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dc.contributor.advisorSørensen, Karen Kristine
dc.contributor.authorRønningen, Iselin
dc.date.accessioned2015-04-16T14:29:07Z
dc.date.available2015-04-16T14:29:07Z
dc.date.issued2014-04-15
dc.description.abstractTumor-associated macrophages (TAMs) play an important role in cancer-related inflammation. TAMs develop M2 polarization which may support tumor growth. Mannose receptor (MR) expression is a hallmark for this cell-subpopulation, and the MR has recently been suggested to be involved in TAM polarization. The aim of the study was to investigate the role of MR in TAM polarization and tumor development in a mouse melanoma model. Tumor growth rate and morphology, and gene expression of markers for different macrophage subpopulations were compared in tumors from MR-knockout (MR-KO) and wild-type (WT) mice. A key question was whether MR is necessary for TAM polarization, or just a marker for M2 polarized cells. Main results: The day of first visible tumor was delayed in MR-KO mice, but from then on the tumors grew with the same rate in both animal groups. There were no marked differences in tumor morphology and histological appearance between groups. TAMs were observed already at an early stage, and some of these cells were already M2 polarized. As M2 polarization happened in both MR-KO and wild-type mice, it is likely that the MR is not a driver of this process. However, it may have a role in early tumor development.en_US
dc.identifier.urihttps://hdl.handle.net/10037/7617
dc.identifier.urnURN:NBN:no-uit_munin_7206
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2014 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDMBI-3911en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en_US
dc.titleRole of the mannose receptor in tumor associated macrophages. Studies in a mouse melanoma modelen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)