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dc.contributor.authorMalmo, Vegard
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorBønaa, Kaare
dc.contributor.authorLoennechen, Jan Pål
dc.contributor.authorEllekjær, Hanne
dc.date.accessioned2016-08-24T08:03:44Z
dc.date.available2016-08-24T08:03:44Z
dc.date.issued2016-06-11
dc.description.abstractBackground: Self-reported atrial fibrillation (AF) and diagnoses from hospital registers are often used to identify persons with AF. The objective of this study was to validate self-reported AF and hospital discharge diagnoses of AF among participants in a population-based study. Materials and methods: Among 50,805 persons who participated in the third survey of the HUNT Study (HUNT3), 16,247 participants from three municipalities were included. Individuals who reported cardiovascular disease, renal disease, or hypertension in the main questionnaire received a cardiovascular-specific questionnaire. An affirmative answer to a question on physician-diagnosed AF in this second questionnaire defined self-reported AF diagnoses in the study. In addition, AF diagnoses were retrieved from hospital and primary care (PC) registers. All AF diagnoses were verified by review of hospital and PC medical records. Results: A total of 502 HUNT3 participants had a diagnosis of AF verified in hospital or PC records. Of these, 249 reported their AF diagnosis in the HUNT3 questionnaires and 370 had an AF diagnosis in hospital discharge registers before participation in HUNT3. The sensitivity of self-reported AF in HUNT3 was 49.6%, specificity 99.2%, positive predictive value (PPV) 66.2%, and negative predictive value (NPV) 98.4%. The sensitivity of a hospital discharge diagnosis of AF was 73.7%, specificity 99.7%, PPV 88.5%, and NPV 99.2%. Conclusion: Use of questionnaires alone to identify cases of AF has low sensitivity. Extraction of diagnoses from health care registers enhances the sensitivity substantially and should be applied when estimates of incidence and prevalence of AF are studied.en_US
dc.description.sponsorshipThis study was supported by grants from the Norwegian Council on Cardiovascular Diseases, the Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and Technology, and the Department of Neuroscience at the Norwegian University of Science and Technology.en_US
dc.descriptionPublisher's version, source <a href=http://doi.org/10.2147/CLEP.S103346>http://doi.org/10.2147/CLEP.S103346</a>en_US
dc.identifier.citationClinical Epidemiology 2016:8 185–193en_US
dc.identifier.cristinIDFRIDAID 1368397
dc.identifier.doi10.2147/CLEP.S103346
dc.identifier.issn1179-1349
dc.identifier.urihttps://hdl.handle.net/10037/9523
dc.identifier.urnURN:NBN:no-uit_munin_9084
dc.language.isoengen_US
dc.publisherDove Medical Pressen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectatrial fibrillationen_US
dc.subjectepidemiologyen_US
dc.subjectdiagnosisen_US
dc.subjectquestionnaireen_US
dc.subjectvalidationen_US
dc.titleValidation of self-reported and hospital-diagnosed atrial fibrillation: The HUNT studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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