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Protein Dynamics Regulates Enzyme Enthalpy-Entropy Balance
(Doctoral thesis; Doktorgradsavhandling, 2015-06-26)Accurate predictions of free energies and the corresponding enthalpies and entropies from computer simulations are invaluable for understanding enzymatic catalysis and drug actions in terms of actual structure activity relationships. To facilitate the management and handling of the enormous amount of data generated when calculating thermodynamic parameters, we have developed a high-throughput interface ... -
Protein kinase selectivity mechanisms and structure assisted drug discovery
(Doctoral thesis; Doktorgradsavhandling, 2012-02-24)Protein fosforylering er en av de viktigste intracellulære signaltransduksjonsmekanismer i eukaryote og er involvert i nesten alle cellulære prosesser. Avvikende kinase aktivitet kan forårsake mange alvorlige sykdommer som diabetes og kreft. Bruk av små molekyler for å modulere protein kinase aktivitet er nå en validert metode for behandling av slike sykdommer. Men imidlertid har kliniske studier ... -
Protein surface softness is the origin of enzyme cold-adaptation of trypsin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Protein-protein binding affinities calculated using the LIE method
(Master thesis; Mastergradsoppgave, 2011-11-15)Absolute binding free energies for the third domain of the turkey ovomucoid inhibitor in complex with Streptomyces griseus proteinase B and porcine pancreatic elastase has been calculated using the linear interaction energy method. -
A Protocol for Single-Molecule Translation Imaging in Xenopus Retinal Ganglion Cells
(Chapter; Bokkapittel, 2020-04-29)Single-molecule translation imaging (SMTI) is a straightforward technique for the direct quantification of local protein synthesis. The protein of interest is fused to a fast-folding and fast-bleaching fluorescent protein, allowing one to monitor the appearance of individual fluorescence events after photobleaching of pre-existing proteins in the cell under investigation. The translation of individual ... -
Protonation-Induced Hyperporphyrin Spectra of meso-Aminophenylcorroles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-06)UV–vis spectrophotometric titrations have been carried out on <i>meso</i>-tris(<i>o/m/p</i>-aminophenyl)corrole (H<sub>3</sub>[<i>o/m/p</i>-TAPC]) and meso-triphenylcorrole (H<sub>3</sub>[TPC]) in dimethyl sulfoxide with methanesulfonic acid (MSA). Monoprotonation was found to result in hyperporphyrin spectra characterized by new, red-shifted, and intense Q bands. The effect was particularly dramatic ... -
Protonation-Induced Hyperporphyrin Spectra of meso-Aminophenylcorroles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-06)UV–vis spectrophotometric titrations have been carried out on <i>meso-</i>tris(<i>o/m/p</i>-aminophenyl)corrole (H<sub>3</sub>[<i>o/m/p</i>-TAPC]) and <i>meso-</i>triphenylcorrole (H<sub>3</sub>[TPC]) in dimethyl sulfoxide with methanesulfonic acid (MSA). Monoprotonation was found to result in hyperporphyrin spectra characterized by new, red-shifted, and intense Q bands. The effect was particularly ... -
A Prototype for continuation-passing orchestration of composite web services
(Master thesis; Mastergradsoppgave, 2007-12-15)Web services enable businesses to deliver services via the Web. In addition, Web services can be used to improve business efficiency, because Web services can often replace manual activities in a business process. A Web service can be composed of other simpler Web services using the abstraction traditionally known as workflows. The process of controlling the correct and reliable execution of a ... -
A prototype system for context sensitive communication in hospitals based on an Ascom/trixbox experimental platform
(Master thesis; Mastergradsoppgave, 2011-06-01)Hospital's communication infrastructure suffers from different types of common problems. Currently, this infrastructure relies mainly on the use of pagers which are devices particularly interruptive for the daily work of hospital's workers, and moreover they do not support context-awareness communication. Wireless phones are supposed to be a valid alternative to pagers and they can also be used to ... -
Prototyping a Diet Self-management System for People with Diabetes with Cultural Adaptable User Interface Design
(Chapter; Bokkapittel, 2014-08-22)Diet management is a critical part of diabetes selfmanagement. This project developed a working prototype application on Android-based mobile phone called SMART CARB that assists people with diabetes to self-manage their diet. The system particularly focused on monitoring carbohydrate intake in order to control their blood glucose levels. The project was positioned as a research extension to the ... -
ProtoVAE: A Trustworthy Self-Explainable Prototypical Variational Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-15)The need for interpretable models has fostered the development of self-explainable classifiers. Prior approaches are either based on multi-stage optimization schemes, impacting the predictive performance of the model, or produce explanations that are not transparent, trustworthy or do not capture the diversity of the data. To address these shortcomings, we propose ProtoVAE, a variational autoencoder-based ... -
