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dc.contributor.authorOlsen, Karina Standahl
dc.contributor.authorSkeie, Guri
dc.contributor.authorLund, Eiliv
dc.date.accessioned2016-03-17T07:32:24Z
dc.date.available2016-03-17T07:32:24Z
dc.date.issued2015-10-08
dc.description.abstractIn nutrigenomics, gene expression profiling is used to investigate transcriptional mechanisms associated with nutrients and diet. Blood samples collected in the framework of dietary interventions and epidemiological studies allow the use of humans as the model system, as opposed to using cell lines or animal models. Here, we review recent publications in the field of gene expression profiling, based on a systematic literature search focusing on studies from the last 5 years and including studies that investigated either single nutrients, foods, food groups, or dietary patterns. Findings highlight the role of inflammatory processes as key mediators of the association between diet and disease and point to the relevance of using blood as the target tissue in nutrigenomics. However, recurring challenges include study design issues, practical and statistical challenges, and biological interpretation of the results. Many of the published studies have small sample size, and given the nature of gene expression data, their conclusions have limited impact. These challenges should be addressed by future nutrigenomics studies in order to increase their relevance and validity.en_US
dc.descriptionAccepted manuscript version. The final publication is available at Springer via <a href=http://doi.org/10.1007/s13668-015-0143-5>http://doi.org/10.1007/s13668-015-0143-5</a>.en_US
dc.identifier.citationCurrent nutrition reports 2015, 4(4):377-386en_US
dc.identifier.cristinIDFRIDAID 1307919
dc.identifier.doi10.1007/s13668-015-0143-5
dc.identifier.issn2161-3311
dc.identifier.urihttps://hdl.handle.net/10037/8992
dc.identifier.urnURN:NBN:no-uit_munin_8582
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rights.accessRightsopenAccess
dc.subjectNutrigenomicsen_US
dc.subjectGene expressionen_US
dc.subjectTranscriptomicsen_US
dc.subjectBlooden_US
dc.subjectPBMCen_US
dc.subjectNutritionen_US
dc.subjectEpidemiologyen_US
dc.subjectDieten_US
dc.subjectNutrientsen_US
dc.subjectFooden_US
dc.subjectDietary patternsen_US
dc.subjectImmunologyen_US
dc.subjectInflammationen_US
dc.subjectStudy designen_US
dc.subjectInterventionen_US
dc.subjectCohorten_US
dc.subjectRCTen_US
dc.subjectmRNAen_US
dc.subjectWhole blooden_US
dc.subjectPreventionen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.titleWhole-Blood Gene Expression Profiles in Large-scale Epidemiological Studies: What Do They Tellen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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