This paper aims to contribute to understanding how physically large and complex systems of systems (SoS) can be digitally modeled. Ensuring the modeled SoS accurately represents real-world systems is challenging. Due to the significant amount of interaction these models have with the actors using them throughout the design lifecycle, their reliability can often be unpredictable and typically degrade ...

In the US context, critics of court use of algorithmic risk prediction algorithms have argued that COMPAS involves unfair machine bias because it generates higher false positive rates of predicted recidivism for black offenders than for white offenders. In response, some have argued that algorithmic fairness concerns, either also or only, calibration across groups–roughly, that a score assigned to ...

Plasmids can impact the evolution of their hosts, e.g. due to carriage of mutagenic genes, through cross-talk with host genes or as result of SOS induction during transfer. Here we demonstrate that plasmids can affect the level of microindel mutations in the host genome. These mutations are driven by the production of single-stranded DNA molecules that invade replication forks at microhomologies and ...

Studies with monolingual speakers show that people predict upcoming linguistic elements during sentence processing. Linguistic prediction behavior has been found to be less consistent in studies with bilingual individuals performing in their non-native language and in neurotypical older monolingual adults. The present study utilized an eye-tracking paradigm to investigate whether bilingual younger ...

Background - Open partial nephrectomy (OPN) has previously been considered the gold standard procedure for treatment of T1 localized renal tumors. After introduction of robot assisted partial nephrectomy (RAPN) as an alternative method to OPN, OPN was gradually abandoned at our department. The aim of the study was to retrospectively compare the results of patients treated with either OPN or RAPN for ...

Objectives To evaluate the acute effect of exposure to a potentiation warm-up protocol compared to a usual warm-up program. <p>Design Randomized parallel control trial. <p>Setting Synthetic grass in the club’s facilities (Portugal). Participants Seventeen female football players (age: 23.9±3.9 years), were randomly allocated to a control (n=8) and an experimental group (n=9). To allocate the ...

Salt is often present in the snow overlying seasonal sea ice, and has profound thermodynamic and electromagnetic effects. However, its provenance and behaviour within the snow remain uncertain. We describe two investigations tracing upward brine movement in snow: one conducted in the laboratory and one in the field. The laboratory experiments involved the addition of dyed brine to the base of ...

Background - Limited research has explored balance problems as a prospective risk factor for cardiovascular disease (CVD). This study aimed to characterize the association between balance measures and the risk of incident CVD in a population of 70‐year‐olds.<p> <p>Methods and Results - From 2012 to 2022 a cohort of 4927 older individuals who were CVD free underwent balance assessments using a ...

Objectives - Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, thus linking metabolism with epigenetic regulation. However, still relatively little is known about the dynamics of histone acetylation and its dependence on metabolic processes, ...

Objectives - To map whether and how systematic reviews (SRs) with network meta-analysis (NMA) use presentation formats to report (a) structured evidence summaries – here defined as reporting of effects estimates in absolute effects with certainty ratings and with a method to rate interventions across one or more outcome(s) – and (b) NMA results in general.<p> <p>Study Design and Setting - We ...