Protracted post-glacial hydrocarbon seepage in the Barents Sea revealed by U–Th dating of seep carbonates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-01)The hydrocarbon seepage chronology during deglaciation across the formerly glaciated Barents Sea was established using uranium-thorium (U–Th) dating of seep carbonates. Seep carbonates were sampled with remotely operated vehicles (ROV) from the seafloor at three active hydrocarbon seeps (water depth 156–383 m), located in the north-west (Storfjordrenna), north-central (Storbanken High), and south-west ... -
Provenance, depositional setting and diagenesis as keys to reservoir quality of the Lower Cretaceous in the SW Barents Sea
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-06)This study examines the role of the depositional environment for the final reservoir quality in four Lower Cretaceous sandstone reservoirs in the southwestern Barents Sea by linking facies to the distribution of primary textures, composition, and diagenetic alteration. Facies analysis reveals slope-to-basin-floor, distal shallow-marine, and deltaic depositional environments. The slope-to-basin-floor ... -
Proximal to distal grain-size distribution of basin-floor lobes: A study from the Battfjellet Formation, Central Tertiary Basin, Svalbard
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-09)The grain-size distribution of sediment particles is an important aspect of the architecture of submarine fans and lobes. It governs depositional sand quality and reflects distribution of particulate organic carbon and pollutants. Documenting the grain-size distribution of these deep-marine sedimentary bodies can also offer us an insight into the flows that deposited them. Submarine lobes ... -
The Pseudoalteromonas multipartite genome: distribution and expression of pangene categories, and a hypothesis for the origin and evolution of the chromid
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-21)Bacterial genomes typically consist of one large chromosome, but can also include secondary replicons. These so-called multipartite genomes are scattered on the bacterial tree of life with the majority of cases belonging to Proteobacteria. Within the class gamma-proteobacteria, multipartite genomes are restricted to the two families <i>Vibrionaceae</i> and <i>Pseudoalteromonadaceae</i>. Whereas the ... -
Psoriasis pathogenesis – Pso p27 constitutes a compact structure forming large aggregates
(Journal article; Tidsskriftartikkel, 2015-07)Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed areas of the skin lesions argue for an immunological disease with a local production of a causal antigen. Pso p27 is a protein generated in mast cells in psoriatic plaques, but ... -
Psykososial beredskap sett i sammenheng med samfunnssikkerhet og beredskapsplanlegging. En dokumentanalyse av veiledere, lovverk og rapporter vedrørende psykososial beredskap
(Master thesis; Mastergradsoppgave, 2017-06-01)Etter 22.juli har det vært et økt fokus på de psykiske effekter av kriser og katastrofer. Psykososial beredskap som ord og fenomen er relativt nytt og har forskjellige betydninger med tanke på hvilken teoretisk retting som beskriver fenomenet. Fenomenet har i liten grad blitt løftet opp mot et samfunnsfaglig aspekt, psykososial beredskapen har blitt brukt som samlebegrep for veldig mange temaer. ... -
Pulsating aurora and cosmic noise absorption associated with growth-phase arcs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-18)The initial stage of a magnetospheric substorm is the growth phase, which typically lasts 1–2 h. During the growth phase, an equatorward moving, east–west extended, optical auroral arc is observed. This is called a growth-phase arc. This work aims to characterize the optical emission and riometer absorption signatures associated with growth-phase arcs of isolated substorms. This is done using ... -
The pulsation modes of the pre-white dwarf PG 1159-035
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)Context. PG 1159-035, a pre-white dwarf with Teff ≃ 140 000 K, is the prototype of both two classes: the PG 1159 spectroscopic class and the DOV pulsating class. Previous studies of PG 1159-035 photometric data obtained with the Whole Earth Telescope (WET) showed a rich frequency spectrum allowing the identification of 122 pulsation modes. Analyzing the periods of pulsation, it is possible to ... -
Pumped Hydropower Conversion and Renewable Hybrid Power Plants at Senja
(Master thesis; Mastergradsoppgave, 2020-09-30)With an increasing demand for power on a global scale, and an increasing interest in renewable energy sources, both solar and wind power is growing fast. Their efficiency is increasing while the prices are decreasing, and the forecasts for these technologies shows a promising future. Along with these intermittent energy sources, storage solutions are also continuously developing, whereas pumped ...
