Now showing items 1009-1028 of 1796

    • M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis 

      Brix, Ninna; Glerup, Mia; Thiel, Steffen; Mistegaard, Clara Elbæk; Skals, Regitze Gyldenholm; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan Mary; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Albertsen, Birgitte Klug; Herlin, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-22)
      Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague. The primary aim was to examine the use of lectin complement pathway proteins as markers to differentiate ALLarthropathy from JIA. The secondary aims were ...
    • Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

      Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)
      <i>Objective</i> - We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury.<br><br> <i>Study Design and Setting</i> - We performed logistic regression (LR), lasso regression, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, <i>n</i> = 11,022). ML algorithms ...
    • Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study 

      Ihlen, Espen Alexander F.; Støen, Ragnhild; Boswell, Lynn; de-Regnier, Raye-Ann; Fjørtoft, Toril Larsson; Gaebler-Spira, Deborah; Labori, Cathrine; Loennecken, Marianne; Msall, Michael; Møinichen, Unn Inger; Peyton, Colleen; Schreiber, Michael; Silberg, Inger Elisabeth; Songstad, Nils Thomas; Vågen, Randi; Øberg, Gunn Kristin; Adde, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      <i>Background</i>: Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the Computer-based Infant Movement Assessment (CIMA) model, for clinically feasible early CP prediction based on infant video recordings.<p><p> <i>Methods</i>: The CIMA model was ...
    • Machine-learning-derived heart and brain age are independently associated with cognition 

      Iakunchykova, Olena; Schirmer, Henrik; Vangberg, Torgil Riise; Wang, Yunpeng; Benavente, Ernest D.; van Es, René; van de Leur, Rutger R.; Lindekleiv, Haakon; Attia, Zachi I.; Lopez-Jimenez, Francisco; Leon, David A.; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-31)
      Background and purpose - A heart age biomarker has been developed using deep neural networks applied to electrocardiograms. Whether this biomarker is associated with cognitive function was investigated.<p> <p>Methods - Using 12-lead electrocardiograms, heart age was estimated for a population-based sample (N = 7779, age 40–85 years, 45.3% men). Associations between heart delta age (HDA) and ...
    • Macrophage stimulating agent soluble yeast β-1,3/1,6-glucan as a topical treatment of diabetic foot and leg ulcers: A randomized, double blind, placebo-controlled phase II study 

      Zykova, Svetlana; Balandina, K; Vorokhobina, NV; Kuznetsova, A; Engstad, R; Zykova, TA (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study 

      von Hanno, Therese; Hareide, Live Lund; Småbrekke, Lars; Morseth, Bente; Sneve, Monica; Erke, Maja Gran; Mathiesen, Ellisiv B.; Bertelsen, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-12)
      PURPOSE. The purpose of this study was to investigate associations between cardiovascular risk factors and the thickness of retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and outer retina layers (ORL).<p> <p>METHODS. In this population-based study, we included participants from the Tromsø Study: Tromsø6 (2007 to 2008) and Tromsø7 (2015 to 2016). Persons with ...
    • Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) 

      Hanno, Therese von; Lade, Anette Caroline; Mathiesen, Ellisiv B.; Peto, Tunde; Njølstad, Inger; Bertelsen, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-18)
      Purpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction (SER) within 6 dioptres. Retinal thickness was measured with optical coherence ...
    • Magnetic resonance imaging for non-invasive measurement of plastic ingestion in marine wildlife 

      Anderssen, Kathryn Elizabeth; Gabrielsen, Geir W.; Kranz, Mathias; Collard, France (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Monitoring plastic ingestion by marine wildlife is important for both characterizing the extent of plastic pollution in the environment and understanding its effect on species and ecosystems. Current methods to detect plastic in the digestive system of animals are slow and invasive, such that the number of animals that can be screened is limited. In this article, magnetic resonance imaging (MRI) ...
    • Magnetic resonance volumetry: prediction of subjective memory complaints and mild cognitive impairment, and associations with genetic and cardiovascular risk factors 

      Rogne, Sigbjørn Olav; Vangberg, Torgil Riise; Eldevik, Odd Petter; Wikran, Gry Charlotte; Mathiesen, Ellisiv B.; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
      <i>Background/Aims</i>: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer’s disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC and MCI from controls, and if probable parental late-onset Alzheimer’s disease (LOAD), apolipoprotein E ε4 genotype, total plasma homocysteine, ...
    • Maintaining intravenous volume mitigates hypothermia-induced myocardial dysfunction and accumulation of intracellular Ca2+ 

      Nilsen, Jan Harald; Schanche, Torstein; Kondratiev, Timofei V.; Hevrøy, Olav; Tveita, Torkjel; Sieck, Gary C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-17)
      Previous research exploring pathophysiological mechanisms underlying circulatory collapse after rewarming victims of severe accidental hypothermia has documented post-hypothermic cardiac dysfunction and hypothermia-induced elevation of intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) in myocardial cells. The aim of the present study was to examine if maintaining euvolaemia ...
    • Major incident preparedness and on-site work among Norwegian rescue personnel - a cross-sectional study. 

