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norskBlar i forfatter "Melsom, Toralf"
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Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)<p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ... -
Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study
(Master thesis; Mastergradsoppgave, 2019-10-28)Background: Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive function in ... -
Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ... -
Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-31)Hyperfiltration is a state of high glomerular filtration rate (GFR) observed in early diabetes that damages glomeruli, resulting in an iterative process of increasing filtration load on fewer and fewer remaining functional glomeruli. To delineate underlying cellular mechanisms of damage associated with hyperfiltration, transcriptional profiles of kidney biopsies from Pima Indians with type 2 ... -
N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ... -
Nitric Oxide Precursors and Dimethylarginines as Risk Markers for Accelerated Measured GFR Decline in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-19)Introduction: Nitric oxide (NO) deficiency is associated with endothelial dysfunction, hypertension, atherosclerosis, and chronic kidney disease (CKD). Reduced NO bioavailability is hypothesized to play a vital role in kidney function impairment and CKD. We investigated the association of serum levels of endogenous inhibitors of NO, asymmetric dimethylarginine (ADMA) and symmetric dimethylargin ... -
Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)Background - A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.<p> <p>Methods - Standardized creatinine and measured glomerular ... -
Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)<p><i>Aim:</i> The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. <p><i>Methods:</i> In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), ... -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29) -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an independent risk factor for glomerular hyperfiltration and high-normal ... -
Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-13)Background - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods ... -
Renal Functional Response-Association With Birth Weight and Kidney Volume
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)<b><p>Introduction:</b> Renal functional response (RFR) is the acute increase in glomerular filtration rate (GFR) after a protein load. Low RFR is a marker of single nephron hyperfiltration. Low birth weight (LBW) is associated with reduced number of nephrons, lower kidney function, and smaller kidneys in adults. In the present study, we investigate the associations among LBW, kidney volume, and ... -
Renal hyperfiltration, impaired fasting glucose and physical exercise in the general population : a cross-sectional study
(Doctoral thesis; Doktorgradsavhandling, 2012-06-12)Kronisk nyresykdom er vanlig og rammer ca 10 % av befolkningen. Forhøyet blodsukker og insulin ser ut til å gi nyreskade mens fysisk trening kan være beskyttende. Unormalt høy renseevne (filtrasjon) i nyrene, såkalt hyperfiltrasjon, er et fenomen som på sikt antas å gi proteinutskillelse i urinen og etter hvert nedsatt filtrasjon, det vil si kronisk nyresykdom. Hvilke faktorer som bidrar til ... -
Serum Matrix Metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with ... -
Sex Differences in Age-Related Loss of Kidney Function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)Background - CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood.<p> <p>Methods - We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by comorbidity or CKD risk factors. In the Renal Iohexol Clearance Survey (RENIS) in northern Europe, ... -
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-11)Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline ... -
Urinary excretion of epidermal growth factor and rapid loss of kidney function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-17)Background - Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.<p> <p>Methods ... -
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-07)<p><i>Introduction</i>: Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear.</p> <p><i>Methods</i>: We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and ... -
Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-02)Objectives. Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio ... -
Validation of eGFR for Detecting Associations Between Serum Protein Biomarkers and Subsequent GFR Decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08)Significance Statement - eGFR from creatinine, cystatin C, or both has been primarily used in search of biomarkers for GFR decline. Whether the relationships between biomarkers and eGFR decline are similar to associations with measured GFR (mGFR) decline has not been investigated. This study revealed that some biomarkers showed statistically significant different associations with eGFR decline ...
