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dc.contributor.authorOlsen, Elisabeth Klungerbo
dc.contributor.authorHansen, Espen
dc.contributor.authorIsaksson, Johan
dc.contributor.authorAndersen, Jeanette hammer
dc.date.accessioned2014-02-18T13:51:56Z
dc.date.available2014-02-18T13:51:56Z
dc.date.issued2013
dc.description.abstractThree known bromophenols, 2,3-dibromo-4,5-dihydroxybenzylaldehyde (1), 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy 6′-hydroxymethyldiphenylmethane (2) and bis(2, 3-dibromo-4,5-dihydroxylbenzyl) ether (3), and one new one, 5,5″-oxybis(methylene)bis (3-bromo-4-(2′,3′-dibromo-4′,5′-dihydroxylbenzyl)benzene-1,2-diol) (4), were isolated from an extract of the red alga, Vertebrata lanosa. The antioxidant activity of these four bromophenols was examined using one biochemical and two cellular assays: Oxygen Radical Absorbance Capacity (ORAC), Cellular Antioxidant Activity (CAA) and Cellular Lipid Peroxidation Antioxidant Activity (CLPAA) assays. Compound 2 distinguished itself by showing potent activity, having a better antioxidant effect than luteolin in both the CAA and CLPAA assays and of quercetin in the CLPAA assay. Although several bromophenols are known to be potent antioxidants in biochemical assays, this is the first time their cellular antioxidant activity has been demonstrated.en
dc.identifier.citationMarine Drugs 11(2013) s. 2769-2784en
dc.identifier.cristinIDFRIDAID 1060204
dc.identifier.doihttp://dx.doi.org/10.3390/md11082769
dc.identifier.issn1660-3397
dc.identifier.urihttps://hdl.handle.net/10037/5849
dc.identifier.urnURN:NBN:no-uit_munin_5545
dc.language.isoengen
dc.publisherMDPIen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Biochemistry: 476en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Biokjemi: 476en
dc.titleCellular Antioxidant Effect of Four Bromophenols from the Red Algae, Vertebrata lanosaen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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