Blar i forfatter "Hansen, John Bjarne"

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    • Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease 

      den Exter, Paul L.; Woller, Scott C.; Robert-Ebadi, Helia; Masias, Camila; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John Bjarne; Geersing, Geert-Jan; Siegal, Deborah M.; de Wit, Kerstin; Klok, Frederikus A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-20)
      Patients with acute venous thromboembolism (VTE) require anticoagulant therapy to prevent recurrent VTE and death, which exposes them to an inherent increased risk of bleeding. Identification of patients at high risk of bleeding, and mitigating this risk, is an essential component of the immediate and long-term therapeutic management of VTE. The bleeding risk can be estimated by either implicit ...

    • Optimized workflow to modify microRNA expression in primary human intravascular cells 

      Caglayan, Safak; Hansen, John Bjarne; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)
      Background - A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requires a specific and efficient knockdown or overexpression of the miRNA of interest; these are achieved by transfecting the cell of interest with a miRNA inhibitor or a miRNA mimic, respectively. Inhibitors and mimics of miRNAs with a unique chemistry and/or structural ...

    • Plasma levels of P-selectin and future risk of incident venous thromboembolism 

      Swamy, Samantha; Ueland, Thor; Hansen, John Bjarne; Snir, Omri; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel, 2023-05-12)
      Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE.<p> <p>Objectives - We aimed to investigate the association between plasma P-selectin levels and risk of future incident VTE.<p> <p>Methods ...

    • Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism 

      Snir, Omri; Wilsgård, line; Latysheva, Nadezhda; Ullsten-Wahlund, Casper; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-18)
      Background - Microvesicles (MVs) are small double‐membrane encapsulated particles shed from cells. Case‐control studies have reported elevated plasma levels of platelet‐derived MVs (PDMVs) in patients with venous thromboembolism (VTE). However, it is not known whether high PDMV levels is a risk factor or a consequence of the acute VTE event.<p> <p>Objectives - To investigate the association between ...

    • Plasma procoagulant phospholipid clotting time and venous thromboembolism risk 

      Ramberg, Cathrine; Wilsgård, line; Latysheva, Nadezhda; Brækkan, Sigrid Kufaas; Hindberg, Kristian; Sovershaev, Timofey; Snir, Omri; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
      Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL<sub>CT</sub>) and future risk of venous thromboembolism (VTE).<p> <p>Objectives - To investigate the ...

    • Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score 

      De Winter, Maria A.; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin A. H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik T.; Visseren, Frank L. J.; Wells, Philip S.; Dorresteijn, Jannick A. N.; Nijkeuter, Mathilde; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-17)
      Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed to develop and externally validate models for predicting 5-year risks of recurrence and bleeding in patients with VTE without cancer who completed at least 3 months of initial treatment, ...

    • Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis 

      de Winter, Maria A.; Uijl, Alicia; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin H.A.H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik Toft; Wells, Philip S.; Nijkeuter, Mathilde; Dorresteijn, Jannick A.N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-22)
      Background - Patients with venous thromboembolism (VTE) are commonly classified by the presence or absence of provoking factors at the time of VTE to guide treatment decisions. This approach may not capture the heterogeneity of the disease and its prognosis.<p> <p>Objectives - To evaluate clinically important novel phenotypic clusters among patients with VTE without cancer and to explore their ...

    • Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review 

      Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-28)
      Identification of individuals with ischemic stroke at particularly high risk of venous thromboembolism (VTE) is crucial for targeted thromboprophylaxis. To guide clinical decision-making and development of risk prediction models, increased knowledge on risk factors and biomarkers is needed. Therefore, we set out to identify risk factors and predictors for VTE in people with ischemic stroke by ...

    • The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study 

      Frischmuth, Tobias; Tøndel, Birgitte Gladsø; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-07)
      Background: Obesity is a well-established risk factor for venous thromboembolism (VTE). However, data on the proportion of incident VTEs attributed to overweight and obesity in the general population are limited.<p> <p>Objective: To investigate the population attributable fraction (PAF) of VTE due to overweight and obesity in a population-based cohort with repeated measurements of body mass index ...

    • The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes 

      Holtet Evensen, Line; Arnesen, Carl-Arne; Rosendaal, Frits Richard; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hveem, Kristian; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel, 2022-01-17)
      <p><i>Background -</i> The proportion of venous thromboembolism (VTE) events that can be attributed to established prothrombotic genotypes has been scarcely investigated in the general population. We aimed to estimate the proportion of VTEs in the population that could be attributed to established prothrombotic genotypes using a population-based case-cohort. <p><i>Methods -</i> Cases with incident ...

    • Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial 

      Ramberg, Cathrine; Hindberg, Kristian; Biedermann, Joseph S.; Cannegieter, Suzanne C.; van der Meer, Felix J.; Snir, Omri; Leebeek, Frank W. G.; Kruip, Marieke J. H. A.; Hansen, John Bjarne; Lijfering, Willem M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-25)
      Background - Venous thromboembolism (VTE) is a frequent cardiovascular disease with severe complications, including recurrence and death. There is a great need for alternative prophylactic treatment options as anticoagulation is accompanied by increased bleeding risk. Statins are reported to reduce the risk of incident and recurrent VTE, but the mechanisms are elusive. Procoagulant phospholipids ...

    • Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study 

      Meknas, Dana; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-20)
      Background Surgery is a major transient risk factor for venous thromboembolism (VTE). However, the impact of major surgery as a VTE trigger has been scarcely investigated using a case-crossover design.<p> <p>Aim To investigate the role of major surgery as a trigger for incident VTE in a population-based case-crossover study while adjusting for other concomitant VTE triggers. <p>Methods We ...

    • Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study 

      Crobach, Monique J.T.; Anijs, Rayna J.S.; Brækkan, Sigrid Kufaas; Severinsen, Marianne T.; Hammerstrøm, Jens; Skille, Hanne; Kristensen, Søren R.; Paulsen, Benedikte; Tjønneland, Anne; Versteeg, Henri H.; Overvad, Kim; Hansen, John Bjarne; Næss, Inger Anne; Cannegieter, Suzanne C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-28)
      Patients with cancer have an increased risk of developing venous thromboembolism (VTE), and this combination is reported to result in poorer survival compared with cancer alone. This study aimed to investigate the impact of VTE on the survival of patients with cancer in a general population. The Scandinavian Thrombosis and Cancer (STAC) cohort, a population-based cohort including 144 952 participants ...

    • Sustained and intermittent hypoxia differentially modulate primary monocyte immunothrombotic responses to IL-1β stimulation 

      Ullsten-Wahlund, Casper Jan Elis; Caglayan, Safak; Czarnewski, Paulo; Hansen, John Bjarne; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-11)
      Venous thromboembolism (VTE) is a leading cause of preventable deaths in hospitals, and its incidence is not decreasing despite extensive efforts in clinical and laboratory research. Venous thrombi are primarily formed in the valve pockets of deep veins, where activated monocytes play a crucial role in bridging innate immune activation and hemostatic pathways through the production of inflammatory ...

    • A systematic review of biomarkers among hospitalized patients with COVID-19 predictive of venous thromboembolism: A communication from the Predictive and Diagnostic Variables Scientific and Standardization Committee of the ISTH 

      Woller, Scott C.; de Wit, Kerstin; Robert-Ebadi, Helia; Masias, Camila; Klok, Frederikus A.; den Exter, Paul L.; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-26)
      <p><b> Background</b> Thrombosis is reported to occur more often among patients with COVID-19 than otherwise expected in the setting of viral pneumonia and sepsis. Systemic inflammatory biomarkers may be associated with venous thromboembolism (VTE) risk. The ISTH subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease aimed to report the evidence on prognostic biomarkers for VTE ...

    • Venous thromboembolism and risk of depression: a population-based cohort study 

      Jørgensen, Helle; Horvath-Puho, Erzsebet; Laugesen, Kristina; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Toft Sørensen, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-22)
      Background - The psychologic consequences of acute venous thromboembolism (VTE) have not been investigated in depth.<p> <p>Objectives We aimed to examine the association between VTE and the risk of subsequent depression.<p> <p>Methods - Using Danish nationwide registries, we established a population-based cohort of 64 596 individuals with incident VTE during 1996 to 2016 and a comparison ...

    • VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology 

      Brækkan, Sigrid Kufaas; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-17)
      Venous thromboembolism (VTE) is a frequent disease affecting more than 1 in 12 individuals during their lifetime. VTE is associated with a substantial disease burden due to long-term complications such as recurrence, the post-thrombotic syndrome, and the post-pulmonary embolism syndrome. Despite the knowledge of several risk factors and triggers, more than one third of the VTE events occur in the ...