagt på akuttpsykiatriske sengeposter for behandling og nødvendig pleie og omsorg. Formålet med denne avhandlingen er å utforske og å beskrive hva kyndig hjelp gjennom akutt psykose kan være for pasienter innlagt i akutt psykiatriske sengeposter. <p>Avhandlingens teoretiske referanseramme er sykepleietenkning ...

When bacteria are exposed to antibiotics, the rate of killing can slow down dramatically over time. This phenomenon can be observed both in vitro and in vivo. In vitro, the mechanistic explanations for this can be divided into two main categories: antibiotic persistence and heteroresistance. In vivo, both mechanisms thought to contribute to observed slowdowns in the elimination and as a result may ...

Multidrug-resistant (MDR) bacteria, including Escherichia coli, producing extended-spectrum β-lactamase (ESBL), AmpC or carbapenemases, are acknowledged among the most significant global health threats. Growing rates of MDR E.coli can lead to an increase in the use of reserve antimicrobials. Re-introducing “old antimicrobials” could offer a timely solution. This work aimed at evaluating the role of ...

<p><i>Background.</i> About 15% of adults seeking substance use disorder (SUD) treatment also have Attention Deficit Hyperactivity Disorder (ADHD). SUD+ADHD patients often present more severe substance use (SU) and may be more difficult to treat. Research on SUD+ADHD has mostly focused on the reduction of ADHD and SUD symptoms and less on other relevant factors in the context of SUD treatment. ...