• The emerging COVID-19 research: dynamic and regularly updated science maps and analyses 

      Andersen, Njål; Bramness, Jørgen Gustav; Lund, Ingunn Olea (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-30)
      <i>Background</i> - The COVID-19 pandemic is a global public health emergency and experts emphasize the need for rapid and a high degree of communication and interaction between all parties, in order for critical research to be implemented. We introduce a resource (website) that provides bibliometric analysis showing the current content and structure of the published literature. As new research is ...
    • Explaining the association between anxiety disorders and alcohol use disorder: A twin study 

      Torvik, Fartein Ask; Rosenström, Tom Henrik; Gustavson, Kristin; Ystrøm, Eivind; Kendler, Kenneth S.; Bramness, Jørgen Gustav; Czajkowski, Nikolai Olavi; Reichborn-Kjennerud, Ted (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-05)
      <p><i>Background - </i>It is unknown whether social anxiety disorder (SAD) has a unique association with alcohol use disorder (AUD) over and beyond that of other anxiety disorders, how the associations develop over time, and whether the associations are likely to be causal. <p><i>Methods - </i>Diagnoses of AUD, SAD, generalized anxiety disorder, panic disorder, agoraphobia, and specific phobias ...
    • Exploring dog ownership in the lives of people with substance use disorder: a qualitative study 

      Kerr-Little, Andi; Bramness, Jørgen Gustav; Newberry, Ruth C.; Biong, Stian (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-27)
      Background: Recovery from substance use is commonly seen as a process of integrating social relationships and creating a sense of meaning in one’s life. Dog owners describe a close relationship with their dog that impacts many aspects of their everyday life. Yet for individuals with substance use disorder (SUD), little is known about how dog ownership could affect their lives. The aim of this study ...
    • Factors associated with the level of prolactin in patients under remission from Alcohol Use Disorder: A gender perspective 

      Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-07)
      Background: Prolactin mirrors the dopaminergic activity in the brain which is key to understanding alcohol use disorders (AUD). Still, patients with AUD are a heterogenous group and there seem to be gender differences in the relationship between alcohol use and the level of prolactin. In this study, we examined gender-wise relationship of alcohol use trait- and state-related factors with the level ...
    • GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample 

      Moe, Jenny Skumsnes; Bolstad, Ingeborg; Mørland, Jørg Gustav; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-14)
      Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single nucleotide polymorphisms (SNPs) from candidate gene studies on alcohol use disorder and depressive disorders, for association with alcohol consumption ...
    • Growing up with parental substance use disorder: The struggle with complex emotions, regulation of contact, and lack of professional support 

      Wangensteen, Turid; Bramness, Jørgen Gustav; Halsa, Astrid Dagmar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-20)
      The aim of the study was to explore young people's perceptions and reflections about growing up with parents who have substance use disorder (SUD). In qualitative inter-views with 12 young people (aged 13–26) and in an interpretative phenomenological analysis, we investigated their experiences of everyday life, of the relationships with the parents with SUD, and of conversations about this, both ...
    • High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders 

      Neupane, Sudan Prasad; Lien, Lars; Martinez, Priscilla; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Hestad, Knut; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-03)
      <p><i>Aims - </i>As major depression (MD) is often comorbid with alcohol‐use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)‐6, IL‐10, tumor necrosis factor (TNF), and interferon (IFN)‐γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. <p><i>Methods - </i>A ...
    • History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Toft, Helge Prytz; Lien, Lars; Bolstad, Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)
      Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ...
    • Hva slags medisinsk behandling fikk Fruen fra Havet? 

      Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      Fruen fra Havet handler om Ellida Wangels psykiske krise og dens løsning. Hennes mann, legen Johannes Wangel, framstår som bekymret og omsorgsfull. Det antydes at han gir henne medisiner, men det nevnes ikke hvilke. Mange har ment at Ibsen i stykket foregriper Freuds «snakkekur» med flere år. I denne artikkelen utforsker jeg de psykiske problemene Ellida har, hvilke legemidler det kunne være snakk ...
    • Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations 

      Chalabianloo, Fatemeh; Høiseth, Gudrun; Vold, Jørn Henrik; Johansson, Kjell Arne; Kringen, Marianne K.; Dalgard, Olav; Ohldieck, Christian; Druckrey-Fiskaaen, Karl Trygve; Aas, Christer Frode; Løberg, Else-Marie; Bramness, Jørgen Gustav; Fadnes, Lars T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Background: There is limited knowledge on the causes of large variations in serum methadone concentrations and dose requirements. Objectives: We investigated the impact of the degree of liver fibrosis on dose-adjusted steady-state serum methadone concentrations.<p> <p<Methods: We assessed the clinical and laboratory data of 155 Norwegian patients with opioid use disorder undergoing methadone ...
    • Incidence of SARS-CoV-2 and all-cause mortality in persons with co-occurring substance use disorder and mental illness during the pandemic: a Norwegian cohort study 

