We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosomedamaging agents including SARS-CoV-2ORF3a, Mycobacterium tuberculosis, and proteopathic tau. During damage, mammalian ATG8s directly interacted with the ...

Social role theory posits that binary gender gaps in agency and communion should be larger in less egalitarian countries, reflecting these countries’ more pronounced sex-based power divisions. Conversely, evolutionary and self-construal theorists suggest that gender gaps in agency and communion should be larger in more egalitarian countries, reflecting the greater autonomy support and flexible ...

In this in­depth single­case study from a large international aerospace and defence company, we ask the following research question: In what ways does lean production influence organizational resilience? Our findings suggest that various lean practices, such as lean meetings, using lean tools and a lean production­inspired organizational culture promote the development of organizational capabilities ...

This report builds the knowledge base for the transnational educational project ‘Voices of Women’ (https://voicesofwomen.eu) funded by the European Union. The report situates the VOW project within music and gender research in Norway, The Netherlands, and Germany. It argues for the need to educate agents of change and outlines the VOW approach along four pillars: (1) Performative Research (2) Unheard ...

Høyt fravær fra skolen er en stor utfordring. Eleven går glipp av mye opplæring, og det kan føre til at eleven ikke får standpunktkarakter. Høyt fravær en også en risikofaktor for frafall på videregående skole. I Norge faller en av fire elever fra videregående opplæring. Ulike tiltak vil kunne hjelpe eleven møte på skolen og fullføre opplæringen.<p> <p>Vi undersøkte hvilke sekundær- og ...

The CAGE22-6 cruise on-board R/V Helmer Hanssen hosted UiT´s Arctic Marine Geology and Geophysics (GEO-8144 and GEO-3144) field course for PhD and Master students, and was carried out in collaboration with NPD – the Norwegian Petroleum Directorate and the INTPART project HOTMUD based at Centre for Earth Evolution and Dynamics (CEED) the University of Oslo. The cruise was also a part of the UNESCO ...

On the mid-Norwegian margin, extensive rifting and subsequent deposition of thick Cretaceous and Cenozoic sediments have buried the traditional Upper Jurassic organic-rich shales too deep. Consequently, these organic-rich shales are overmature and spent in the deep basins on the mid-Norwegian margin. The absence of well-control, variable seismic quality and in particularly, the great burial depth, ...

Este artículo discute una de las clases reconocidas de prefijos en español, los prefijos adjetivales. Esta clase muestra propiedades que no encajan con el resto de los prefijos, tanto en su fonología como en su semántica. Se argumenta que la clase es heterogénea y deben distinguirse en ella al menos cuatro subtipos de elementos. Sus propiedades excepcionales, junto a su ordenamiento lineal y su ...

As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption using in vitro dissolution remains difficult. The objective of this study was to obtain insight into ...