The koff values of ligands unbinding to proteins are key parameters for drug discovery. Their predictions based on molecular simulation may under- or overestimate experiment in a system- and/or technique-dependent way. Here we use an established method infrequent metadynamics, based on the AMBER force field to compute the koff of the ligand iperoxo (in clinical use) targeting the muscarinic receptor ...

Objectives: To investigate final-year medical students' perspectives of general practitioners' competencies. A further aim of the study was to investigate which type of clinical problems is properly managed by GPs according to students.<p> <p>Methods: We conducted a qualitative study of 49 final year medical students from two programmes. Reflective writing statements were used to collect data. ...

Previously it has been found that an important risk buffering strategy in the Saami reindeer husbandry in Norway is the accumulation of large herds of reindeer as this increases long-term household viability. Nevertheless, few studies have investigated how official policies, such as economic compensation for livestock losses, can influence pastoral strategies. This study investigated the effect of ...

The reaction rate of the oxidative addition and CO insertion steps of methyl iodide with [Rh(PhCOCHCOPh)(CO)(P(OCH₂ ) ₃ CCH₃ )] are presented. Large negative experimental values for the activation entropy and results from a density functional theory computational chemistry study indicated trans addition of the CH₃ I to [Rh(PhCOCHCOPh)(CO)(P(OCH<su ...

Background. A moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease (CVD) mortality in comparison with low consumption. The mechanisms underlying this association are not clear and have been suggested to be caused by residual confounding. The main objective of this study was to separate the familial and individual risk for CVD mortality and all-cause mortality ...

Results of in situ U–Pb dating of calcite spherulites, cone-in-cone (CIC) calcite and calcite fibres from a calcareous concretion of the upper Ediacaran of Finnmark, Arctic Norway, are reported. Calcite spherulites from the innermost layers of the concretion yielded a lower intercept age of 563 ± 70 Ma, which, although imprecise, is within uncertainty of the age of sedimentation based on fossil ...

Purpose. To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods. This non-randomized retrospective study comprised 61 eyes with progressive keratoconus treated with epithelium-on CXL. Chemical epithelial penetration enhancement (benzalkonium chloride-containing local medication ...

<p><b>Background</b> Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public health concern. Little is still known about the long-term mental health of non-hospitalised patients with COVID-19 with varying illness severities. Our aim was to assess the prevalence of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general ...

<p><b>Background</b> Depression is associated with an increased risk of dementia. However, short follow-up times and lack of adjustment for familial factors in previous studies could influence this association. The purpose of the present study was to investigate the association between depression and subsequent dementia, while controlling for familial factors and with a follow-up of over 35 ...

I oktober 2019 mottok Veterinærinstituttet en innsendelse med 13 grams lakseyngel fra et settefiskanlegg i Nord-Norge. Det ble rapportert om vedvarende økt dødelighet etter dyppvaksinering. Andre kliniske funn var gjellelokkforkortelse av varierende grad. Det var observert få svimere, og fisken hadde god appetitt.