The density ridge framework for estimating principal curves and surfaces has in a number of recent works been shown to capture manifold structure in data in an intuitive and effective manner. However, to date there exists no efficient way to traverse these manifolds as defined by density ridges. This is unfortunate, as manifold traversal is an important problem for example for shape estimation in ...

Gaussian process regression (GPR) has experienced tremendous success in biophysical parameter retrieval in the past years. The GPR provides a full posterior predictive distribution so one can derive mean and variance predictive estimates, i.e., point-wise predictions and associated confidence intervals. GPR typically uses translation invariant covariances that make the prediction function very ...

Distance-based classification is frequently used in transductive few-shot learning (FSL). However, due to the high-dimensionality of image representations, FSL classifiers are prone to suffer from the hubness problem, where a few points (hubs) occur frequently in multiple nearest neighbour lists of other points. Hubness negatively impacts distance-based classification when hubs from one class appear ...

A large fraction of the electronic health records (EHRs) consists of clinical measurements collected over time, such as lab tests and vital signs, which provide important information about a patient’s health status. These sequences of clinical measurements are naturally represented as time series, characterized by multiple variables and large amounts of missing data, which complicate the analysis. ...

Learning data representations that reflect the customers’ creditworthiness can improve marketing campaigns, customer relationship management, data and process management or the credit risk assessment in retail banks. In this research, we show that it is possible to steer data representations in the latent space of the Variational Autoencoder (VAE) using a semi-supervised learning framework and a ...

A large fraction of the Electronic Health Records consists of clinical multivariate time series. Building models for extracting information from these is important for improving the understanding of diseases, patient care and treatment. Such time series are oftentimes particularly challenging since they are characterized by multiple, possibly dependent variables, length variability and irregular ...

Tracer kinetic modelling, based on dynamic ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used to quantify glucose metabolism in humans and animals. Knowledge of the arterial input-function (AIF) is required for such measurements. Our aim was to explore two non-invasive machine learning-based models, for AIF prediction in a small-animal dynamic FDG PET study. 7 tissue ...

The lack of labeled data is a key challenge for learning useful representation from time series data. However, an unsupervised representation framework that is capable of producing high quality representations could be of great value. It is key to enabling transfer learning, which is especially beneficial for medical applications, where there is an abundance of data but labeling is costly and time ...

A recurrent neural network (RNN) is a universal approximator of dynamical systems, whose performance often depends on sensitive hyperparameters. Tuning them properly may be difficult and, typically, based on a trial-and-error approach. In this work, we adopt a graph-based framework to interpret and characterize internal dynamics of a class of RNNs called echo state networks (ESNs). We design principled ...