      Leonhardt, Marja; Bramness, Jørgen Gustav; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-28)
      Purpose - Most people were affected by the COVID-19 pandemic. Persons with co-occurring substance use disorder (SUD) and mental illness (MI) are already a marginalized group, with above average mortality. Thus, the study aim was to investigate SARS-CoV-2 incidence and mortality among persons with SUD/MI during the first two years of the pandemic.<p> <p>Methods - This historical cohort study merged ...
    • Inflammatory cytokines in alcohol use disorder patients are lower in smokers and users of smokeless tobacco 

      Bolstad, Ingeborg; Lien, Lars; Moe, Jenny Skumsnes; Pandey, Susmita; Toft, Helge; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background - Smoking and alcohol use often co-occur, and the use of nicotine-containing products is particularly common among persons with alcohol use disorder (AUD). Recent evidence shows that chronic alcohol use leads to inflammation through increased gut permeability and dysregulated cytokine levels. While cigarette smoking also has detrimental health effects, nicotine has immune dampening effects ...
    • Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Walby, Fredrik A; Myhre, Martin Øverlien; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      Background: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) ...
    • Levels of mental distress over 18 years after entering treatment for substance use disorders: A longitudinal cohort study 

      Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Skeie, Ivar; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-17)
      <i>Aims:</i> The aims were to investigate whether baseline characteristics and problematic substance use were related to change in mental distress over time in patients with substance use disorders during an 18-year period.<p> <p><i>Method:</i> This was a prospective, longitudinal study of patients followed for 18 years after entering specialised treatment for substance use disorders. A sample ...
    • Levels of Peripheral Circulating IL-6 and IL-10 Decrease Over Time Despite High Depression Burden in PTSD Patients 

      Bramness, Jørgen Gustav; Lien, Lars; Toft, Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-05)
      Background: Patients with combined depression symptoms and post-traumatic stress disorder (PTSD) often exhibit high levels of circulating inflammatory biomarkers as either a cause or consequence of their disease. We aimed to investigate how cytokines and depression symptoms develop with one-year follow-up and compare them with non-PTSD patients.<p> <p>Methods: The study had a longitudinal design ...
    • Longitudinal determinants of insomnia among patients with alcohol use disorder 

      Bolstad, Ingeborg; Toft, Helge; Lien, Lars; Moe, Jenny Skumsnes; Rolland, Benjamin; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Insomnia is common among patients with AUD and can impair quality of life and cognitive functioning, as well as cause psycho-social problems and increased risk of relapse. Nonetheless, determinants of insomnia in patients with AUD have scarcely been studied. We aimed to examine prevalence and development of self-perceived insomnia among inpatients in treatment for AUD, and to examine factors in ...
    • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

      Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
      <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...
    • Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications 

      Chalabianloo, Fatemeh; Fadnes, Lars T.; Johansson, Kjell Arne; Høiseth, Gudrun; Vold, Jørn Henrik; Kringen, Marianne K.; Spigset, Olav; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-20)
      Background: A considerable inter-individual variability has been reported in the relationship between methadone doses applied and serum concentrations achieved in methadone maintenance treatment. However, the underlying causes for this variability are not fully understood.<p> <p>Objectives: We investigated the influence of genetic, pathophysiological and pharmacological factors on serum methadone ...
    • Mortality and alcohol-related morbidity in patients with delirium tremens, alcohol withdrawal state or alcohol dependence in Norway: A register-based prospective cohort study 

      Bramness, Jørgen Gustav; Heiberg, Ina Heidi; Høye, Anne; Rossow, Ingeborg Margrete (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)
      Background and Aims: Little is known about long-term consequences of delirium tremens (DT). This study aimed to compare all-cause and cause-specific mortality and alcohol-related morbidity between patients with: (i) DT, (ii) alcohol withdrawal state (AWS) and (iii) alcohol dependence (AD). Design: A national longitudinal health registry study with linked data from the Norwegian Patient Registry ...
    • Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study 

      Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      <p><i>Background - </i>This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders. <p><i>Methods - </i>This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use disorders. At ...