Blar i forfatter "Leon, David A."

Viser treff 21-24 av 24

    • Socioeconomic inequalities in physiological risk biomarkers and the role of lifestyles among Russians aged 35-69 years 

      Trias-Llimós, Sergi; Cook, Sarah; Eggen, Anne Elise; Kudryavtsev, Alexander V; Malyutina, Sofia; Shkolnikov, Vladimir M.; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-15)
      Background: Socioeconomic inequalities in cardiovascular (CVD) health outcomes are well documented. While Russia has one of the highest levels of CVD mortality in the world, the literature on contemporary socio-economic inequalities in biomarker CVD risk factors is sparse. This paper aims to assess the extent and the direction of SEP inequalities in established physiological CVD risk biomarkers, ...

    • Studying accelerated cardiovascular ageing in Russian adults through a novel deep-learning ECG biomarker 

      Benavente, Ernest Diez; Jimenez-Lopez, Francisco; Attia, Zachi I.; Malyutina, Sofia; Kudryavtsev, Alexander; Ryabikov, Andrey; Friedman, Paul A.; Kapa, Suraj; Voevoda, Michael; Perel, Pablo; Schirmer, Henrik; Hughes, Alun D.; Clark, Taane; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)
      Background: A non-invasive, easy-to-access marker of accelerated cardiac ageing would provide novel insights into the mechanisms and aetiology of cardiovascular disease (CVD) as well as contribute to risk stratification of those who have not had a heart or circulatory event. Our hypothesis is that differences between an ECG-predicted and chronologic age of participants (δage) would reflect accelerated ...

    • What factors explain the much higher diabetes prevalence in Russia compared with Norway? Major sex differences in the contribution of adiposity 

      Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Malyutina, Sofia; Kudryavtsev, Alexander V; Cook, Sarah; Wild, Sarah; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)
      <i>Introduction</i> - Compared with many other countries Russia has a high prevalence of diabetes in men and women. However, contrary to what is found in most other populations, the risk is greater among women than men. The reasons for this are unclear.<br><br> <i>Research design and methods</i> - Prevalence and risk factors for diabetes at ages 40–69 years were compared in two population-based ...

    • What should be the baseline when calculating excess mortality? New approaches suggest that we have underestimated the impact of the COVID-19 pandemic and previous winter peaks 

      Shkolnikov, Vladimir M.; Klimkin, Ilya; McKee, Martin; Jdanov, Dmitri A.; Alustiza-Galarza, Ainhoa; Németh, László; Timonin, Sergey A.; Nepomuceno, Marília R.; Andreev, Evgeny M.; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-18)
      Excess mortality has been used to measure the impact of COVID-19 over time and across countries. But what baseline should be chosen? We propose two novel approaches: an alternative retrospective baseline derived from the lowest weekly death rates achieved in previous years and a within-year baseline based on the average of the 13 lowest weekly death rates within the same year. These baselines express ...