Artikler, rapporter og annet (klinisk medisin): Recent submissions
Now showing items 821-840 of 1805
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Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the development of cardiac hypertrophy and fibrosis. The aim of this study was to ... -
Safety and Outcomes of Tenecteplase in Moderate and Severe Ischemic Stroke. Results From NOR-TEST
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-08)<p><i>Background and Purpose — </i>Tenecteplase represents a promising alternative to alteplase as thrombolytic treatment in acute ischemic stroke. There are limited data on tenecteplase 0.4 mg/kg in patients with increased stroke severity. We aimed to assess safety and efficacy of tenecteplase 0.4 mg/kg in patients with moderate and severe ischemic stroke. <p><i>Methods — </i>NOR-TEST (Norwegian ... -
Effect of Hypnotherapy in Alcohol Use Disorder Compared with Motivational Interviewing: A Randomized Controlled Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-01)<i>Background</i>: Hypnotherapy has proved to be effective for the treatment of several medical and psychiatric conditions. It has been used in the treatment of alcohol use disorder (AUD), but only 2 randomized controlled trials have been conducted for this disorder.<p><p> <i>Methods</i>: This study was carried out at an inpatient clinic in Norway. A 6-week long treatment program included intensive ... -
Applying speech technologies to assess verbal memory in patients with serious mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-11)Verbal memory deficits are some of the most profound neurocognitive deficits associated with schizophrenia and serious mental illness in general. As yet, their measurement in clinical settings is limited to traditional tests that allow for limited administrations and require substantial resources to deploy and score. Therefore, we developed a digital ambulatory verbal memory test with automated ... -
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-08)Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, ... -
Incidence of gynecological fistula and its surgical treatment: A national registry-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-19)<i>Introduction</i> - Gynecological fistula (affecting female genital organs) leads to involuntary loss of urine or feces. In industrialized societies, fistulas occur mostly as complications of surgery, radiation therapy or inflammatory bowel disease. We sought to determine the incidence of gynecological fistula and type of surgical treatment provided in Norway.<p><p> <i>Material and methods</i> ... -
Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-09)Using complete information on total treatment burden, this population‐based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway identified 5,625 1‐year TCS diagnosed 1980–2009. Standardized incidence ratios (SIRs) were calculated to evaluate the total and site‐specific incidence of SC compared to the ... -
Isoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol: An experimental study in pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)<i>Purpose</i>: To compare two clinically relevant anesthetic agents, i.e., isoflurane versus propofol with respect to protection of the kidney in a porcine renal ischemia reperfusion model. <p> <p><i>Materials and Methods</i>: 14 hybrid pigs were randomized to anesthesia with either isoflurane or propofol prior to laparoscopic surgery. Following anesthesia, the left kidney hilum was clamped for ... -
Sex-specific reference ranges of cerebroplacental and umbilicocerebral ratios: A longitudinal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-10)<p><i>Objectives - </i>The ratio of middle cerebral artery (MCA) pulsatility index (PI) to umbilical artery (UA) PI, i.e. cerebro‐placental ratio (CPR), has been suggested as a measure of fetal “brain sparing” phenomenon reflecting redistribution of fetal cardiac output as a response to placental insufficiency. Observational studies have shown that low CPR values predict increased risk of adverse ... -
Myocardial infarction as a transient risk factor for incident venous thromboembolism: Results from a population-based case-crossover study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-16)Patients with myocardial infarction (MI) are at increased short-term risk of venous thromboembolism (VTE). The mechanisms behind this association are unclear. We aimed to investigate the impact of acute MI as a transient risk factor for incident VTE while taking other concomitant VTE risk factors into account. We conducted a case–crossover study of VTE patients (<i>n</i> = 707) recruited from the ... -
Amnioexchange for gastroschisis does not help, and may even harm
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)This is a mini commentary on D Luton et al., pp. 1233–1241 in this issue. To view this article visit https://doi.org/10.1111/1471-0528.15804. -