      Fattah, Sabina; Krüger, Andreas J.; Andersen, Jan Einar; vigerust, trond; Rehn, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      A major incident has occurred when the number of live casualties, severity, type of incident or location requires extraordinary resources. Major incident management is interdisciplinary and involves triage, treatment and transport of patients. We aimed to investigate experiences within major incident preparedness and management among Norwegian rescue workers. A questionnaire was answered by 918 ...
    • Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery 

      Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-15)
      Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of TMAO formation from carnitine is via the microbiota-dependent intermediate g-butyrobetaine (gBB). Elevated TMAO levels are associated with cardiovascular disease (CVD), but little ...
    • Making wise decisions for completion thyroidectomies 

      Brun, Vegard Heimly; Brauckhoff, Katrin (Journal article; Tidsskriftartikkel, 2022-11-25)
      <p>Unilateral differentiated thyroid cancer (DTC) <4 cm can be treated with thyroid lobectomy or total thyroidectomy (TT), depending on the presence of high-risk features. Information about some of these features, such as micrometastasis in lymph nodes or microscopic extrathyroidal extension (ETE), are usually incidental findings that only become available after histological assessment from the first ...
    • Mammographic screening in Sami speaking municipalities and a control group. Are early outcome measures influenced by ethnicity? 

      Norum, Jan; Hofvind, Solveig; Nieder, Carsten; Schnell, Edrun Andrea; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-04-16)
      Objectives. Female citizens of Sami (the indigenous people of Norway) municipalities in northern Norway have a low risk of breast cancer. The objective of this study was to describe the attendance rate and outcome of the Norwegian Breast Cancer Screening Program (NBCSP) in the Sami-speaking municipalities and a control group.<p> <p>Study design. A retrospective registry-based study.<p> <p>Methods. ...
    • Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease 

      den Exter, Paul L.; Woller, Scott C.; Robert-Ebadi, Helia; Masias, Camila; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John Bjarne; Geersing, Geert-Jan; Siegal, Deborah M.; de Wit, Kerstin; Klok, Frederikus A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-20)
      Patients with acute venous thromboembolism (VTE) require anticoagulant therapy to prevent recurrent VTE and death, which exposes them to an inherent increased risk of bleeding. Identification of patients at high risk of bleeding, and mitigating this risk, is an essential component of the immediate and long-term therapeutic management of VTE. The bleeding risk can be estimated by either implicit ...
    • Management of Orofacial Manifestations of Juvenile Idiopathic Arthritis: Interdisciplinary Consensus-Based Recommendations 

      Stoustrup, Peter; Resnick, Cory M.; Abramowicz, Shelly; Pedersen, Thomas K.; Michelotti, Ambra; Küseler, Annelise; Koos, Bernd; Verna, Carlalberta; Nordal, Ellen Berit; Granquist, Eric J.; Halbig, Josefine Mareile; Kristensen, Kasper Dahl; Kaban, Leonard B.; Arvidsson, Linda Zamoline; Spiegel, Lynn; Stoll, Matthew L.; Lerman, Melissa A.; Glerup, Mia; Defabianis, Patrizia; Frid, Paula Hanna Therese; Alstergren, Per; Cron, Randy Q.; Ringold, Sarah; Nørholt, Sven Erik; Peltomaki, Timo; Larheim, Tore Arne; Herlin, Troels; Peacock, Zachary S.; Kellenberger, Christian J.; Twilt, Marinka (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Involvement of the temporomandibular joint (TMJ) is common in juvenile idiopathic arthritis (JIA). TMJ arthritis can lead to orofacial symptoms, orofacial dysfunction, and dentofacial deformity with negative impact on quality of life. Management involves interdisciplinary collaboration. No current recommendations exist to guide clinical management. We undertook this study to develop consensus-based ...
    • Management of patients with acute ST-segment elevation myocardial infarction in Russian hospitals adheres to international guidelines 

      Kontsevaya, Anna; Bates, Katie; Schirmer, Henrik; Bobrova, Natalia; Leon, David A.; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
      <i>Objective</i> - Russia has one of the highest cardiovascular mortality rates. Modernisation of the Russian health system has been accompanied by a substantial increase in uptake of percutaneous coronary intervention (PCI), which substantially reduces the risk of mortality in patients with acute ST-elevation myocardial infarction (STEMI). This paper aims to describe contemporary Hospital treatment ...
    • Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous 

      Nieder, Carsten; Guckenberger, Matthias; Gaspar, Laurie E.; Rusthoven, Chad G.; De Ruysscher, Dirk; Sahgal, Arjun; Nguyen, Timothy; Grosu, Anca L.; Mehta, Minesh P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)
      <p><i>Background - </i>Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ ...
    • Management of patients with metastatic prostate cancer (mPC) in a rural part of North Norway with a scattered population: does living near the department of oncology translate into a different pattern of care and survival? 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin; Norum, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
      The goal of the Norwegian Ministry of Health and Care Services is to offer an equal health-care service with the same outcomes wherever people are living within the country. The aim of this study was to evaluate whether this was true for patients diagnosed with metastatic prostate cancer (mPC) and living in Nordland County, a region with a challenging geography and climate and having, several small ...
    • Management of patients with metastatic renal cell cancer and bone metastases 

      Nieder, Carsten; Dalhaug, Astrid; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-28)
      Background/Aim: Previous research has suggested that patients with metastatic renal cell cancer (mRCC) and bone metastases have a poorer prognosis compared to their counterparts with no skeletal involvement. Therefore, we analyzed the management and outcomes of such patients in our center. Patients and Methods: We performed a retrospective study of 35 consecutive patients who received systemic ...