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dc.contributor.authorBesada, Emilio
dc.contributor.authorNikolaisen, Cathrin
dc.contributor.authorNossent, Johannes C
dc.date.accessioned2013-12-16T09:29:51Z
dc.date.available2013-12-16T09:29:51Z
dc.date.issued2012
dc.description.abstractThis article reviews the characteristics and weaknesses of the rheumatoid factor (RF) assay compared with anticitrullinated peptide antibody (ACPA) testing in the work-up of patients with synovitis. This should lead physicians to change their ordering habits and replace RF by ACPA. For RA diagnosis, good clinical judgement based on clinical history, physical examination and routine laboratory work exceeds the value of RF and ACPA assays. In settings of both low and high pretest probability, the added value of each of these assays is low. In cases with intermediate probability, ACPA assays are superior to immunoglobulin (Ig)M-RF because of their higher specificity, and they should be the first choice in a RA diagnostic work-up. Dual testing brings few additional advantages and increases costs significantly. ACPA and IgM-RF are both imperfect tests; around 30% of patients with manifest RA will test negative in both assays and therefore caution needs to be exercised when interpreting negative results. Since 2009, the anti-cyclic citrullinated peptide (anti-CCP) antibody assay has been the only assay available at our institution for RA work-up, with IgM-RF available on a case-by-case basis for non-RA diseases. This has led to a 70% reduction in RF assays performed annually.en
dc.identifier.citationScandinavian Journal of Rheumatology 41(2012) nr. 2 s. 85-88en
dc.identifier.cristinIDFRIDAID 928655
dc.identifier.doihttp://dx.doi.org/10.3109/03009742.2011.617316
dc.identifier.issn0300-9742
dc.identifier.urihttps://hdl.handle.net/10037/5636
dc.identifier.urnURN:NBN:no-uit_munin_5328
dc.language.isoengen
dc.publisherInforma Healthcareen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759en
dc.titleShould rheumatoid factor in rheumatoid arthritis be sent to Davy Jones's Locker?en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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