Artikler, rapporter og annet (medisinsk biologi): Nye registreringer

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    • Registration rate in the Norwegian Cruciate Ligament Register Large-volume hospitals perform better 

      Ytterstad, Karianne; Granan, Lars-Petter; Ytterstad, Børge; Steindal, Kjersti; Fjeldsgaard, Knut; Furnes, Ove; Engebretsen, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Background and purpose: The Norwegian Cruciate Ligament Register (NCLR) was founded in 2004. The purpose of the NCLR is to provide representative and reliable data for future research. In this study we evaluated the development of the registration rate in the NCLR. Methods: The Norwegian Patient Register (NPR) and the electronic patient charts (EPCs) were used as reference data for public and ...

    • High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator 

      Sørbye, Sveinung Wergeland; Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Dønnem, Tom; Smeland, Eivind; Al-Shibli, Khalid Ibrahim; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel, 2012)
      The immune status is important in cancer patients. Tissue microarrays from 249 patients with soft tissue sarcomas were constructed. Immunohistochemistry was used to evaluate the CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in tumors. High density of CD20+ lymphocytes is an independent positive prognostic indicator for these patients.

    • Clinical Gaze in Risk-Factor Haze: Swedish GPs' Perceptions of Prescribing Cardiovascular Preventive Drugs 

      Hultberg, Josabeth; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      To explore general practitioners’ (GPs’) descriptions of their thoughts and action when prescribing cardiovascular preventive drugs. Methods. Qualitative content analysis of transcribed group interviews with 14 participants from two primary health care centres in the southeast of Sweden. Results. GPs’ prescribing of cardiovascular preventive drugs, from their own descriptions, involved “the patient ...

    • The benefit of a mechanical needle stimulation pad in patients with chronic neck and lower back pain: two randomized controlled pilot studies 

      Hohmann, Claudia; Ullrich, Isabella; Lauche, Romy; Choi, Kyung-Eun; Lüdtke, Rainer; Rolke, Rainer; Cramer, Holger; Saha, Felix Joyonto; Rampp, Thomas; Michalsen, Andreas; Langhorst, Jost; Dobos, Gustav J.; Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The objective was to investigate whether a treatment with a needle stimulation pad (NSP) changes perceived pain and/or sensory thresholds in patients with chronic neck (NP) and lower back pain (BP). Methods. 40 patients with chronic NP and 42 patients with chronic BP were equally randomized to either treatment or waiting list control group. The treatment group selfadministered a NSP over a period ...

    • Social Inequalities and Mortality in Europe - Results from a Large Multi-National Cohort 

      Gallo, Valentina; Mackenbach, Johan P.; Ezzati, Majid; Menvielle, Gwenn; Kunst, Anton E.; Rohrmann, Sabine; Kaaks, Rudolf; Teucher, Birgit; Boeing, Heiner; Bergmann, Manuela M.; Tjønneland, Anne; Dalton, Susanne O.; Overvad, Kim; Redondo, Maria Luisa; Agudo, Antonio; Daponte, Antonio; Arriola, Larraitz; Navarro, Camen; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Wareham, Nick; Key, Tim; Naska, Androniki; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Masala, Giovanna; Panico, Salvatore; Contiero, Paolo; Tumino, Rosario; Bueno-de-Mesquita, H. Bas; Siersema, Peter D.; Peeters, Petra P. H.; Zackrisson, Sophia; Almquist, Martin; Eriksson, Sture; Hallmans, Göran; Skeie, Guri; Braaten, Tonje; Lund, Eiliv; Illner, Anne-Kathrin; Mouw, Traci; Riboli, Elio; Vineis, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and ...

    • Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e 

      Thiyagarajan, Dhivya; Fismen, Silje; Seredkina, Natalya; Jacobsen, Søren; Elung-Jensen, Thomas; Kamper, Anne-Lise; Fenton, Christopher Graham; Rekvig, Ole Petter; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Recent studies demonstrate that transformation of mild lupus nephritis into end-stage disease is imposed by silencing of renal DNaseI gene expression in (NZBxNZW)F1 mice. Down-regulation of DNaseI results in reduced chromatin fragmentation, and in deposition of extracellular chromatin-IgG complexes in glomerular basement membranes in individuals that produce IgG anti-chromatin antibodies. The main ...

    • Sources of pre-analytical variations in yield of DNA extracted from blood samples: analysis of 50,000 DNA samples in EPIC 

      Caboux, Elodie; Lallemand, Christophe; Ferro, Gilles; Hemon, Bertrand; Mendy, Maimuna; Biessy, Carine; Sims, Matt; Wareham, Nicholas; Britten, Abigail; Boland, Anne; Hutchinson, Amy; Siddiq, Afshan; Vineis, Paolo; Riboli, Elio; Romieu, Isabelle; Rinaldi, Sabina; Gunter, Mark J.; Peeters, Petra H.M.; van der Schouw, Yvonne T.; Travis, Ruth C.; Bueno-De-Mesquita, H. Bas; Canzian, Federico; Sanchez, Maria-José; Skeie, Guri; Olsen, Karina Standahl; Lund, Eiliv; Bilbao, Roberto; Sala, Núria; Barricarte, Aurelio; Palli, Domenico; Navarro, Carmen; Panico, Salvatore; Redondo, Maria Luisa; Polidoro, Silvia; Dossus, Laure; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Lagiou, Pagona; Boeing, Heiner; Fisher, Eva; Tumino, Rosario; Agnoli, Claudia; Hainaut, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The European Prospective Investigation into Cancer and nutrition (EPIC) is a long-term, multi-centric prospective study in Europe investigating the relationships between cancer and nutrition. This study has served as a basis for a number of Genome-Wide Association Studies (GWAS) and other types of genetic analyses. Over a period of 5 years, 52,256 EPIC DNA samples have been extracted using an automated ...

    • Birth Weight, Breast Cancer and the Potential Mediating Hormonal Environment 

      Bukowski, Radek; Chlebowski, Rowan; Thune, Inger; Furberg, Anne-Sofie; Hankins, Gary; Malone, Fergal; D'Alton, Mary (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Previous studies have shown that woman’s risk of breast cancer in later life is associated with her infants birth weights. The objective of this study was to determine if this association is independent of breast cancer risk factors, mother’s own birth weight and to evaluate association between infants birth weight and hormonal environment during pregnancy. Independent association would have ...

    • Clinical influences on antibiotic prescribing decisions for lower respiratory tract infection: a nine country qualitative study of variation in care. 

      Brookes-Howell, Lucy; Hood, Kerenza; Cooper, Lucy; Coenen, Samuel; Little, Paul; Verheij, Theo; Godycki-Cwirko, Maciek; Melbye, Hasse; Krawzyk, Jarek; Borras-Santos, A; Jakobsen, Kristin Alise; Worby, P; Goossens, Herman; Butler, Christopher C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      There is variation in antibiotic prescribing for lower respiratory tract infections (LRTI) in primary care that does not benefit patients. This study aims to investigate clinicians' accounts of clinical influences on antibiotic prescribing decisions for LRTI to better understand variation and identify opportunities for improvement. Multi country qualitative interview study. Semi-structured interviews ...

    • Understanding variation in primary medical care: a nine-country qualitative study of clinicians' accounts of the non-clinical factors that shape antibiotic prescribing decisions for lower respiratory tract infection. 

      Brookes-Howell, Lucy; Hood, Kerenza; Cooper, Lucy; Little, Paul; Verheij, Theo; Coenen, Samuel; Godycki-Cwirko, Maciek; Melbye, Hasse; Borras-Santos, A; Worby, P; Jakobsen, Kristin Alise; Goossens, Herman; Butler, Christopher C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      There is a wide variation between European countries in antibiotic prescribing for patients in primary care with lower respiratory tract infection (LRTI) that is not explained by case mix and clinical factors alone. Variation in antibiotic prescribing that is not warranted by differences in illness and clinical presentation may increase selection of resistant organisms, contributing to the problem ...

