Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer? 

      Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
      The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...

    • Direct angiography demonstrates equal 8-12 years patency rates of radial artery and saphenous vein grafts 

      Bahar, Ramez; Dahl-Eriksen, Øystein; Busund, Rolf; Dahl, Per Erling; Hermansen, Stig Eggen; Iqbal, Amjid; Mannsverk, Jan; Myrmel, Truls; Steigen, Terje; Trovik, Thor; Sørlie, Dag Glen; Bartnes, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      Objectives: The benefits of coronary artery bypass surgery depend on lasting graft patency. To aid rational graft selection, the relative long-term merits of radial artery and saphenous vein grafts need to be determined by a gold standard method and with minimal clinically driven selection bias. Methods: The patency rates of various conduits were determined by direct angiography in 76 patients from ...

    • Discovering the structure and organization of a free Cantonese emotion-label word association graph to understand mental lexicons of emotions 

      Wong, Ting Yat; Fang, Zhiqian; Yu, Yat To; Cheung, Charlton; Hui, Christy L. M.; Elvevåg, Brita; De Deyne, Simon; Sham, Pak Chung; Chen, Eric Y. H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-15)
      Emotions are not necessarily universal across different languages and cultures. Mental lexicons of emotions depend strongly on contextual factors, such as language and culture. The Chinese language has unique linguistic properties that are different from other languages. As a main variant of Chinese, Cantonese has some emotional expressions that are only used by Cantonese speakers. Previous work on ...

    • Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

      Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
      <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...

    • Disease-specific outcomes of Radical Prostatectomies in Northern Norway; A case for the impact of perineural infiltration and postoperative PSA-doubling time 

      Andersen, Sigve; Richardsen, Elin; Nordby, Yngve; Ness, Nora; Størkersen, Øystein; Al-Shibli, Khalid; Dønnem, Tom; Bertilsson, Helena; Busund, Lill-Tove; Angelsen, Anders; Bremnes, Roy M. (Tidsskriftartikkel; Journal article; Peer reviewed, 2014)
      Background Prostate cancer is the most common male malignancy and a mayor cause of mortality in the western world. The impact of clinicopathological variables on disease related outcomes have mainly been reported from a few large US series, most of them not reporting on perineural infiltration. We therefore wanted to investigate relevant cancer outcomes in patients undergoing radical prostatectomy ...

    • Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World: Systematic Review and Meta-Analysis of 47 Observational Studies 

      Solmi, Marco; Fiedorowicz, Jess; Poddighe, Laura; Delogu, Marco; Høye, Anne; Miola, Alessandro; Heiberg, Ina Heidi; Stubbs, Brendon; Smith, Lee; Larsson, Henrik; Attar, Rubina; Nielsen, René E; Cortese, Samuele; Shin, Jae Il; Firth, Joseph; Fusar-Poli, Paolo; Yatham, Lakshmi N; Carvalho, Andre F; Castle, David J; Correll, Christoph U; Seeman, Mary V (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)
      <p><i>Objective:</i> This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. <p><i>Methods:</i> The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and ...

    • Dispatch guideline adherence and response interval-a study of emergency medical calls in Norway 

      Ellensen, Eirin Nybø; Wisborg, Torben; Hunskaar, Steinar; Zakariassen, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-13)
      Background:<br> The Emergency Medical Communication Centre (EMCC) operators in Norway report using the Norwegian Index for Medical Emergency Assistance (Index), a criteria-based dispatch guideline, in about 75 % of medical emergency calls. The main purpose of a dispatch guideline is to assist the operator in securing a correct response as quickly as possible. The effect of using the guideline on ...

    • Dissection of the internal carotid artery and stroke after mandibular fractures: a case report and review of the literature 

      Tveita, Ingrid Aune; Madsen, Martin Ragnar Skjerve; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-02)
      Background: We present a report of a patient with blunt trauma and mandibular fractures who developed a significant cerebral infarction due to an initially unrecognized injury of her left internal carotid artery. We believe that increased knowledge of this association will facilitate early recognition and hence prevention of a devastating outcome. <br>Case presentation: A 41-year-old ethnic ...

    • Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study 

      Synnestvedt, Marit; Borgen, Elin; Wist, Erik; Wiedswang, Gro; Weyde, Kjetil; Risberg, Terje; Kersten, Christian; Mjaaland, Ingvil; Vindi, Lise; Schirmer, Cecilie; Nesland, Jahn M; Naume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-12-22)
      Background: Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identify adjuvant insufficiently treated patients to be offered secondary adjuvant treatment intervention, and as a surrogate marker for therapy response.<p> <p>Methods: A total of ...

    • The distribution of hand fractures at the university hospital of north Norway 

      Weum, Sven; Millerjord, Siri; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-06)
      BACKGROUND: The objective of this study was to describe the fracture pattern for hand fractures in the Arctic region of Norway. MATERIALS AND METHODS: Using the hospital's radiological information system and picture archiving and communication system all traumatic hand fractures in the year of 2010 were registered. Fractures in the carpal, metacarpal, and phalangeal bones were included in the ...

    • District nursing between the local and the international. Northern Norway 1890-1940. 

      Elstad, Ingunn (Working paper; Arbeidsnotat, 2006)
      The article explores the history of voluntary district nursing in Northern Norway 1880- 1940. A popular movement of women’s associations met the tuberculosis epidemic, which peaked late in the North. District nursing was developed partly from the European movement of Christian relief and sick care, partly from local traditions of neighbourly assistance. Local girls were trained and employed by local ...

    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-10)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR). Oxidative stress is counteracted by antioxidants and oxidative repair mechanisms regulated by the transcription factor ...

    • Diverting stomas reduce reoperation rates for anastomotic leak but not overall reoperation rates within 30 days after anterior rectal resection: a national cohort study 

      Myrseth, Elisabeth; Nymo, Linn Såve; Gjessing, Petter Fosse; Norderval, Stig (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-24)
      Purpose A diverting stoma is commonly formed to reduce the rate of anastomotic leak following anterior resection with anastomosis, although some studies question this strategy. The aim of this study was to assess the leak rates and overall complication burden after anterior resection with and without a diverting stoma.<p> <p>Methods A 5-year national cohort with prospectively registered data of ...

    • DNA Damage Response 

      Oksenych, Valentyn; Kainov, Denis (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)

    • DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis 

      Taman, Hagar; Fenton, Christopher Graham; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)
      Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease ...

    • DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma 

      Haider, Zahra; Landfors, Mattias; Golovleva, Irina; Erlanson, Martin; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Norén-Nyström, Ulrika; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)
      Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ...

    • DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 

      Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flægstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      <p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...

    • Dna methylation-based subtype prediction for pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Zachariadis, Vasilios; Cavelier, Lucia; Dahlberg, Johan; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Overnäs, Elin; Abrahamsson, Jonas; Flægstad, Trond; Heyman, Mats M.; Jónsson, Ólafur G.; Kanerva, Jukka; Larsson, Rolf; Palle, Josefine; Schmiegelow, Kjeld; Gustafsson, Mats G.; Lönnerholm, Gudmar; Forestier, Erik; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)
      Background: We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into ...

    • Do dentists have better oral health compared to general population: A study on oral health status and oral health behavior in Kathmandu, Nepal 

      Wagle, Madhu; Trovik, Tordis A; Basnet, Purusotam; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Do diabetes mHealth and online interventions evaluate what is important for users? 

      Larbi, Dillys; Bradway, Meghan; Randine, Pietro; Antypas, Konstantinos; Gabarron, Elia; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11)
      Research often presents patient needs from perceptions of healthcare professionals and researchers. Today, patients can formulate tailored questions and seek solutions for what they need to self-manage in many ways. We aimed to compare reported outcomes of mHealth and online intervention studies for diabetes selfmanagement to patient-reported needs, from a systematic review and a literature review ...