Blar i forfatter "Jenssen, Trond Geir"

Viser treff 21-40 av 54

    • GFR in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohorts 

      Eriksen, Bjørn Odvar; Pálsson, Runólfur; Ebert, Natalie; Melsom, Toralf; van der Giet, Markus; Gudnason, Vilmundur; Indridasson, Olafur S.; Inker, Lesley A.; Jenssen, Trond Geir; Levey, Andrew S.; Solbu, Marit Dahl; Tighiouart, Hocine; Schaeffner, Elke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07)
      <i>Background</i> - Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.<br><br> <i>Methods</i> - We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50–97 years in the general population through a meta-analysis of iohexol clearance measurements ...

    • Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro 

      Reine, Trine M.; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-23)
      <b>Purpose:</b> Glucosamine (GlcN) supplements are promoted for medical reasons, for example, for patients with arthritis and other joint-related diseases. Oral intake of GlcN is followed by uptake in the intestine, transport in the circulation and thereafter delivery to chondrocytes. Here, it is postulated to have an effect on synthesis and turnover of extracellular matrix constituents expressed ...

    • Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients 

      Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders; Jenssen, Trond Geir; Krarup, Henrik; Svensson, My Hanna Sofia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-22)
      Background:<br> Cardiovascular disease is the leading cause of death in renal transplant recipients (RTRs). An association between haptoglobin genotype 2 - 2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. <br>Methods:<br> In this single centre ...

    • Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress 

      Boardman, Neoma Tove; Falck, Aleksander Tank; Lund, Trine; Chu, X; Martin, Armas Maria Montserrat; Norvik, Jon Viljar; Jenssen, Trond Geir; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-14)
      Uric acid is a purine degradation product but also an important antioxidant and ROS scavenger. Experimental settings that mimic myocardial ischemia-reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on ...

    • Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population 

      Melsom, Toralf; Mathisen, Ulla Dorte; Ingebretsen, Ole C; Jenssen, Trond Geir; Njølstad, Inger; Solbu, Marit Dahl; Toft, Ingrid; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ...

    • Low adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Study 

      Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eggen, Anne Elise; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-14)
      Background: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. <br>Methods: We conducted a cross-sectional ...

    • Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant 

      Aasebø, Willy; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Eide, Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)
      Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.<p><p> <i>Methods</i> - In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose ...

    • Matrix metalloproteinase-9 mediated shedding of syndecan-4 in glomerular endothelial cells 

      Reine, Trine M.; Lanzalaco, Francesca; Kristiansen, Oddrun; Enget, Anne Randi; Satchell, Simon; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-31)
      <p><i>Background - </i>Diabetic nephropathy is the most common cause of end‐stage renal failure in the western world and Asia. The mechanisms are not fully elucidated, but disruption of glomerular endothelial glycocalyx and shedding of its components including syndecans has been implicated. <p><i>Aims - </i>We hypothesize that reduced glomerular filtration in diabetes is caused by disruption of ...

    • Microbubble contrast-enhanced ultrasound in the vascular evaluation after pancreas transplantation: a single-center experience 

      Berstad, Audun Elnæs; Brabrand, Knut; Horneland, Rune; Syversveen, Trygve; Haugaa, Håkon; Jenssen, Trond Geir; Foss, Aksel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-12)
      <i>Background</i> - Arterial and venous thrombosis are feared complications of pancreas transplantation (PTx). Microbubble contrast-enhanced ultrasound (CEUS) is a non-invasive imaging technique that can augment diagnostic capabilities of transplant organ perfusion.<p><p> <i>Purpose</i> - To document the state to which CEUS can improve the vascular evaluation of PTx compared to conventional ...

    • Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population 

      Melsom, Toralf; Solbu, Marit Dahl; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Norvik, Jon Viljar; Jenssen, Trond Geir; Wilsgaard, Tom; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)
      <i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ...

    • A multiparameter model for non-invasive detection of hypoglycemia 

      Elvebakk, Ole; Tronstad, Christian; Birkeland, Kåre I.; Jenssen, Trond Geir; Bjørgaas, Marit Ragnhild Rokne; Gulseth, Hanne Løvdal; Kalvøy, Håvard; Høgetveit, Jan Olav; Martinsen, Ørjan Grøttem (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-02)
      <i>Objective</i>: Severe hypoglycemia is the most serious acute complication for people with type 1 diabetes (T1D). Approximately 25% of people with T1D have impaired ability to recognize impending hypoglycemia, and nocturnal episodes are feared.<p> <p><i>Approach</i>: We have investigated the use of non-invasive sensors for detection of hypoglycemia based on a mathematical model which combines ...

