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dc.contributor.authorMoens, Ugo
dc.contributor.authorRasheed, Kashif
dc.contributor.authorAbdulsalam, Ibrahim
dc.contributor.authorSveinbjørnsson, Baldur
dc.date.accessioned2016-02-18T12:12:33Z
dc.date.available2016-02-18T12:12:33Z
dc.date.issued2015-04-10
dc.description.abstractPolyomaviruses are non-enveloped, dsDNA viruses that are common in mammals, including humans. All polyomaviruses encode the large T-antigen and small t-antigen proteins that share conserved functional domains, comprising binding motifs for the tumor suppressors pRb and p53, and for protein phosphatase 2A, respectively. At present, 13 different human polyomaviruses are known, and for some of them their large T-antigen and small t-antigen have been shown to possess oncogenic properties in cell culture and animal models, while similar functions are assumed for the large T- and small t-antigen of other human polyomaviruses. However, so far the Merkel cell polyomavirus seems to be the only human polyomavirus associated with cancer. The large T- and small t-antigen exert their tumorigenic effects through classical hallmarks of cancer: inhibiting tumor suppressors, activating tumor promoters, preventing apoptosis, inducing angiogenesis and stimulating metastasis. This review elaborates on the putative roles of human polyomaviruses in some of the emerging hallmarks of cancer. The reciprocal interactions between human polyomaviruses and the immune system response are discussed, a plausible role of polyomavirus-encoded and polyomavirus-induced microRNA in cancer is described, and the effect of polyomaviruses on energy homeostasis and exosomes is explored. Therapeutic strategies against these emerging hallmarks of cancer are also suggested.en_US
dc.identifier.citationViruses 2015, 7(4):1871-1901en_US
dc.identifier.cristinIDFRIDAID 1236463
dc.identifier.doi10.3390/v7041871
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/10037/8508
dc.identifier.urnURN:NBN:no-uit_munin_8078
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rights.accessRightsopenAccess
dc.subjectpolyomavirusen_US
dc.subjectmicroRNAen_US
dc.subjectinflammationen_US
dc.subjectautophagyen_US
dc.subjectglucoseen_US
dc.subjecttherapyen_US
dc.subjectexosomesen_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en_US
dc.titleThe role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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