Blar i forfatter "Nossent, Johannes C"

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    • Should Pneumocystis jiroveci prophylaxis be recommended with Rituximab treatment in ANCA-associated vasculitis? 

      Besada, Emilio; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Reports in haematology, transplantation medicine and rheumatology indicate that Rituximab, a B cell depleting therapy, increases the risk for Pneumocystis jiroveci pneumopathy. Patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis have an increased incidence of P. jiroveci pneumopathy compared to other autoimmune diseases and Rituximab is often used to induce and maintain ...

    • Should rheumatoid factor in rheumatoid arthritis be sent to Davy Jones's Locker? 

      Besada, Emilio; Nikolaisen, Cathrin; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      This article reviews the characteristics and weaknesses of the rheumatoid factor (RF) assay compared with anticitrullinated peptide antibody (ACPA) testing in the work-up of patients with synovitis. This should lead physicians to change their ordering habits and replace RF by ACPA. For RA diagnosis, good clinical judgement based on clinical history, physical examination and routine laboratory work ...

    • Susceptibility for Lupus Nephritis by low copy number of the FCGR3B gene is linked to increased levels of pathogenic autoantibodies 

      Nossent, Johannes C; Becker-Merok, Andrea; Rischmueller, Maureen; Lester, Sue (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (𝑛 = 107). FCGR3B CN was determined by three different qPCR parameter estimations (Ct−, Cy0, and cpD1) and confirmed by the FCGR2C/FCGR2A paralog ratio test. ...