English
norskBlar i tittel Artikler, rapporter og annet (medisinsk biologi)
Viser treff 288-307 av 1054
-
Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-06) -
Elucidating the small regulatory RNA repertoire of the sea anemone Anemonia viridis based on whole genome and small RNA sequencing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)Cnidarians harbor a variety of small regulatory RNAs that include microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), but detailed information is limited. Here, we report the identification and expression of novel miRNAs and putative piRNAs, as well as their genomic loci, in the symbiotic sea anemone <i>Anemonia viridis</i>. We generated a draft assembly of the <i>A. viridis</i> genome with ... -
Emergence of clonally related multidrug resistant haemophilus influenzae with penicillin-binding protein 3-mediated resistance to extended-spectrum cephalosporins, Norway, 2006 to 2013
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Emergence of vancomycin-resistant enterococci from vancomycin susceptible enterococci in hospitalized patients under antimicrobial therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-19)Objectives: Enterococci are opportunistic pathogens with plastic genomes that evolve, acquire, and transmit antimicrobial-resistant determinants such as vancomycin resistance clusters. While vancomycinresistant enterococci (VRE) have emerged as successful nosocomial pathogens, the mechanism by which vancomycin-susceptible enterococci (VSE) transform to VRE in hospitalized patients remains ... -
EMMA 2-A MAGE-compliant system for the collaborative analysis and integration of microarray data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009) -
En pionerforsker
(Journal article; Tidsskriftartikkel, 2013)Professor Svein Dahl ved Universitetet i Tromsø var en framtredende og nyskapende legemiddelforsker. De metodene han benyttet, brukes den dag i dag av farmasøytisk industri og forskere over hele verden. -
Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL-1RN and the IL-1β monoclonal antibody canakinumab reduce the expansion of leukemic cells, including CD34+ ... -
Endoscopic full-thickness dissection (EFTD) in the rectum: a case series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-28)Background Rectal endoscopic full- thickness dissection (EFTD) using a fexible colonoscope is an alternative to the wellestablished trans-anal endoscopic microsurgery (TEM) and the trans-anal minimally invasive surgery (TAMIS) techniques for resecting dysplastic or malignant rectal lesions. This study evaluated EFTD safety by analyzing outcomes of the frst patients to undergo rectal EFTD at the ... -
Energy expenditure of free-living reindeer estimated by the doubly labelled water method.
(Journal article; Peer reviewed; Tidsskriftartikkel, 2000) -
Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-10)<p><i>Background - </i>Desmoid tumors are intermediary malignant, fibrous lesions occurring in various soft tissues. Surgical treatment is relentlessly challenging because of the propensity for local aggressive behavior and high risk of recurrence. Consequently, a wide range of oncological drugs and radiation therapy are being used; however, outcomes are unpredictable. We investigated whether local ... -
Enterococcal Membrane Vesicles as Vaccine Candidates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-07)Enterococcus faecium is a leading cause of nosocomial infections, particularly in immunocompromised patients. The rise of multidrug-resistant E. faecium, including Vancomycin-Resistant Enterococci (VRE), is a major concern. Vaccines are promising alternatives to antibiotics, but there is currently no vaccine available against enterococci. In a previous study, we identified six protein vaccine ... -
The enterococcus cassette chromosome, a genomic variation enabler in enterococci
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)Enterococcus faecium has a highly variable genome prone to recombination and horizontal gene transfer. Here, we have identified a novel genetic island with an insertion locus and mobilization genes similar to those of staphylococcus cassette chromosome elements SCCmec. This novel element termed the enterococcus cassette chromosome (ECC) element was located in the 3′ region of rlmH and encoded large ... -
Enterococcus faecium produces membrane vesicles containing virulence factors and antimicrobial resistance related proteins
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-30)<i>Enterococcus faecium</i> is a commensal but also a bacteremia causing pathogen, which is inherently resistant to several antimicrobials and has a great ability to acquire new traits. Bacterial membrane vesicles (MVs) are increasingly recognized as a mode of cell-free communication and a way to deliver virulence factors and/or antimicrobial resistance determinants. These features make MVs interesting ... -
Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)<i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> ... -
Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Marine mammal Brucella spp. have been isolated from pinnipeds (B. pinnipedialis) and cetaceans (B. ceti) from around the world. Although the zoonotic potential of marine mammal brucellae is largely unknown, reports of human disease exist. There are few studies of the mechanisms of bacterial intracellular invasion and multiplication involving the marine mammal Brucella spp. We examined the infective ... -
Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-15)<p><i>Background - </i>The 13-valent Pneumococcal Conjugate Vaccine (PCV-13) was introduced in the National Immunization Programme (NIP) schedule in Russia in March 2014. Previously, the 7-valent Pneumococcal Conjugate Vaccine (PCV-7) was marketed in Russia in 2009 but has never been offered for mass vaccination. A carriage study was performed among children in Arkhangelsk in 2006. The objective was ... -
Epigenomic and transcriptomic approaches in the post-genomic era: Path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-29)Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully ... -
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: Neuroblastoma (NB) tumours are commonly divided into three cytogenetic subgroups. However, by unsupervised principal components analysis of gene expression profiles we recently identified four distinct subgroups, r1-r4. In the current study we characterized these different subgroups in more detail, with a specific focus on the fourth divergent tumour subgroup (r4). Methods: Expression ... -
Erfaringer med økonomiske støtteordninger for tannbehandling hos personer som er behandlet for hode-halskreft
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11)Medlemmer i Munn- og halskreftforeningen mottok et spørreskjema for å kartlegge erfaringer med økonomiske refusjonsordninger for tannbehandling og kostnader til tannbehandling hos personer som er behandlet for hode-halskreft i Norge. I tillegg kartla vi utviklingen i Folketrygdens honorartakster for tannbehandling i perioden 2015-2020, og sammenlignet honorartakstene for 2021 med takstene for ... -
ESC working group on cellular biology of the heart: Position paper for Cardiovascular Research: Tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-17)Morbidity and mortality from ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and are increasing worldwide. Patients with IHD or HF might benefit from novel therapeutic strategies, such as cellbased therapies. We recently discussed the therapeutic potential of cell-based therapies and provided recommendations on how to improve the therapeutic translation of these ...
