The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA ...

Background: Reducing maternal mortality, neonatal mortality and under 5-year mortality are important targets addressed by the United Nations' Sustainable Development Goals. Despite studies reported an improvement in maternal and child health indicators, the progress achieved is not uniform across regions. Due to the increasing availability of mobile phones in low and middle-income countries, mHealth ...

Background: The prevalence of depressive symptoms may differ in various age groups. The aim of the study was to investigate the point-prevalence of depressive symptoms in the adult general population and in various age groups. The impact of sex, marital status, education, and social support on depressive symptoms was also explored.<p> <p>Methods: The population ≥40 years in the city of Tromsø, ...

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specifc variants and associated regions requires huge sample sizes1 . Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are signifcantly associated ...

BACKGROUND<p> <p>Older trauma patients are reported to receive lower levels of care than younger adults. Differences in clinical management between adult and older trauma patients hold important information about potential trauma system improvement targets. The aim of this study was to compare prehospital and early in-hospital management of adult and older trauma patients, focusing on time-critical ...

Introduction: Using a porcine model of accidental immersion hypothermia and hypothermic cardiac arrest (HCA), the aim of the present study was to compare effects of different rewarming strategies on CPB on need for vascular fluid supply, level of cardiac restitution, and cerebral metabolism and pressures.<p> <p>Materials and Methods: Totally sixteen healthy, anesthetized castrated male pigs were ...

PURPOSE. The purpose of this study was to investigate associations between cardiovascular risk factors and the thickness of retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and outer retina layers (ORL).<p> <p>METHODS. In this population-based study, we included participants from the Tromsø Study: Tromsø6 (2007 to 2008) and Tromsø7 (2015 to 2016). Persons with ...

We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLCMS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, and drug concentrations were analysed in samples from 547 patients, half with uncontrolled hypertension, and all treated with ≥ 2 antihypertensive drugs. For sample preparation, ...

Background There is scarce information on biopsy-verifed kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy fndings in children, and to investigate risk of kidney replacement therapy (KRT).<p> <p>Methods We conducted a retrospective long-term follow-up study of children included in the Norwegian Kidney Biopsy Registry (NKBR) ...

Hoveddelen av dataene fra Medisinsk fødselsregister (MFR) for 2019 ble publisert i juni i år. Data om mors helse før og under svangerskapet samt data fra nyfødtavdelingene er publisert nå i desember og er tilgjengelig i vår statistikkbank. MFR har i år pga. den pågående pandemien også hatt en ekstrapublisering med et utvalg av variabler for 2020 data. Sjekk våre nettsider for mer informasjon om ...