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dc.contributor.authorStorhaug, Hilde-Merete
dc.contributor.authorNorvik, Jon Viljar
dc.contributor.authorToft, Ingrid
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorZykova, Svetlana
dc.contributor.authorSolbu, Marit Dahl
dc.contributor.authorWhite, Sarah
dc.contributor.authorChadban, S
dc.contributor.authorJenssen, Trond Geir
dc.date.accessioned2014-02-27T07:37:48Z
dc.date.available2014-02-27T07:37:48Z
dc.date.issued2013
dc.description.abstractBackground: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional and non-traditional risk factors for cardiovascular disease included in the model. Methods: A population-based prospective cohort study was performed among 2696 men and 3004 women. Endpoints were all-cause mortality after 15 years, and fatal or non-fatal myocardial infarction (MI) and ischemic stroke after 12 years. Results: 1433 deaths, 659 MIs and 430 ischemic strokes occurred during follow-up. Fully adjusted Cox regression analyses showed that per 1 SD (87 μmol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). HRs and 95% CI for stroke were 1.31, 1.14-1.50 in men, 1.13, 0.94-1.36 in women, and 1.22 (1.09, 1.35) in the overall population. No independent associations were observed with MI. Conclusion: Serum uric acid was associated with all-cause mortality in men and women, even after adjustment for blood pressure, estimated GFR, urinary albumin/creatinine ratio, drug intake and traditional cardiovascular risk factors. After the same adjustments, serum uric acid was associated with 31% increased risk of stroke in men.en
dc.identifier.citationBMC Cardiovascular Disorders (2013), vol. 13:115en
dc.identifier.cristinIDFRIDAID 1088350
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2261-13-115
dc.identifier.issn1471-2261
dc.identifier.urihttps://hdl.handle.net/10037/5877
dc.identifier.urnURN:NBN:no-uit_munin_5575
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en
dc.titleUric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Studyen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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