Blar i tittel Artikler, rapporter og annet (klinisk medisin)

Viser treff 989-1008 av 1796

    • A longitudinal follow-up of autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Oftedal, Bergithe Eikeland; Landegren, Nils; Erichsen, Martina Moter; Bratland, Eirik; Lima, Kari; Jørgensen, Anders Palmstrøm; Myhre, Anne Grethe; Svartberg, Johan; Fougner, Kristian J; Bakke, Åsne; Nedrebø, Bjørn Gunnar; Mella, Bjarne; Breivik, Lars Ertesvåg; Viken, Marte K; Knappskog, Per; Cuida Marthinussen, Ileana Mihaela; Løvås, Kristian; Kämpe, Olle; Wolff, Anette Susanne Bøe; Husebye, Eystein Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-02)
      <b>Context:</b> Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insuffi- ciency, and chronic mucocutaneous candidiasis (CMC). Information on longitudinal follow-up of APS1 is sparse. <b>Objective:</b> To describe the phenotypes of APS1 and correlate the ...

    • Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia 

      Nystad, Mona; Sitras, Vasilis; Flo, Kari; Widnes, Christian; Vårtun, Åse; Wilsgaard, Tom; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
      Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ...

    • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

      Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
      <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...

    • A Longitudinal Study of Semantic Networks in Schizophrenia and other Psychotic Disorders Using the Word Association Task 

      Pintos, Andrea Stephanie; Hui, Christy Lai-Ming; De Deyne, Simon; Cheung, Charlton; Ko, Wai Tung; Nam, Suen Yi; Chan, Sherry Kit-Wa; Chang, Wing-Chung; Lee, Edwin Ho-Ming; Lo, Alison Wai-Fan; Lo, Tak-Lam; Elvevåg, Brita; Chen, Eric Yu-Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-24)
      The underpinnings of language deviations in psychotic symptoms (eg, formal thought disorder, delusions) remain unclear. We examined whether the semantic networks underlying word associations are useful predictors of clinical outcomes in psychosis. Fifty-one patients with schizophrenia and other psychotic disorders and 51 matched healthy controls generated words in a Cantonese continued word ...

    • Longterm Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort. 

      Glerup, Mia; Stoustrup, Peter Bangsgaard; Matzen, Louise Hauge; Rypdal, Veronika Gjertsen; Nordal, Ellen Berit; Frid, Paula; Arnstad, Ellen Dalen; Rygg, Marite; Thorarensen, Olafur; Ekelund, Maria; Berntson, Lillemor; Fasth, Anders; Nilsson, H; Peltoniemi, Suvi; Aalto, Kristiina; Arte, Sirpa; Toftedal, Peter; Nielsen, Susan; Kreiborg, S.; Herlin, T; Pedersen, T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)
      <i>Objective</i> - To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.<p> <p><i>Methods</i> - Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ ...

    • Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ...

    • Low CD4/CD8 ratio is associated with lower immunoglobulin levels in granulomatosis with polyangiitis patients receiving rituximab 

      Besada, Emilio; Nossent, Johannes C (Journal article; Tidsskriftartikkel, 2014-09-03)

    • Low CD4/CD8 ratio is associated with lower immunoglobulin levels in granulomatosis with polyangiitis patients receiving Rituximab 

      Besada, Emilio; Nossent, Johannes C (Journal article; Tidsskriftartikkel, 2014)

    • Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis 

      Graf, S; Lester, Susan; Nossent, Johannes C; Hill, C; Proudman, S. M; Lee, A; Rischmueller, Maureen (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-02-07)
      Introduction: Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether ...

    • Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry 

      Rinde, Fridtjof Balteskard; Jørgensen, Camilla Tøvik; Pettersen, Heidi Hassel; Hansen, John Bjarne; Ghanima, Waleed; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Background: Venous thromboembolism (VTE) is a frequent disease with a high risk of recurrence. It has been suggested that the D-dimer level at the time of VTE diagnosis can be used to identify patients at a low risk of recurrence. Objectives: We aimed to investigate the impact of D-dimer levels measured at the time of VTE diagnosis on the risk of recurrence in a large cohort of patients with a ...

    • Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer 

      Knappskog, Stian; Chrisanthar, Ranjan; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Leirvaag, Beryl; Miletic, Hrvoje; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-15)
      <i>Introduction</i>: Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNA-damaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and Chk2 in response to genotoxic stress. Here, we sought to evaluate ATM's potential role in resistance to chemotherapy.<p> <p><i>Methods</i>: We sequenced <i>ATM</i> and ...

    • Low immunoglobulin levels increase the risk of severe hypogammaglobulinemia in granulomatosis with polyangiitis patients receiving rituximab 

      Besada, Emilio (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-06)
      Background: Randomized controlled trials and retrospective studies in ANCA-associated vasculitis (AAV) concurred that rituximab (RTX) is effective to induce and maintain remission. Infections and hypogammaglobulinemia during RTX were usually infrequent and uncomplicated. But in the Tromsø study cohort, 45 % of patients with granulomatosis with polyangiitis (GPA) developed hypogammaglobulinemia ...

    • Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients 

      Smedbråten, Julia; Mjøen, Geir; Hartmann, Anders; Åsberg, Anders; Rollag, Halvor; Mollnes, Tom Eirik; Sandvik, Leiv; Fagerland, Morten W.; Thiel, Steffen; Sagedal, Solbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-18)
      Background: Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient’s native immune system. The complement system is an essential component of the innate immunity. The aim of the present study was to investigate the association of effector molecules of the lectin complement pathway with ...

    • Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia 

      Siljan, William Ward; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-05)
      <p><i>Background - </i>Disease severity and outcome in community-acquired pneumonia (CAP) depend on the host and on the challenge of the causal microorganism(s). We measured levels of immunoglobulins (Igs) and complement in 257 hospitalized adults with CAP and examined the association of low levels of Igs or complement to microbial etiology, disease severity, and short-term and long-term ...

    • Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy 

      Lorén, Christina E.; Dahl, Christen Peder; Do, Lan; Almaas, Vibeke; Geiran, Odd; Mörner, Stellan; Hellman, Urban (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
      During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the development of cardiac hypertrophy and fibrosis. The aim of this study was to ...

    • Low oxygen saturation and mortality in an adult cohort; the Tromsø Study 

      Vold, Monica Linea; Aasebø, Ulf; Wilsgaard, Tom; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-12)
      Background: Oxygen saturation has been shown in risk score models to predict mortality in emergency medicine. The aim of this study was to determine whether low oxygen saturation measured by a single-point measurement by pulse oximetry (SpO2) is associated with increased mortality in the general adult population. <p>Methods: Pulse oximetry was performed in 5,152 participants in a cross-sectional ...

    • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

      Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
      <p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...

    • Lower respiratory tract infections appear to be the most important risk factor for current asthma in subarctic schoolchildren. 

      Hansen, Tonje Elisabeth; Evjenth, Bjørg; Holt, jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      <p><i>Aim - </i>The aim of this study was to identify possible risk factors for current asthma revealed by two studies in Northern Norway in 1985 and 2008 and to evaluate these factors contributing to the increased prevalence of asthma over these 23 years. <p><i>Methods - </i>As part of the ‘Asthma and allergy study among schoolchildren in Nordland county’ we performed a case–control study (70.0% ...

    • Lumbar total disc replacement: predictors for long-term outcome 

      Furunes, Håvard; Hellum, Christian; Brox, Jens Ivar; Rossvoll, Ivar; Espeland, Ansgar; Berg, Linda; Brøgger, Helga Maria; Småstuen, Milada C; Storheim, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-04)
      Purpose: We aimed to identify patient characteristics associated with favourable long-term outcomes after lumbar total disc replacement (TDR). <br>Methods: We analysed a cohort of 82 patients with degenerative disc and chronic low back pain (LBP) who were treatedwith TDR and originally participated in a randomised trial comparing TDR and multidisciplinary rehabilitation. Potential predictors were ...

    • Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis. 

      Kilvær, Thomas Karsten; Paulsen, Erna-Elise; Hald, Sigurd; Wilsgaard, Tom; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-25)
      Background In non-small cell lung cancer (NSCLC), nodal metastasis is an adverse prognostic factor. Several mediating factors have been implied in the development of nodal metastases and investigated for predictive and prognostic properties in NSCLC. However, study results differ. In this structured review and meta-analysis we explore the published literature on commonly recognized pathways for ...