The Neolithic and Bronze Age construction and habitation of the Stonehenge Landscape has been extensively explored in previous research. However, little is known about the scale of pre-Neolithic activity and the extent to which the later monumental complex occupied an ‘empty’ landscape. There has been a long-running debate as to whether the monumental archaeology of Stonehenge was created in an ...

Background The complement system plays an important role in pathophysiology of cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid arthritis (RA). The role of complement activation in response to treatment, and in development of premature CVD in RA, is limited. Therefore, we examined the effects of methotrexate (MTX) and tumor necrosis factor inhibitors ...

We describe an update of MirGeneDB, the manually curated microRNA gene database. Adhering to uniform and consistent criteria for microRNA annotation and nomenclature, we substantially expanded MirGeneDB with 30 additional species representing previously missing metazoan phyla such as sponges, jellyfish, rotifers and flatworms. MirGeneDB 2.1 now consists of 75 species spanning over ∼800 million ...

Background: Infammation has been hypothesized to play a role in the development and progression of breast can‑ cer and might diferently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 ...

Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.<p> <p>Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD ...

Shrimp aquaculture systems vary from primitive (extensive/ improved extensive) to more industrialized (intensive/semiintensive) farms, and the impacts of environmental shocks may differ between them. This article applies the Cobb– Douglas stochastic production frontier function to evaluate the determinants that impact the inefficiency of these intensive and extensive systems in Vietnam. Data ...

Patient self-management is vital to improved health outcomes for patients with chronic diseases. The objective of this study was to understand the role of wearable sensors in patients’ self-management. A survey encompassing factors related to motivation in mHealth was conducted. Ease of use and sensory accuracy was found most important when choosing a wearable. Manual registration of most health-related ...

Type 2 diabetes mellitus (T2D) and prediabetes prevalence rates are high. Consequences are serious, but current treatment is often not efficient for achieving remission. Remission may be achieved through lifestyle intervention. Frequent follow-up is necessary, and health care personnel (HCP) lack resources, time, and often adequate knowledge. Self-management of T2D can benefit from better use of ...

The COVID-19 pandemic has become a global health and humanitarian crisis that catastrophically affects many industries. To control the disease spread and restore normal lives, mass vaccination is considered the most effective way. However, the sustainable last-mile cold chain logistics operations of COVID-19 vaccines is a complex short-term planning problem that faces many practical challenges, ...

Cruise no.: 2022703 : The 2022 survey of harp and hooded seal pup production in the Greenland Sea was carried out to obtain updated estimates to be used to assess current status of these two seal stocks. Since a similar survey in 2018 indicated a 40% reduction in harp seal pup production since the 2012 survey, and the continued lack of increase in pup production of the severely depleted hooded ...