Artikler, rapporter og annet (klinisk medisin): Nye registreringer
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Study of the effects of 3 h of continuous cardiopulmonary resuscitation at 27°C on global oxygen transport and organ blood flow
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-16)<i>Aims</i>: Complete restitution of neurologic function after 6 h of pre-hospital resuscitation and in-hospital rewarming has been reported in accidental hypothermia patients with cardiac arrest (CA). However, the level of restitution of circulatory function during long-lasting hypothermic cardiopulmonary resuscitation (CPR) remains largely unknown. We compared the effects of CPR in replacing ... -
Posterior reversible encephalopathy syndrome, a clinically diverse and challenging disorder
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-14)The characterizing features of Posterior reversible encephalopathy syndrome (PRES) are broad and diverse, making early recognition and diagnosis challenging tasks. To illustrate the heterogeneous nature of PRES, we present three cases and discuss their clinical and radiological presentation. -
Electronic Health Use in a Representative Sample of 18,497 Respondents in Norway (The Seventh Tromsø Study - Part 1): Population-Based Questionnaire Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)<p><i>Background:</i> Electronic health (eHealth) services may help people obtain information and manage their health, and they are gaining attention as technology improves, and as traditional health services are placed under increasing strain. We present findings from the first representative, large-scale, population-based study of eHealth use in Norway. <p><i>Objective:</i> The objectives of ... -
Impact of Illness on Electronic Health Use (The Seventh Tromsø Study - Part 2): Population-Based Questionnaire Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)<p><i>Background:</i> Patients who suffer from different diseases may use different electronic health (eHealth) resources. Thus, those who plan eHealth interventions should take into account which eHealth resources are used most frequently by patients that suffer from different diseases. <p><i>Objective:</i> The aim of this study was to understand the associations between different groups of chronic ... -
The association between health information seeking on the internet and physician visits (The Seventh Tromsø Study - Part 4): Population-based questionnaire study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)Background: The internet is being widely used for seeking health information. However, there is no consensus on the association between health information seeking on the internet and the use of health care services. Objective: We examined the association between health information seeking via the internet and physician visits. In addition, we investigated the association between online health ... -
Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)Bloodstream infections (BSI) and sepsis are major causes of morbidity and mortality worldwide. Blood culture-based diagnostics usually requires 1–2 days for identification of bacterial agent and an additional 2–3 days for phenotypic determination of antibiotic susceptibility pattern. With the escalating burden of antimicrobial resistance (AMR) rapid diagnostics becomes increasingly important to ... -
Laeverin Protein Expression in Normal and Preeclamptic Placentas using Tissue Microarray Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-21)<p><i>Introduction - </i>Laeverin is a placenta‐specific protein that is normally expressed in the plasma membrane of human trophoblasts. In previous studies, we showed higher expression levels of laeverin gene in preeclamptic compared with normal placentas and found that laeverin protein was ectopically expressed in the cytoplasm of the preeclamptic placentas. Our objective was to investigate ... -
Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)<i>Purpose</i> - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).<p><p> <i>Patients and Methods</i> - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain ... -
Triple use of autologous amnion graft in the treatment of meningomyelocele and split cord malformation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-20)This article describes the triple use of autologous amnion graft as a new procedure in the treatment of myelomeningocele and in myelomeningocele with split cord malformation. The first amnion graft was used as a physical and mechanical barrier to protect the myelomeningocele (MMC) from desiccation and mechanical stress directly after birth. A second graft was used as a dura substitute to close the ... -
Extracorporeal rewarming from experimental hypothermia: Effects of hydroxyethyl starch versus saline priming on fluid balance and blood flow distribution
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)Rewarming by extracorporeal circulation (ECC) is the recommended treatment for accidental hypothermia patients with cardiac instability. Hypothermia, along with initiation of ECC, introduces major changes in fluid homeostasis and blood flow. Scientific data to recommend best practice use of ECC for rewarming these patients is lacking, and no current guidelines exist concerning the choice of priming ... -
The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-17)<i>Background</i> - Few reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of ... -
Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-06)Imaging of clinically relevant preclinical animal models is critical to the development of personalized therapeutic strategies for endometrial carcinoma. Although orthotopic patient-derived xenografts (PDXs) reflecting heterogeneous molecular subtypes are considered the most relevant preclinical models, their use in therapeutic development is limited by the lack of appropriate imaging modalities. ... -
Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-02)<p><i>Objective - </i>Cross-sectional data show elevated levels of circulating cytokines in psychiatric patients. The literature is divided concerning anti-inflammatory drugs’ ability to relieve symptoms, questioning a causal link between inflammatory pathways and psychiatric conditions. We hypothesised that the development of circulating cytokine levels is related to mental distress, and that this ... -
Maternal serum laeverin (aminopeptidase Q) measured in the first trimester of pregnancy does not predict preeclampsia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-22)<i>Objective</i>: The aim of this study was to compare the laeverin level in maternal serum from first trimester (11–14 weeks) of pregnancy between normal pregnancies and pregnancies that later developed preeclampsia (PE).<p><p> <i>Material and methods</i>: This was a case-cohort study. The laeverin concentration was measured in cases with preterm PE (<i>n</i> = 55), term PE (<i>n</i> = 95), and ... -
MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ... -
Exosome-like extracellular vesicles from MYCN-amplified neuroblastoma cells contain oncogenic miRNAs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)<p><i>Background:</i> In recent years, evidence has accumulated indicating that both normal and cancer cells communicate via the release and delivery of macromolecules packed into extracellular membrane vesicles. <p><i>Materials and Methods:</i> We isolated nano-sized extracellular vesicles from MYCN-amplified neuroblastoma cell lines using ultracentrifugation and exosome precipitation (Exoquick) ... -
Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-12)Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ... -
The importance of loneliness in psychotic-like symptoms: Data from three studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-19)Poor social connection or loneliness is a prominent feature of schizotypy and may exacerbate psychosis risk. Previous studies have examined the inter-relationships between loneliness and psychosis risk, but critically, they have largely been conducted in non-clinical samples or exclusively used laboratory questionnaires with limited consideration of the heterogeneity within schizotypy (i.e., positive, ... -
Trauma research in the Nordic countries,1995–2018 – a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-12)<i>Background</i> - Trauma is a major cause of mortality and reduced quality of life. Most trauma-related research originates from trauma centres, and there are limited available data regarding the treatment of trauma patients throughout the Nordic countries. These countries differ from economically similar countries due to their cold climate, mix of rural and urban areas, and the long distances ... -
Do diabetes mHealth and online interventions evaluate what is important for users?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11)Research often presents patient needs from perceptions of healthcare professionals and researchers. Today, patients can formulate tailored questions and seek solutions for what they need to self-manage in many ways. We aimed to compare reported outcomes of mHealth and online intervention studies for diabetes selfmanagement to patient-reported needs, from a systematic review and a literature review ...