Blar i forfatter "Fenton, Christopher Graham"

Viser treff 21-27 av 27

    • Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort 

      Olsen, Karina Standahl; Fenton, Christopher Graham; Frøyland, Livar; Waaseth, Marit; Paulssen, Ruth H; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      High blood concentrations of n-6 fatty acids (FAs) relative to n-3 FAs may lead to a “physiological switch” towards permanent low-grade inflammation, potentially influencing the onset of cardiovascular and inflammatory diseases, as well as cancer. To explore the potential effects of FA ratios prior to disease onset, we measured blood gene expression profiles and plasma FA ratios (linoleic ...

    • Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids 

      Edholm, Eva-Stina; Fenton, Christopher Graham; Mondot, Stanislas; Paulssen, Ruth H; Lefranc, Marie-Paule; Boudinot, Pierre; Magadan, Susana (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-18)
      In jawed vertebrates, two major T cell populations have been characterized. They are defined as α/β or γ/δ T cells, based on the expressed T cell receptor. Salmonids (family Salmonidae) include two key teleost species for aquaculture, rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar) which constitute important models for fish immunology and important targets for vaccine development. ...

    • Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e 

      Thiyagarajan, Dhivya; Fismen, Silje; Seredkina, Natalya; Jacobsen, Søren; Elung-Jensen, Thomas; Kamper, Anne-Lise; Fenton, Christopher Graham; Rekvig, Ole Petter; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Recent studies demonstrate that transformation of mild lupus nephritis into end-stage disease is imposed by silencing of renal DNaseI gene expression in (NZBxNZW)F1 mice. Down-regulation of DNaseI results in reduced chromatin fragmentation, and in deposition of extracellular chromatin-IgG complexes in glomerular basement membranes in individuals that produce IgG anti-chromatin antibodies. The main ...

    • Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients 

      Figenschau, Stine Linn; Fismen, Silje; Fenton, Kristin Andreassen; Fenton, Christopher Graham; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
      Background: Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs. Despite the described role of inflammation in tumor progression, it is still unclear whether the process of lymphoid neogenesis and biological function of ectopic lymphoid tissue in tumors are beneficial or detrimental to tumor growth. ...

    • Transcriptional profiling of ulcerative colitis in remission 

      Fenton, Christopher Graham; Taman, Hagar; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel, 2019-01-25)
      <p><i>Background - </i>This study addresses whether existing transcriptional profiles can improve and support the current definition of UC in remission apart from the today existing endoscopic, histological and laboratory scoring systems. <p><i>Methods - </i>Mucosal biopsies from treatment-naïve UC patients (<i>n</i> = 14), healthy controls (<i>n</i> = 16), and UC patients in remission (<i>n</i> = ...

    • Transcriptional signatures that define ulcerative colitis in remission 

      Fenton, Christopher Graham; Taman, Hagar; Florholmen, Jon; Sørbye, Sveinung; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-23)
      <i>Background</i> - This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was ...

    • Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)
      Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease that effects the gastrointestinal tract and is considered one of the most prominent and common forms of inflammatory bowel disease [IBD]. This study aimed to define and describe the entire transcriptomic landscape in a well-stratified, treatment-naïve UC patient population compared ...