    • N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population 

      Toft, Ingrid; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Eriksen, Bjørn Odvar; Melsom, Toralf; Njølstad, Inger; Wilsgaard, Tom; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
      Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ...

    • Obesity-related cardiovascular risk factors after weight loss : a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention 

      Hofsø, Dag; Nordstrand, Njord; Johnson, Line Kristin; Karlsen, Tor-Ivar; Hager, Helle; Jenssen, Trond Geir; Bollerslev, Jens; Godang, Kristin; Sandbu, Rune; Røislien, Jo; Hjelmesæth, Jøran (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Objective: Weight reduction improves several obesity-related health conditions. We aimed to compare the effect of bariatric surgery and comprehensive lifestyle intervention on type 2 diabetes and obesityrelated cardiovascular risk factors. Design: One-year controlled clinical trial (ClinicalTrials.gov identifier NCT00273104). Methods: Morbidly obese subjects (19–66 years, mean (S.D.) body mass ...

    • One-year protocol biopsies from ABO-incompatible renal allografts compared with a matched cohort of ABO-compatible allografts 

      Dörje, Christina; Mjøen, Geir; Strøm, Erik Heyerdahl; Holdaas, Hallvard; Jenssen, Trond Geir; Øyen, Ole; Akkøk, Cigdem Ahaein; Småstuen, Milada C; Midtvedt, Karsten; Reisæter, Anna Varberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-21)
      Abstract: Introduction: Early acute antibody-mediated rejection (ABMR) occurs more frequently in ABO-incompatible (ABOi) than in ABO-compatible (ABOc) kidney transplantation. This could lead to increased inflammation/scarring in the ABOi grafts. Protocol biopsy data in ABOi kidney recipients are scarce.<p> <p>Methods: A single-center retrospective matched cohort study was conducted. Eighty ...

    • Outcomes in pancreas transplantation with exocrine drainage through a duodenoduodenostomy versus duodenojejunostomy 

      Lindahl, Jørn Petter Hanto; Horneland, Rune; Nordheim, Espen; Hartmann, Anders; Aandahl, Einar Martin; Grzyb, Krzysztof; Haugaa, Håkon; Kjøsen, Gisle; Åsberg, Anders; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel, 2017-08-23)
      Until recently, pancreas transplantation has mostly been performed with exocrine drainage via duodenojejunostomy (DJ). Since 2012, DJ was substituted with duodenoduodenostomy (DD) in our hospital, allowing endoscopic access for biopsies. This study assessed safety profiles with DD versus DJ procedures and clinical outcomes with the DD technique in pancreas transplantation. DD patients (n = 117; 62 ...

    • Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study 

      Norvik, Jon Viljar; Storhaug, Hilde-Merete; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
      Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. <br> Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants ...

    • Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men : a cross-sectional study 

      Hjelmesæth, Jøran; Hofsø, Dag; Aasheim, Erlend T.; Jenssen, Trond Geir; Moan, Johan; Hager, Helle; Røislien, Jo; Bollerslev, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02-03)
      Background: The prevalence of vitamin D insufficiency and secondary hyperparathyroidism is high among morbidly obese subjects. Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between PTH and MS has been reported. Although it is well known that the synthesis and secretion ...

    • Patient selection for islet or solid organ pancreas transplantation: experiences from a multidisciplinary outpatient-clinic approach 

      Nordheim, Espen; Lindahl, Jørn Petter Hanto; Carlsen, Rasmus Kirkeskov; Åsberg, Anders; Birkeland, Kåre I.; Horneland, Rune; Boye, Birgitte; Scholz, Hanne; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02)
      Objective - β-cell replacement therapy (βCRT), including pancreas transplantation alone (PTA) and islet transplantation (ITX), is a treatment option for selected type 1 diabetes patients. All potential candidates for βCRT in Norway are referred to one national transplant centre for evaluation before any pre-transplant workup is started. This evaluation was performed by a transplant nephrologist alone ...

    • Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation 

      Skaare, Helga; Svensson, My Hanna Sofia; Jenssen, Trond Geir; Åsberg, Anders; Schmidt, Erik Berg; Chandra, Anupam; Ueland, Thor; Mollnes, Tom Eirik; Hartmann, Anders; Eide, Ivar Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-24)
      <p><i>Objective</i>: The major n-6 polyunsaturated fatty acids linoleic acid (LA) and arachidonic acid (AA) play a role in inflammation and glucose metabolism, which could affect patient and renal transplant survival.</p> <p><i>Design and methods</i>: In this single center cohort study of 1988 Norwegian renal transplant recipients, we assessed associations between plasma levels of LA and AA at ...

    • Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study 

      Melsom, Toralf; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Wilsgaard, Tom; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)