Blar i tittel Artikler, rapporter og annet (medisinsk biologi)
Viser treff 521-540 av 1054
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Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-22)The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fungi, or both to differentiate the causal role of fungi on microbiome assembly, immune development, ... -
Intra-cellular to inter-organ mitochondrial communication in striated muscle in health and disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)Mitochondria sense both biochemical and energetic input in addition to communicating signals regarding the energetic state of the cell. Increasingly, these signaling organelles are recognized as key for regulating different cell functions. This review summarizes recent advances in mitochondrial communication in striated muscle, with specific focus on the processes by which mitochondria communicate ... -
Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-29)Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to contribute to post-ischemic loss of contractility, little is known about intracellular MMP-2 activity ... -
Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)Infections with OXA-244-carbapenemase-producing Escherichia coli with sequence type (ST)38 have recently increased in Europe. Due to its low-level activity against carbapenems, OXA-244 can be difficult to detect. Previous assessments have not revealed a clear source and route of transmission for OXA-244-producing E. coli, but there are indications of non-healthcare related sources and community ... -
Introduktion: Arbejde – sundhed og sygdom
(Journal article; Tidsskriftartikkel, 2012)I dette temanummer kigger vi nærmere på forholdet mellem arbejde, sundhed og sygdom. -
Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-10)Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGE). Here, we investigate this mobilome in successful hospital associated genetic lineages, E. faecium sequence type (ST)17 (n=10) and ... -
An investigation of multidisciplinary complex health care interventions - steps towards an integrative treatment model in the rehabilitation of People with Multiple Sclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)The Danish Multiple Sclerosis Society initiated a large-scale bridge building and integrative treatment project to take place from 2004–2010 at a specialized Multiple Sclerosis (MS) hospital. In this project, a team of five conventional health care practitioners and five alternative practitioners was set up to work together in developing and offering individualized treatments to 200 people with MS. ... -
Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-25)Cancer-associated fibroblasts (CAFs) are abundantly present in solid tumors and affect tumorigenesis and therapeutic responses. In the context of clinical radiotherapy, the impact of irradiated CAFs to treatment outcomes is largely unexplored. Aiming at improving radiotherapy efficacy, we have here explored the effect of radiation on the inherent pro-tumorigenic capacity of CAFs in animals. Ionizing ... -
Is a high level of general practitioner consultations associated with low outpatients specialist clinic use? A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Objective: To examine if increased general practice activity is associated with lower outpatient specialist clinic use. Design: Cross-sectional population based study. Setting: All 430 Norwegian municipalities in 2009. Participants: All Norwegians aged ≥65 years (n=721 915; 56% women—15% of the total population). Main outcome measure: Specialised care outpatient clinic consultations per 1000 ... -
Isolated perfused working hearts provide valuable additional information during phenotypic assessment of the diabetic mouse heart
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)Although murine models for studying the development of cardiac dysfunction in diabetes mellitus are well established, their reported cardiac phenotypes vary. These reported divergences may, in addition to the severity of different models, also be linked to the methods used for cardiac functional assessment. In the present study, we examined the functional changes using conventional transthoracic ... -
Ixodes ricinus and Borrelia prevalence at the Arctic Circle in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-18)The distribution limit of Ixodes ricinus ticks in northwestern Europe (Brønnøy, Norway, 1◦ south of the Arctic Circle), has been known since the 1930s. To reconfirm this finding and extend studies in the areas adjacent to the Arctic Circle (66◦33 N), ticks were collected from dogs and cats in 8 districts in northern Norway from 64◦56 N to 68◦48 N. We detected 549 I. ricinus, 244 (44%) of them ... -
Iyengar Yoga for Distressed Women: A 3-Armed Randomized Controlled Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Distress is an increasing public health problem. We aimed to investigate the effects of an Iyengar yoga program on perceived stress and psychological outcomes in distressed women and evaluated a potential dose-effect relationship. Seventy-two female distressed subjects were included into a 3-armed randomized controlled trial and allocated to yoga group 1 (n = 24) with twelve 90 min sessions over 3 ... -
Kartlegging av miljøgifter i sjøfuglegg fra Sklinna og Røst
(Research report; Forskningsrapport, 2014)I dette kartleggingsprosjektet ble analysert konsentrasjonene til en lang rekke uorganiske og organiske miljøgifter, som metaller, organotinn, polysykliske aromatiske hydrokarboner, polyklorerte bifenyler og metabolitter, klorerte parafiner, klororganiske pesticider og andre pesticider, per- og polyfluoralkylstoffer, deklorane pluss, oktaklorostyren, organofosfor flammehemmere, bromerte flammehemmere, ... -
Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate immunity is still unclear. Here we show that Drosophila Kenny, the homolog of mammalian IKKγ, is a selective autophagy receptor that mediates the degradation of the IκB kinase ... -
KI and WU Polyomavirus in Respiratory Samples of SARS-CoV-2 Infected Patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 ... -
Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-16)Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN). Renal TLS was characterized in lupus-prone New Zealand black × New Zealand white F1 mice analyzing cell composition and vessel formation. RNA sequencing was performed on transcriptomes isolated from lymph nodes, macrodissected TLS ... -
Kliniske studier av av yrkesbetinget løsemiddeleksponerte. Et systematisk litteratursøk
(Research report; Forskningsrapport, 2009)I Norge er det enighet om de overordnede kriteriene for å gi diagnosen løsemiddelskade. Likevel er det ikke utviklet en enhetlig og detaljert modell for utredning av slik skade. Nasjonalt kunnskapssenter for helsetjenesten har i samarbeid med de norske utredningsmiljøene for løsemiddelskade gjennomført et litteratursøk etter kliniske studier av personer med langvarig yrkesbetinget løsemiddeleksponering. ... -
Knowing patients as persons: Senior and Junior GPs explore a professional resource
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-29)As part of a research project exploring inter-professional communication in Norwegian healthcare, junior and senior general practitioners (GPs) participated in focus group interviews regarding the medical relevance of acquiring and sharing knowledge about their patients as persons. The transcripts were interpreted using phenomenological- hermeneutical and discourse analysis. Both GP groups expressed ... -
Kvalitetskontroll av serologiske analyser. Virologisk-serologisk strategimøte 1. november 2001
(Research report; Forskningsrapport, 2001) -
Kvalitetssikring av genteknologiske metoder
(Research report; Forskningsrapport, 2018-09)Kvalitetskontroll av infeksjonsserologiske metoder var tema for strategimøtet i 2016 og det er dermed naturlig å følge opp med kvalitetssikring av molekylærgenetiske metoder i år. På møtet i fjor ble det gitt detaljerte anbefalinger om validering/verifisering, internkontroller, usikkerhetsbedømmelse, gråsoner og tolkning. Genteknologiske metoder skiller seg betydelig fra serologi, og kvalitetssikr ...