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dc.contributor.authorBorch, Kristin Benjaminsen
dc.contributor.authorBraaten, Tonje
dc.contributor.authorLund, Eiliv
dc.contributor.authorWeiderpass, Elisabete
dc.date.accessioned2016-03-08T12:29:29Z
dc.date.available2016-03-08T12:29:29Z
dc.date.issued2015-12-16
dc.description.abstractBackground: The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer. Our study will add to the knowledge on whether a modifiable behavior such as PA can improve survival. <p>Methods: We included 1,327 women with breast cancer from the population-based Norwegian Women and Cancer study, which enrolled women from 1991 to 2003. Breast cancer cases were identified through linkage to the Cancer Registry of Norway; date and cause of death were obtained from the National Register for Causes of Death through 31 December 2012. Self-reported pre- and post-diagnostic PA levels were assessed, and Cox proportional hazard regression and spline regression were used to evaluate the associations. <p>Results: Pre-diagnostic PA levels were not associated with all-cause or breast cancer-specific mortality. Post-diagnostic PA levels were associated with a significant trend (P < 0.001) of decreased all-cause and breast cancer-specific mortality, which was stronger among older women (aged 50–74 years) and did not differ across categories of body mass index. All-cause mortality (hazard ratio [HR] = 1.76, 95 % confidence interval [CI] 1.21–2.56) and breast cancer-specific mortality (HR = 2.05, 95 % CI 1.35–3.10) increased among women who reduced their post-diagnostic PA level. These values were similar among women whose maintained an inactive PA level pre- and post-diagnosis. <p>Conclusion: Overall, we observed a dose–response trend, with an inverse association between increased postdiagnostic PA level and all-cause and breast cancer-specific mortality, as well as a higher mortality risk among women who reduced their post-diagnostic PA levels. Our results are very promising for women with breast cancer, and indicate that health care professionals should consider adding PA as a part of primary cancer treatment.en_US
dc.descriptionPublished version, also at <a href=http://dx.doi.org/10.1186/s12885-015-1971-9> http://dx.doi.org/10.1186/s12885-015-1971-9</a>en_US
dc.identifier.citationBMC Cancer (2015) 15:967en_US
dc.identifier.cristinIDFRIDAID 1307115
dc.identifier.doi10.1186/s12885-015-1971-9
dc.identifier.issn1471-2407
dc.identifier.urihttps://hdl.handle.net/10037/8754
dc.identifier.urnURN:NBN:no-uit_munin_8332
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Forebyggende medisin: 804en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Preventive medicine: 804en_US
dc.subjectBreast canceren_US
dc.subjectPhysical activityen_US
dc.subjectSurvivalen_US
dc.subjectCohorten_US
dc.titlePhysical activity before and after breast cancer diagnosis and survival - the Norwegian women and cancer cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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