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dc.contributor.authorLappegård, Jostein
dc.contributor.authorEllingsen, Trygve
dc.contributor.authorSkjelbakken, Tove
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorNjølstad, Inger
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorBrox, Jan
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2016-03-22T08:16:47Z
dc.date.available2016-03-22T08:16:47Z
dc.date.issued2015-08-20
dc.description.abstractRed cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until December 31, 2010. Cox regression models were used to calculate hazard ratios (HR) with 95 % confidence intervals (95 % CI) for stroke, adjusted for age, sex, body mass index, smoking, haemoglobin level, white blood cell count, thrombocyte count, hypertension, total cholesterol, triglycerides, self-reported diabetes, and red blood cell count. During a median follow-up of 15.8 years, 1152 participants experienced a first-ever stroke. A 1 % increment in RDW yielded a 13 % higher risk of stroke (multivariable HR: 1.13, 95 % CI: 1.07–1.20). Subjects with RDW in the highest quintile compared to the lowest had a 37 % higher risk of stroke in multivariable analysis (HR: 1.37, 95 % CI: 1.11–1.69). Subjects with RDW above the 95-percentile had 55 % higher risk of stroke compared to those in the lowest quintile (HR: 1.55, 95 % CI: 1.16–2.06). All risk estimates remained unchanged after exclusion of subjects with anaemia (n=1102). RDW was not associated with increased risk of death within one year or during the entire follow-up after an incident stroke. RDW is associated with incident stroke in a general population, independent of anaemia and traditional atherosclerotic risk factors.en_US
dc.descriptionAccepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of “Red cell distribution width is associated with future risk of incident stroke. The Tromsø study" is available online at <a href=http://doi.org/10.1160/TH15-03-0234>http://doi.org/10.1160/TH15-03-0234</a>.en_US
dc.identifier.citationThrombosis and Haemostasis 2015en_US
dc.identifier.cristinIDFRIDAID 1288509
dc.identifier.doi10.1160/TH15-03-0234
dc.identifier.issn0340-6245
dc.identifier.urihttps://hdl.handle.net/10037/9055
dc.identifier.urnURN:NBN:no-uit_munin_8645
dc.language.isoengen_US
dc.publisherSchattaueren_US
dc.relation.ispartofThe published version of this article is part of Lappegård, J. (2018). Red Cell Distribution Width (RDW) and future risk of arterial cardiovascular diseases. Doctoral thesis. <a href=http://hdl.handle.net/10037/12988>http://hdl.handle.net/10037/12988.
dc.relation.projectIDStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-012en_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectEpidemiological studiesen_US
dc.subjectstrokeen_US
dc.subjectrisk factorsen_US
dc.titleRed cell distribution width is associated with future risk of incident stroke. The Tromsø studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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