Initiation of systemic therapy during the last 30 days of life in patients with metastatic castration-resistant prostate cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019)<b>Background/Aim</b>: Compared to intravenous taxane chemotherapy, newer orally-available and/or less toxic agents for metastatic castration-resistant prostate cancer (MCRPC) may be associated with higher likelihood of starting treatment in patients with adverse prognostic features and limited life expectancy. To test this hypothesis, we analyzed the rates of treatment initiation during the last ... -
Fetal and neonatal alloimmune thrombocytopenia - The Norwegian management model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-31)In Norway, the management strategy for fetal and neonatal alloimmune thrombocytopenia (FNAIT) has for more than two decades differed from most other countries. The focus of this paper is to describe and discuss the Norwegian FNAIT management program. We recommend antenatal IVIg to women who previously have had a child with FNAIT-induced ICH, and usually not to HPA-1a alloimmunized pregnant women ... -
Measuring the effects of sharing mHealth data during diabetes consultations: a mixed-method study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-10)<i>Background</i>: There is rising demand for health care’s limited resources. Mobile health (mHealth) could be a solution, especially for those with chronic illnesses such as diabetes. mHealth can increases patients’ options to self-manage their health, improving their health knowledge, engagement, and capacity to contribute to their own care decisions. However, there are few solutions for sharing ... -
Psychiatric Risk Assessment from the Clinician´s Perspective: Lessons for the Future
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)Accurate prediction of risk-states in Serious Mental Illnesses (SMIs) is critical for reducing their massive societal burden. Risk-state assessments are notably inaccurate. Recent innovations, including widely available and inexpensive mobile technologies for ambulatory “biobehavioral” data, can reshape risk assessment. To help understand and accelerate clinician involvement, we surveyed 90 ... -
Second re-irradiation: A delicate balance between safety and efficacy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)Except for straightforward palliative indications such as painful bone metastases, re-irradiation is often characterized by a narrow therapeutic window and the potential for decreased efficacy and increased toxicity, especially if the cumulative total dose from both courses is high. Second re-irradiations tend to pose even bigger challenges and are thus offered in a restrictive manner to highly ... -
Simuleringsbasert teamtrening virker
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-09)Trening av tverrprofesjonelle team med bruk av simulering brukes særlig ved forberedelse til akuttmedisinske situasjoner. Det foreligger nå god dokumentasjon for at slik trening har betydning for pasientene. 27. mars 1977 skjedde verdens hittil verste flykatastrofe, der 583 personer omkom på Tenerife etter at to jumbojeter kolliderte på flyplassen i tett tåke. Granskningen etter katastrofen ... -
Hospitalization as a trigger for venous thromboembolism – Results from a population-based case-crossover study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-21)<i>Background</i> - Previous studies have reported that around 50% of patients with venous thromboembolism (VTE) has undergone recent hospitalization. However, studies on the impact of hospitalization as a trigger factor for VTE are limited.<p><p> <i>Objectives</i> - To investigate the impact of hospitalization with and without concurrent immobilization as a trigger factor for VTE.<p><p> ... -
Agreement between anatomical M-mode and tissue Doppler imaging in the assessment of fetal atrioventricular annular plane displacement in uncomplicated pregnancies: A prospective longitudinal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)Aim To evaluate the level of agreement between M‐mode and pulsed‐wave tissue Doppler imaging (PW‐TDI) techniques in assessing fetal mitral annular plane systolic excursion (MAPSE), tricuspid annular plane systolic excursion (TAPSE) and septal annular plane systolic excursion (SAPSE) in a low‐risk population. Methods This prospective longitudinal study included healthy fetuses assessed from 18 to ... -
Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)Family studies have indicated that heritability explains 50-60% of the venous thromboembolism (VTE) events, and in recent years, several single nucleotide polymorphisms (SNPs) have been found to influence the VTE risk. Glycoprotein 6 (GP6) rs1613662, also known as T13254C, is an A/G single nucleotide variation in amino acid 219, which results in a serine to proline substitution affecting ...