The two major forms of Inflammatory bowel disease (IBD), Ulcerative Colitis (UC) and Crohn’s Disease (CD), are characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host-microbe interaction. This overwhelming complexity makes IBD ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient ...

Decentralised services using outreach clinics or modern technology are methods to reduce the patient burden by reducing transport time and costs to the health care system. The aim of this study was to evaluate the quality of planned remote orthopaedic consultations with the help of videoconferences. From 2007 to 2012, we performed a randomised controlled trial (RCT) with two parallel groups: ...

Until the late 1990s, the Burch colposuspension was considered the gold standard for the surgical treatment of stress urinary incontinence (SUI) and stress-dominated mixed urinary incontinence (MUI) in women. In 1996, Ulmsten introduced the minimally invasive retropubic tension-free vaginal tape (TVT) procedure, and the first case series reported high safety and effectiveness of this procedure at ...

Persistent bodily symptoms without medical clarity creates many layers of uncertainty both for health professionals and for patients. In primary care, research has shown that clinical encounters of medically unexplained symptoms (MUS) are highly contentious, sometimes causing adverse effects. However, little is known about communicative challenges for adolescents in specialist health care settings; ...

Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. More than 80% of MCC have Merkel cell polyomavirus (MCPyV) clonally integrated into the human genome (VP-MCC) while the remaining 20% are virus negative (VN-MCC) but linked with chronic exposure to UV sunlight. MCC is particularly associated with immune suppression with 8-48 folds increase in incidence in immunosuppressive ...

<p><i>Background: </i>This thesis focuses on diagnostic imaging in potentially severely injured patients admitted to the University Hospital of North Norway. Imaging is important for timely initiation of treatment and survival after trauma. The use of standardized whole body computer tomography (SWBCT) is increasing. However, the ionizing radiation used may cause a small risk for induction of cancer ...

The onset of experiencing symptoms of mental distress, such as depression and anxiety, is most common during the adolescent years, and is concurrent with a measured decrease in physical activity levels. Research on the association between physical activity and mental distress among adolescents find contradictory results, and the field is in need of more longitudinal research with validated measurements. ...

På verdensbasis er hjerte-og karsykdommer en av hovedårsakene til for tidlig død, og fokus på forebyggende tiltak er viktig. Selv om de positive helseeffektene av fysisk aktivitet er godt dokumentert, er det mangelfull kunnskap om sammenhengen mellom fysisk aktivitet, risikofaktorer for hjerte-og karsykdom og død hos urfolk, som eksempelvis samer, som lever under krevende klimatiske forhold i den ...

Lung cancer is the most common cancer in men and the third most frequent in women across the globe, and the leading cause of cancer death worldwide. The rising worldwide incidence of lung cancer among women has raised the possibility of a sex difference in the association between smoking and lung cancer. It has been estimated that approximately 90% of all lung cancer is related to smoking. The ...

<p>Akutt psykose er en alvorlig tilstand. Mennesker med akutt psykose blir vanligvis innlagt på akuttpsykiatriske sengeposter for behandling og nødvendig pleie og omsorg. Formålet med denne avhandlingen er å utforske og å beskrive hva kyndig hjelp gjennom akutt psykose kan være for pasienter innlagt i akutt psykiatriske sengeposter. <p>Avhandlingens teoretiske referanseramme er sykepleietenkning ...