    • Multiple miscarriages are associated with the risk of ovarian cancer: results from the European prospective investigation into cancer and nutrition 

      Braem, Marieke G.M.; Onland-Moret, N. Charlotte; Schouten, Leo J; Kruitwagen, Roy F.P.M.; Lukanova, Annekatrin; Allen, Naomi E.; Wark, Petra A.; Tjønneland, Anne; Hansen, Louise; Braüner, Christina Marie; Overvad, Kim; Clavel-Chapelon, Françoise; Chabbert-Buffet, Nathalie; Teucher, Birgit; Floegel, Anna; Boeing, Heiner; Trichopoulou, Antonia; Adarakis, George; Plada, Maria; Rinaldi, Sabina; Fedirko, Veronika; Romieu, Isabelle; Pala, Valeria; Galasso, Rocco; Sacerdote, Carlotta; Palli, Domenico; Tumino, Rosario; Bueno-De-Mesquita, H. Bas; Gram, Inger Torhild; Gavrilyuk, Oxana; Lund, Eiliv; Sanchez, Maria-José; Bonet, Catalina; Chirlaque, María Dolores; Larranaga, Nerea; Gurrea, Aurelio Barricarte; Quirós, José R.; Idahl, Annika; Ohlson, Nina; Lundin, Eva; Jirström, Karin; Butt, Salma; Tsilidis, Konstantinos K.; Khaw, Kay-Tee; Wareham, Nick; Riboli, Elio; Kaaks, Rudolf; Peeters, Petra H.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      While the risk of ovarian cancer clearly reduces with each full-term pregnancy, the effect of incomplete pregnancies is unclear. We investigated whether incomplete pregnancies (miscarriages and induced abortions) are associated with risk of epithelial ovarian cancer. This observational study was carried out in female participants of the European Prospective Investigation into Cancer and Nutrition ...

    • Retinal Vessel Width Measurement at Branchings Using an Improved Electric Field Theory-Based Graph Approach 

      Xu, Xiayu; Reinhardt, Joseph M.; Hu, Qiao; Bakall, Benjamin; Tlucek, Paul S.; Bertelsen, Geir; Abràmoff, Michael D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The retinal vessel width relationship at vessel branch points in fundus images is an important biomarker of retinal and systemic disease. We propose a fully automatic method to measure the vessel widths at branch points in fundus images. The method is a graph-based method, in which a graph construction method based on electric field theory is applied which specifically deals with complex branching ...

    • DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription 

      Sancho, Ana; Duran, Jordi; Garcia-Espana, Antonio; Mauvezin, Caroline; Alemu, Endalkachew Ashenafi; Lamark, Trond; Macias, Maria J.; DeSalle, Rob; Royo, Miriam; Sala, David; Chicote, Javier U.; Palacin, Manuel; Johansen, Terje; Zorzano, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not been identified. Here we have performed structure/function analyses of DOR guided by identification of conserved regions in the DOR gene family by phylogenetic reconstructions. We show that DOR is present in ...

    • Serum apolipoproteins in relation to intakes of fish in population of Arkhangelsk County 

      Petrenya, Natalia Nikolaevna; Brustad, Magritt; Cooper, Marie; Dobrodeeva, Lilya; Bichkaeva, Fatima; Lutfalieva, Gulnara; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Diets rich in omega-3 fatty acids and low in saturated fat were found beneficially associated with blood lipids and cardio-vascular health. Lean reindeer meet and local cold water white-fish species high in omega-3 are among the main sources of nutrients in the rural area of the Nenets Autonomous Okrug (NAO) in Russia and are not normally consumed by the urban population from the same region. The ...

    • Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Murphy, Neil; Norat, Teresa; Ferrari, Pietro; Jenab, Mazda; Bueno-de-Mesquita, H. Bas; Skeie, Guri; Dahm, Christina C.; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Racine, Antoine; Kaaks, Rudolf; Teucher, Birgit; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Lagiou, Pagona; Palli, Domenico; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Siersema, Peter D.; van Duijnhoven, Fränzel J.B.; Peeters, Petra H M; Hjartåker, Anette; Engeset, Dagrun; Gonzalez, Carlos A.; Sánchez, Maria-José; Dorronsoro, Miren; Navarro, Camen; Ardanaz, Eva; Quirós, José R.; Sonestedt, Emily; Ericson, Ulrika; Nilsson, Lena; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J.; Crowe, Francesca L.; Fedirko, Veronika; Wark, Petra A.; Chuang, Shu-Chun; Riboli, Eilo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. After a mean ...

    • Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mortality: A Large Pooled Cohort Analysis 

      Moore, Steven C.; Patel, Alpa; Matthews, Charles E.; de Gonzalez, Amy Berrington; Park, Yikyung; Katki, Hormuzd A.; Linet, Martha S.; Weiderpass, Elisabete; Visvanathan, Kala; Helzlsouer, Kathy J; Thun, Michael; Gapstur, Susan M; Hartge, Patricia; Lee, I-Min (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Leisure time physical activity reduces the risk of premature mortality, but the years of life expectancy gained at different levels remains unclear. Our objective was to determine the years of life gained after age 40 associated with various levels of physical activity, both overall and according to body mass index (BMI) groups, in a large pooled analysis. We examined the association of leisure ...

    • Iyengar Yoga for Distressed Women: A 3-Armed Randomized Controlled Trial 

      Michalsen, Andreas; Jeitler, Michael; Brunnhuber, Stefan; Lüdtke, Rainer; Büssing, Arndt; Musial, Frauke; Dobos, Gustav; Kessler, Christian (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Distress is an increasing public health problem. We aimed to investigate the effects of an Iyengar yoga program on perceived stress and psychological outcomes in distressed women and evaluated a potential dose-effect relationship. Seventy-two female distressed subjects were included into a 3-armed randomized controlled trial and allocated to yoga group 1 (n = 24) with twelve 90 min sessions over 3 ...

    • Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study 

      May, Anne M.; Romaguera, Dora; Travier, Noémie; Ekelund, Ulf; Bergmann, Manuela M.; Kaaks, Rudolf; Teucher, Birgit; Steffen, Annika; Boeing, Heiner; Halkjaer, Jytte; Tjonneland, Anne; Jakobsen, Marianne Uhre; Overvad, Kim; Dartois, Laureen; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Quirós, J. Ramón; Agudo, Antonio; Gonzalez, Carlos; Sanchez, Maria-José; Amiano, Pilar; Huerta, José-Maria; Ardanaz, Eva; Wareham, Nicholas J.; Crowe, Francesca L.; Naska, Androniki; Orfanos, Philippos; Trichopoulou, Antonia; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Verschuren, Monique; Drake, Isabel; Sonestedt, Emily; Braaten, Tonje; Rinaldi, Sabina; Romieu, Isabelle; Slimani, Nadia; Norat, Teresa; Riboli, Eilo; Peeters, Petra H.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The evidence that individual dietary and lifestyle factors influence a person’s weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference. We used data of the prospective EPIC-PANACEA study. ...

    • Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy 

      Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins. Proteins that are damaged beyond repair are degraded ...

    • Do Malawian women critically assess the quality of care? A qualitative study on women’s perceptions of perinatal care at a district hospital in Malawi 

      Kumbani, Lily C; Chirwa, Ellen; Malata, Address; Odland, Jon Øyvind; Bjune, Gunnar Aksel (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Malawi has a high perinatal mortality rate of 40 deaths per 1,000 births. To promote neonatal health, the Government of Malawi has identified essential health care packages for improving maternal and neonatal health in health care facilities. However, regardless of the availability of health services, women’s perceptions of the care is important as it influences whether the women will or will not ...