English
norskBlar i tittel Artikler, rapporter og annet (klinisk medisin)
Viser treff 735-754 av 1796
-
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects against thrombosis. In this study, we investigated whether plasma MASP-2 levels were associated with risk of future venous thromboembolism (VTE) and whether genetic variants linked to ... -
High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several new therapies that target protein kinases have been implemented, and many more are becoming available. We have investigated lung cancer specimens for somatic mutations in a targeted ... -
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background - C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) is unknown. We assessed the association of plasma C1INH levels and VTE risk and evaluated the impact of C1INH on thrombin and plasmin generation in ex vivo assays.<p> <p>Methods - ... -
High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-08)<p><i>Purpose - </i>Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with ... -
High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively associated with the quality of sperm cell and ... -
High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
High-density lipoprotein subfractions: Much ado about nothing or clinically important?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total amount of HDL is inversely related to the risk of coronary heart disease (CHD), there has been ... -
High-performing trauma teams: frequency of behavioral markers of a shared mental model displayed by team leaders and quality of medical performance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-10)Background:<br>High quality team leadership is important for the outcome of medical emergencies. However, the behavioral marker of leadership are not well defined. The present study investigated frequency of behavioral markers of shared mental models (SMM) on quality of medical management.<br>Method:<br>Training video recordings of 27 trauma teams simulating emergencies were analyzed according to ... -
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ... -
High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ... -
Hip fracture treatment in Norway deviation from evidence-based treatment guidelines: data from the Norwegian Hip Fracture Register, 2014 to 2018
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-14)<i>Aims</i> - The aim of this study was to describe variation in hip fracture treatment in Norway expressed as adherence to international and national evidence-based treatment guidelines, to study factors influencing deviation from guidelines, and to analyze consequences of non-adherence.<p> <p><i>Methods</i> - International and national guidelines were identified and treatment recommendations ... -
Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02)Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging and in endocrine disorders. Several brain areas express receptors for GH although their functional role is unclear. To determine how GH affects the capacity for learning and memory by specific actions in one of the key areas, the hippocampus, we injected recombinant adeno-associated viruses (rAAVs) ... -
Hippocampus-Avoidance Whole-Brain Radiation Therapy Is Efficient in the Long-Term Preservation of Hippocampal Volume
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-19)Background and Purpose: With improved life expectancy, preventing neurocognitive decline after cerebral radiotherapy is gaining more importance. Hippocampal damage has been considered the main culprit for cognitive deficits following conventional whole-brain radiation therapy (WBRT). Here, we aimed to determine to which extent hippocampus-avoidance WBRT (HA-WBRT) can prevent hippocampal atrophy ... -
Histological and ultrastructural degenerative findings in the gluteus medius tendon after hip arthroplasty
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)<i>Background</i> - Despite gluteus medius (GMED) tendinosis being relatively common, its presence in association with hip osteoarthritis (OA) or total hip arthroplasty (THA) is not well studied. It was hypothesized that more tendon degeneration would be found in patients with OA of the hip and in those that had undergone THA than that in a control group.<br><br> <i>Methods</i> - One hundred ... -
History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ... -
The history of the case report: a selective review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
HIV patients with latent tuberculosis living in a low-endemic country do not develop active disease during a 2 year follow-up; a Norwegian prospective multicenter study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis
(Conference object; Konferansebidrag, 2008-09-15) -
Hoffmann´s syndrome necessitating forearm fasciotomy: a case report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-02)<i>Background</i> - Hoffmann’s syndrome is a rare form of hypothyroid myopathy. Only a few cases of fasciotomy in this setting have previously been reported.<p><p> <i>Case presentation</i> - A 41-year-old Caucasian man under treatment for hypothyroidism presented with acute-onset severe pain in his forearm for no obvious reason and was admitted to our emergency room. He eventually developed ... -
Hofteleddsdysplasi hos spedbarn – screening, behandling og oppfølging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)Hofteleddsdysplasi forkommer hos opptil 3 % av nyfødte og kan ubehandlet føre til luksert hofteledd, osteoartritt og behov for hofteprotese. Målet med studien var å kartlegge rutiner for ultralydscreening, behandling og oppfølging av hofteleddsdysplasi ved norske sykehus.
