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dc.contributor.authorJain, Kanika
dc.contributor.authorKrause, Kirsten
dc.contributor.authorGrewe, Felix
dc.contributor.authorNelson, Gaven F
dc.contributor.authorWeber, Andreas PM
dc.contributor.authorChristensen, Alan C
dc.contributor.authorMower, Jeffrey P
dc.date.accessioned2016-03-09T08:54:32Z
dc.date.available2016-03-09T08:54:32Z
dc.date.issued2015-12-13
dc.description.abstractNuclear genome sequencing from extremophilic eukaryotes has revealed clues about the mechanisms of adaptation to extreme environments, but the functional consequences of extremophily on organellar genomes are unknown. To address this issue, we assembled the mitochondrial and plastid genomes from a polyextremophilic red alga, Galdieria sulphuraria strain 074 W, and performed a comparative genomic analysis with other red algae and more broadly across eukaryotes. The mitogenome is highlyreduced in size and genetic content and exhibits the highest guanine–cytosine skew of any known genome and the fastest substitution rate among all red algae. The plastid genome contains a large number of intergenic stem-loop structures but is otherwise rather typical in size, structure, and content in comparison with other red algae. We suggest that these unique genomic modifications result not only from the harsh conditions in which Galdieria lives but also from its unusual capability to grow heterotrophically, endolithically, and in the dark. These conditions place additional mutational pressures on the mitogenome due to the increased reliance on the mitochondrion for energy production, whereas the decreased reliance on photosynthesis and the presence of numerous stem-loop structures may shield the plastome from similar genomic stress.en_US
dc.descriptionThe following article appeared at Genome Biology and Evolution 2015,7(1) and may be found at <a href=http://dx.doi.org/10.1093/gbe/evu290>http://dx.doi.org/10.1093/gbe/evu290</a>en_US
dc.identifier.citationGenome Biology and Evolution 2015, 7(1):367-380en_US
dc.identifier.cristinIDFRIDAID 1226837
dc.identifier.doi10.1093/gbe/evu290
dc.identifier.issn1759-6653
dc.identifier.urihttps://hdl.handle.net/10037/8787
dc.identifier.urnURN:NBN:no-uit_munin_8375
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rights.accessRightsopenAccess
dc.subjectGaldieria sulphuraria,en_US
dc.subjectred algaeen_US
dc.subjectfacultative heterotrophyen_US
dc.subjectpolyextremophilyen_US
dc.subjectGC skewen_US
dc.subjectsubstitution rateen_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497en_US
dc.titleExtreme Features of the Galdieria sulphuraria Organellar Genomes: A Consequence of Polyextremophily?en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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