Optimization of antimicrobial wound dressings: liposomal hydrogels with mupirocin

Abstract

Skin injuries represent an important health problem that needs to be managed properly in order to avoid serious consequences in terms of morbidity, disability and life quality. The current focus in wound therapy is on upholding the moisture balance in the wound bed and protection against pathogenic invasion. Wound dressings in a form of hydrogels incorporating antimicrobials, such as the antibiotic mupirocin, can be applied to control dermal infections and thereby ensure optimal wound healing. Drug-in-liposomes-in-hydrogel may additionally provide prolonged contact between drug and wounded area, reducing the need for frequent application of wound dressing.

Size analysis of sonicated liposomes indicated that the particles were smaller than 300 nm, optimal for topical administration onto the skin. Assessment of anti-biofilm effect of liposomally entrapped and free mupirocin showed that both formulations had an impact on biofilm formation and planktonic bacteria, however no clear advantage of liposomal formulation over free drug was seen.

Liposomal hydrogels in which mupirocin is incorporated in liposomes, are safe and have potential to be used as wound dressing assuring maintenance of a moist wound environment. Chitosan liposomal hydrogels would be recommended for wounds with exudates, as their absorbing properties were better than for Carbopol-based hydrogels.